List of cheap analogues of Derinat, instructions and comparison of their effectiveness

Among the wide range of drugs that can stimulate immune defense, Derinat is popular, which is available in several forms - spray, nasal drops, solution for local and external use, as well as ampoules for intramuscular injections.

The drug is produced by the Russian pharmaceutical company. Despite the fact that Derinat is a domestic medicine, its price exceeds 340 - 1900 rubles (depending on the form of release).

Due to the fact that the drug is quite expensive, many are looking for cheaper substitutes. Before considering analogues to replace Derinat, it is worth familiarizing yourself with the drug itself, its properties, indications, dosages and contraindications.

pharmachologic effect

Derinat is not an antibiotic, but a drug with a pronounced immunomodulatory effect, which is used in various fields of medicine for the treatment and prevention of a wide variety of diseases.

Thanks to the active component - sodium deoxyribonucleate, which is obtained from the milt of sturgeon fish, the medicine has a pronounced drainage-detoxification, anti-inflammatory property. Its mechanism of action is aimed at stimulating the functioning of the immune system, as well as restoring the mucous membranes and skin.

The immunomodulatory effect of the drug allows you to increase the production of immunoglobulins, thereby fighting viruses, bacteria and fungi.

When Derinat is applied externally in the form of a solution, it is possible to accelerate the healing of wounds in the presence of trophic ulcers, burns, cuts, and frostbite. In addition, the drug has the ability to restore damaged tissue of the oral mucosa during sore throat, tonsillitis, and stomatitis without scarring.

Derinat in the form of spray and drops is more often used in the treatment of ENT diseases, also for acute respiratory viral infections and influenza.

With prolonged use of the drug, deoxyribonucleate accumulates in the lymph nodes and bone marrow tissues. This allows for a constant concentration of the active substance in the body.

The maximum concentration of the component in the blood plasma is observed 5 hours after use. The medicine is excreted by the kidneys and intestines (with feces).

Derinat drops 0.25% 10ml (PharmPak)

Derinat - stimulating hematopoiesis, regenerating, reparative, wound healing, immunomodulatory. Pharmacodynamics The drug has a modulating effect on the cellular and humoral components of the immune system and nonspecific resistance of the body, which leads to optimization of the inflammatory reaction and specific immune response to bacterial, viral and fungal antigens. The immunomodulatory effect of Derinat® is due to its ability to stimulate B-lymphocytes, activate T-helper cells and cells of the monocyte-macrophage system. The drug accelerates energy metabolism inside the cell, RNA and DNA synthesis. Activation of cellular immunity by Derinat® increases the ability of natural killer cells to act on cells affected by viruses, chlamydia, Staphylococcus aureus, Escherichia coli, Helicobacter, etc. Derinat® stimulates reparative and regenerative processes. The drug has anti-inflammatory, antitumor, antiallergic and detoxifying effects, as well as antioxidant and membrane-stabilizing properties. Derinat® normalizes the condition of the body in dystrophies of vascular origin, has a weak anticoagulant effect. Derinat® helps remove free radicals from the body, reduces the sensitivity of cells to the damaging effects of chemotherapy drugs. In the body, the drug accumulates mainly in the organs of the immune system and hematopoiesis - the bone marrow , spleen, lymph nodes, as well as in the intestinal epithelium. Increases the body's resistance to infections. Stimulates hematopoiesis (normalizing the number of leukocytes, lymphocytes, granulocytes, phagocytes, platelets). Having pronounced lymphotropism, Derinat® stimulates the drainage and detoxification function of the lymphatic system. Derinat® significantly reduces the sensitivity of cells to the damaging effects of chemotherapy drugs and radiation therapy. It has cardioprotective, anti-ischemic and cytoprotective effects. When Derinat® is included in the complex therapy of patients with coronary artery disease, the contractile function of the myocardium is improved, the death of cardiomyocytes is prevented, and tolerance to physical activity increases. For gastric and duodenal ulcers, the drug has a reparative effect, restoration of the mucous membrane and a pronounced immunomodulatory effect aimed at eliminating the infectious factor Helicobacter pylori. The drug does not have embryotoxic, teratogenic or carcinogenic effects.

Indications for use

The instructions for use state that Derinat can be used in monotherapy:

• for the treatment and prevention of acute respiratory viral infections and acute respiratory infections
• for inflammatory and dystrophic lesions of the organs of vision;
• For inflammatory diseases of the oral cavity.

In combination with other drugs to enhance their effect, Derinat is prescribed in the following cases:

• acute and chronic diseases of the upper respiratory tract (rhinitis, sinusitis, sinusitis);
• chronic inflammation of the mucous membrane in gynecology (of various origins); damage to the skin (burns, ulcers, frostbite, gangrene, post-radiation necrosis of tissues and mucous membranes);
• obliterating diseases of the lower extremities;
• infectious inflammatory processes of the pulmonary profile (bronchitis, pneumonia, tuberculosis).

In practice, spray or drops are prescribed for the treatment or prevention of acute viral infections of the ENT organs.

The solution is used for rinsing for diseases of the oral cavity - stomatitis, tonsillitis, pharyngitis and in surgery - to accelerate the healing of the skin.

In ophthalmology, sterile Derinat eye drops are used for inflammatory eye lesions.

The injection solution is prescribed to stimulate the immune response, both in case of bacterial and viral lesions of the body.

Inhalations with Derinat are carried out for any infectious and inflammatory blockages of the upper and lower respiratory tract with the same injection solution, using a nebulizer.

Dosages

The undeniable advantage of the medicine is that it can be used by children from birth, as well as by pregnant women (with caution). For effective treatment, it is important to correctly calculate the dosage and duration of therapy.

If there are no doctor’s prescriptions, you can stick to standard doses:

• To prevent ENT diseases, it is recommended to administer 2 drops into each nasal passage for children twice a day and 3 drops for adults.
• At the first signs of a cold, prescribe 2–3 drops every 2 hours on the first day and 3 drops three times a day for the next 7–20 days.
• If diseases of the nasal cavity are diagnosed, a single use of the drug is 4 - 5 drops 4 times a day. The total duration of treatment is up to 2 weeks.

Doses used in complex therapy of internal diseases are prescribed by a doctor taking into account the diagnosis, age, and characteristics of the body.

Contraindications and side effects

Derinat is from the group of immunostimulants, one of the few drugs that have no contraindications for use. The only restriction to use is considered to be individual intolerance to sodium deoxyribonucleate.

Adverse reactions after using the medicine have not been recorded in practice, but still the manufacturer reports that if you are hypersensitive to the composition, itching in the nose may occur.

When treating patients with diabetes mellitus, a hypoglycemic effect may develop, so it is necessary to monitor blood sugar levels. When administered by injection, body temperature may rise briefly.

Structural analogues of Derinat

• Deoxynate (0.25% solution in glass ampoules of 5 ml) from 1400 rub. for 50 ml. Used for intramuscular injections, rinsing the mouth, and external application for damaged skin. In general, this is the same Derinat, only in a different form of release (less convenient). To instill it into the nose, you will need to use a pipette, and to use it as a spray, you will need an empty bottle with