Braunodin B. Brown - instructions for use, indications, doses

Release form and composition

Dosage forms:

solution for external and local use 7.5%: a transparent brown liquid with a characteristic odor of iodine (in a polyethylene bottle: 30 ml, in a cardboard box 1 bottle complete with a dropper nozzle; 250 ml in a bottle with a mechanical spray and with a cap for it, in a cardboard box 1 bottle; 100 ml, in a cardboard box 1 bottle; for hospitals: 100 ml, 250 ml or 500 ml, in a cardboard box 20 bottles; 1000 ml in a polyethylene bottle, in a cardboard box 10 bottles; 5000 ml in a polyethylene canister);
ointment for external use 10%: brown mass with a characteristic odor of iodine (20 g, 100 g and 250 g each in a laminated tube, 1 tube in a cardboard box; for hospitals - 250 g in a polypropylene jar, 6 cans in a cardboard box ).

100 g of solution contains:

active ingredient: povidone-iodine (containing active iodine 10%) – 7.5 g;
auxiliary components: sodium iodate, lauromacrogol-400, sodium hydroxide, sodium dihydrogen phosphate dihydrate, purified water.

100 g of ointment contains:

active ingredient: povidone-iodine (containing active iodine 10%) – 10 g;
auxiliary components: macrogol-400, sodium bicarbonate, macrogol-4000, purified water.

Indications for use

post-traumatic and postoperative wounds of various locations, trophic ulcers, burns, bedsores;
skin infections of various origins, including dermatitis and eczema of an infectious nature;
damage to the skin of various origins, abrasions, maceration, bruises.

In addition, the use of the solution is indicated:

diabetic foot;
infections of the nasopharynx and oral cavity;
treatment of the skin and mucous membranes around drainages, probes and catheters, in preparation for and after surgery, biopsy or puncture;
hygienic treatment of the hands of surgeons and medical personnel;
gynecological operations for artificial termination of pregnancy, insertion of an intrauterine device, coagulation of polyp and erosion;
infections of the birth canal mucosa in women.

Braunodin B. Brown 7.5% 100 ml No. 1 bottle

Content

Pharmacodynamics Indications Contraindications Use with caution Use during pregnancy and lactation Method of administration and dosage Side effects Overdose Interaction Special instructions Storage conditions Expiration date

Pharmacodynamics

An antiseptic agent, which is a complex of iodine and povidone, effective at pH from 2 to 7. The bactericidal effect is due to free active iodine, which is released from the povidone-iodine complex. Compared to alcohol-containing iodine solutions, an aqueous solution of povidone-iodine has a significantly less irritating effect.

Free iodine, as a strong oxidizing agent, reacts at the molecular level with insoluble fatty acids and practically non-oxidizable SH- and OH-groups of amino acids in the enzymes and main structural components of bacteria, both gram-positive and gram-negative, mycobacteria, fungi, especially the genus Candida (Candida), various viruses and some protozoa. However, for complete inactivation of some viruses and bacterial spores, a sufficiently long period of exposure to the drug is required.

There are no known cases of the development of resistance in microorganisms with long-term use of povidone-iodine.

Indications

Post-traumatic and postoperative wounds of various locations, burns, trophic ulcers, bedsores, diabetic foot.
Damage to the skin of various origins, maceration, abrasions, bruises.
Skin infections of various etiologies, including infectious dermatitis and eczema.
Treatment of the patient's mucous membranes and skin before and after surgery, biopsy, puncture, including the skin around drainages, catheters and probes.
Hygienic treatment of the hands of medical personnel, treatment of the hands of surgeons.
Infections of the oral mucosa and nasopharynx.
Infections of the mucous membrane of the birth canal in women. Carrying out “minor” gynecological operations (artificial termination of pregnancy, insertion of an intrauterine device, coagulation of erosion and polyp).

Contraindications

Hypersensitivity to the components of the drug.
Thyroid dysfunction (thyrotoxicosis).
Thyroid adenoma.
Dühring's dermatitis herpetiformis.
Simultaneous use of radioactive iodine.
Premature babies, newborns and children up to 6 months.

Carefully

Chronic renal failure.

Use during pregnancy and breastfeeding

The drug is not recommended for use from the third month of pregnancy and during breastfeeding.

It is possible to use the solution in pregnant women until the ninth week of pregnancy, when the expected benefit from treatment with the drug exceeds the possible risk of complications.

Directions for use and doses

Externally, locally.

The drug is used in the form of a 7.5% solution or diluted. To dilute the drug, 0.9% sodium chloride solution, Ringer's solution, or phosphate buffer solution can be used.

Povidone-Iodine is applied to the surface by lubrication using a swab soaked in the solution, irrigation using a mechanical sprayer, and also leaving napkins soaked in the solution on the surface.

The drug in the form of a 7.5% solution is used for the antiseptic treatment of shallow wounds, burns, skin damage: abrasions, bruises; for treating the patient’s skin and mucous membranes before and after surgery, biopsy or puncture, skin around drains, catheters and probes.

When treating the skin before surgery, it is necessary to use a solution, avoiding its “accumulation” under the patient, as this can cause skin irritation.

To treat the hands of surgical personnel, 5 ml of the drug in the form of a 7.5% solution is applied to the skin of the hands and treated for 2.5 minutes. The procedure is repeated twice. For hygienic treatment of hands, apply 3 ml to the skin and treat them for 1 minute. Then rinse thoroughly with water.

The drug in diluted form is used:

in a dilution of 1:2–1:20 for washing deep wounds, bedsores, trophic ulcers, during intraoperative treatment of wounds;
in a dilution of 1:25 during preoperative preparation of patients: washing the limbs;
in a dilution of 1:100 during preoperative preparation of patients: body wash;
in the form of a 1% solution when diluted with a phosphate buffer solution: applied to the mucous membrane of the eyes.

All solutions of the drug are used only freshly prepared.

Povidone-iodine solutions should be applied to the damaged surface until it is completely moistened.

Apply napkins soaked in povidone-iodine solution to the wound sutures. The antiseptic film formed when povidone-iodine dries is easily washed off with water.

Povidone-iodine solutions should be continued until signs of infection have resolved or until there is no obvious risk of infection.

Povidone-iodine solutions are non-irritating and do not slow down wound healing even with long-term use.

Side effects

Hypersensitivity reactions to the drug are possible: delayed allergic reactions (itching, redness of the skin, blisters) or immediate allergic reactions (anaphylactoid reactions).

Long-term use of the drug (more than 7-10 days) and application to large surfaces of the skin, extensive wounds due to absorption can cause symptoms of iodism (“metallic” taste in the mouth, increased salivation and lacrimation, swelling of the mucous membranes) and systemic reactions (metabolic acidosis, hyponatremia , impaired renal and thyroid function), if they occur, you should stop using the drug and consult a doctor.

Overdose

After extremely intense iodine absorption over a prolonged period, symptoms of hyperthyroidism may be noted, such as tachycardia, restlessness, tremors and headache. Mild forms of hyperthyroidism sometimes do not require intervention, but severe forms may require thyrostatic therapy.

Interaction

The drug is incompatible with alkaloid salts (celandine), tannic acid (tannin), salicylic acid, silver salts, bismuth, taurolidine and hydrogen peroxide.

In the presence of blood and pus, the drug binds to proteins and other organic compounds, as a result of which its bactericidal activity may decrease. In this case, it is recommended to increase the frequency/frequency of use of the drug.

The simultaneous use of povidone-iodine and topical preparations containing enzymes may promote oxidation and suppress their enzymatic activity.

Povidone-iodine has a synergistic effect with lithium preparations, as a result of which, with their long-term combined use, reversible depression of thyroid function is possible. Therefore, patients chronically taking lithium should avoid prolonged application of povidone-iodine to large surfaces.

The drug may lead to false-positive results in some diagnostic tests: determination of hemoglobin or sugar in urine and stool, testing of thyroid function. In this case, examination of the thyroid gland should be carried out no earlier than 1–2 weeks after the end of povidone-iodine treatment.

special instructions

Avoid contact of undiluted drug with eyes.

Storage conditions

Store at a temperature not exceeding 25 °C in a place protected from light.

Keep out of the reach of children.

Best before date

3 years in 30 ml, 100 ml and 250 ml bottles
5 years in bottles of 500 and 1000 ml, in a canister of 5 liters.

Do not use after the expiration date stated on the package.

Contraindications

thyrotoxicosis (functional disorder of the thyroid gland);
simultaneous intake of radioactive iodine;
Dühring's dermatitis herpetiformis;
thyroid adenoma;
the period from the third month of pregnancy and the period of breastfeeding;
prematurity (in newborns);
age up to 6 months;
hypersensitivity to the components of the drug.

It is recommended to use Braunodin B. Brown with caution in chronic renal failure and up to the third month of pregnancy.

Pharmacological properties

Pharmacodynamics

Braunodin B. Brown is an antiseptic, which is a complex of iodine and povidone. Effective at pH values from 2 to 7.

The bactericidal effect of the drug is due to free active iodine released from the povidone-iodine complex.

As a strong oxidizing agent, free iodine interacts at the molecular level with insoluble fatty acids and practically non-oxidizable OH- and SH-groups of amino acids contained in enzymes and the main structural components of gram-positive and gram-negative bacteria, fungi (especially the genus Candida), mycobacteria, some protozoa and various viruses. Only for complete inactivation of some bacterial spores and viruses is a long period of exposure to povidone-iodine required.

In the form of a solution, Braunodin B. Brown has a significantly less irritating effect compared to other solutions containing alcohol.

There have been no cases of the development of resistance in microorganisms even with long-term use of the drug.

Pharmacokinetics

After external use of Braunodin B. Brown, some absorption of iodine is possible, so it is important to consider the location of application of the drug, its amount and duration of treatment.

If the product is applied in small quantities to intact skin, iodine absorption is negligible.

Increased absorption is possible with long-term use of povidone-iodine on mucous membranes, large wounds, burns, and also when washing cavities. Because of this, there is a temporary increase in the concentration of iodine in the blood. In people with a healthy thyroid gland, high iodine levels do not lead to clinical changes in the condition of the thyroid gland. In patients with normal metabolic processes, excess iodine is excreted through the kidneys.

Directions for use and dosage

Solution for external and local use

The drug is used externally or locally (including in diluted form) by lubricating the surface of the body with a swab soaked in the solution, or irrigating with a mechanical sprayer, or applying napkins soaked in the solution to the affected areas of the body. The solution should be applied liberally to the damaged surface until it is completely moistened.

For antiseptic treatment of hands before surgery, medical staff apply 5 ml of a 7.5% solution to the skin of the hands and wipe them for 2.5 minutes. The procedure is carried out twice. For hygienic treatment, use 3 ml of solution for 1 minute. After wiping, rinse hands thoroughly with water.

For antiseptic treatment of skin injuries (abrasions, bruises), burns, shallow wounds, skin areas adjacent to drainages, catheters and probes, mucous membranes and skin before and after surgery, during puncture or biopsy, the solution is used in its pure form.

For dilution, you can use Ringer's solution, 0.9% sodium chloride solution, phosphate buffer solution.

Recommended proportions for diluting the drug:

washing of deep wounds, bedsores, trophic ulcers, intraoperative treatment of wounds: from 1:2 to 1:20;
preoperative preparation of patients - washing extremities: 1:25;
preoperative preparation of patients - body washing: 1:100.

For application to the mucous membrane of the eyes, the drug is diluted with a phosphate buffer solution to 1% solution concentration.

Only freshly prepared solutions should be used.

Povidone-iodine solution can be used for a long time, until the signs of infection completely disappear or there is an obvious risk of developing signs of infection, since it does not irritate wounds and does not slow down their healing period.

Ointment for external use

Braunodin B. Brown in the form of an ointment is intended for external use by application to affected areas of the body, including the use of gauze swabs, bandages and turundas.

Recommended dosage regimen: 1–3 times a day, the course is continued until the symptoms of inflammation completely disappear, usually 5–10 days.

Brownodin B. Brown

The ointment is used externally, applied to the affected surface from one to several times a day until the symptoms of inflammation disappear. If necessary, use bandages, gauze swabs and turundas.

The frequency and duration of use of the ointment depends on the course of the wound process. The course of treatment is 5-10 days.

The solution is used externally, topically, in the form of a 7.5% solution or diluted. To dilute the drug, 0.9% sodium chloride solution, Ringer's solution, or phosphate buffer solution can be used.

Povidone-iodine is applied to the surface by lubrication using a swab soaked in the solution, irrigation using a mechanical sprayer, and also leaving wipes soaked in the solution on the surface.

When treating the skin before surgery, it is necessary to use a solution, avoiding its “accumulation” under the patient, as this can cause skin irritation.

The drug in diluted form is used:

- in a dilution of 1:2 - 1:20 for washing deep wounds, bedsores, trophic ulcers, during intraoperative treatment of wounds;

— at a dilution of 1:25 during preoperative preparation of patients: washing the limbs;

— at a dilution of 1:100 during preoperative preparation of patients: body wash;

— in the form of a 1% solution when diluted with a phosphate buffer solution: applied to the mucous membrane of the eyes.

All solutions of the drug are used only freshly prepared.

Povidone-iodine solutions should be applied to the damaged surface until it is completely moistened.

Apply napkins soaked in povidone-iodine solution to the wound sutures. The antiseptic film formed when povidone-iodine dries is easily washed off with water.

Povidone-iodine solutions should be continued until signs of infection have resolved or until there is no obvious risk of infection.

Povidone-iodine solutions are non-irritating and do not slow down wound healing even with long-term use.

Side effects

hypersensitivity reactions: possible - allergic reactions of both delayed type in the form of itching, redness of the skin, blisters, and immediate type in the form of anaphylactoid reactions;
other: possible [against the background of long-term (more than 7 days) use and/or application to large areas of the skin] – phenomena of iodism (swelling of the mucous membranes, metallic taste, increased lacrimation and salivation), systemic reactions (hyponatremia, metabolic acidosis, functional kidney disorder, thyroid dysfunction).

special instructions

Do not allow undiluted solution or ointment to get into your eyes.

If symptoms of systemic disorders appear, use of the drug should be stopped and consult a doctor.

When using the solution to prepare a patient for surgery, you must make sure that after application the solution does not flow under the patient’s body, since its accumulation can cause skin irritation.

After the solution dries, an antiseptic film is formed, which is easily washed off with water.

Drug interactions

Braunodin B. Brown cannot be combined with tannic acid (tannin), alkaloid salts (celandine), bismuth and silver, salicylic acid, hydrogen peroxide, taurolidine.

It is recommended to increase the frequency of use of the drug when treating purulent or bleeding surfaces, since povidone-iodine binds to organic compounds (including protein) and reduces its bactericidal activity.

Povidone iodine may cause oxidation and inhibit the enzymatic activity of other topical medications containing enzymes.

Long-term combined use with lithium preparations promotes the development of reversible inhibition of thyroid function, since this combination has a synergistic effect. Patients on continuous therapy with lithium are recommended to limit the period of use of the drug on large areas of the body.

Since povidone-iodine can lead to false-positive results in diagnostic tests of thyroid function, analysis to determine the sugar and hemoglobin content in urine or stool, examination of the thyroid gland should be carried out after the end of treatment with the drug no earlier than 1-2 weeks.

Braunodin B Brown ointment for external use 10% 20g

Compound

Active substance: povidone-iodine - 10 g. Excipients: macrogol-400, macrogol-4000, sodium bicarbonate, purified water up to 100 g.

Pharmacokinetics

After applying the ointment, some absorption of iodine is possible, which must be taken into account depending on the location, amount and duration of use of the drug.

If small amounts of the drug are applied to intact skin, then iodine resorption is insignificant. High absorption rates may result from long-term use of drugs containing povidone-iodine on large wounds and burns. As a result, there is a temporary increase in iodine content in the blood. In people with a healthy thyroid gland, higher iodine levels do not cause clinically significant changes in thyroid health. During normal iodine metabolism, excess iodine is removed through the kidneys.

Indications for use

Post-traumatic and postoperative wounds of various locations, burns, trophic ulcers, bedsores.
Skin infections of various etiologies, including infectious dermatitis and eczema.
Damage to the skin of various origins (maceration, abrasions, bruises).

Contraindications

Hypersensitivity to the components of the drug.
Thyroid dysfunction (thyrotoxicosis).
Thyroid adenoma.
Dühring's dermatitis herpetiformis.
Simultaneous use of radioactive iodine.
Premature babies, newborns and children up to 6 months.

With caution: Chronic renal failure, pregnancy, breastfeeding.

Directions for use and doses

Externally.

The drug is applied to the affected areas of the skin in a thin layer 2-3 times a day. The frequency of application and duration of use of the drug depend on the location and severity of skin lesions.

The course of treatment is usually 5-10 days.

If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.

Use the drug only according to the indications, the method of use and in the doses indicated in the instructions for use.

Storage conditions

Store at temperatures from 2 °C to 25 °C, protected from light.

Keep out of the reach of children.

Best before date

5 years. Do not use after the expiration date stated on the package.

special instructions

In case of dysfunction of the thyroid gland, the use of the drug is possible only under the strict supervision of a doctor.
Caution should be exercised when used regularly on damaged skin in patients with chronic renal failure.
A colored film is formed at the site of application, which persists until the entire amount of active iodine is released, which means the cessation of the action of the active substance.
Coloring on leather and fabrics is easily washed off with water.
Do not use for bites from insects, domestic or wild animals.

Description

Antiseptic for external use.

Dosage form

The ointment is brown in color with a characteristic odor of iodine.

Use in children

Contraindication: premature and newborn babies.

Pharmacodynamics

Antiseptic and disinfectant. Released from the complex with polyvinylpyrrolidone upon contact with the skin and mucous membranes, iodine forms iodamines with bacterial cell proteins, coagulates them and causes the death of microorganisms. It has a rapid bactericidal effect on gram-positive and gram-negative bacteria (with the exception of Mycobacterium tuberculosis). Effective against fungi, viruses, protozoa.

Side effects

When using the drug, undesirable reactions are possible: hyperemia, burning, itching, swelling, pain.

In rare cases, povidone iodine can cause hypersensitivity reactions, such as contact dermatitis with the formation of psoriasis-like red small bullous lesions. If such phenomena occur, use of the drug should be discontinued.

Very rarely, anaphylactoid reactions up to anaphylactic shock are possible.

Long-term use, application to large areas of skin, and the use of occlusive dressings can lead to the absorption of significant amounts of iodine. In some cases, the development of iodine-induced hyperthyroidism has been described, mainly in patients with pre-existing thyroid disease.

If you experience the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Use during pregnancy and breastfeeding

The drug is not recommended for use from the third month of pregnancy and during breastfeeding.

The use of the drug during these periods is possible if the expected benefit to the mother outweighs the possible risk to the fetus and child.

If it is necessary to use the drug in these cases, treatment is possible under medical supervision.

Before using Braunodin B. Brown, if you are pregnant, or think you might be pregnant, or are planning a pregnancy, you should consult your doctor.

Interaction

The drug is incompatible with alkaloid salts (celandine), tannic acid (tannin), salicylic acid, silver salts, bismuth, taurolidine and hydrogen peroxide.

The simultaneous use of povidone-iodine and topical preparations containing enzymes may promote oxidation and suppress their enzymatic activity.

If you are using the above or other medications (including over-the-counter medications), consult your doctor before using Braunodin B. Brown.

Overdose

Acute iodine intoxication is characterized by the following symptoms: metallic taste in the mouth, increased salivation, burning sensation or pain in the mouth or throat; irritation and swelling of the eyes; skin reactions; gastrointestinal disorders; renal dysfunction and anuria; circulatory failure; laryngeal edema with secondary asphyxia, pulmonary edema, metabolic acidosis, hypernatremia.

Treatment: Symptomatic and supportive therapy should be carried out with special attention to electrolyte balance, renal and thyroid function.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.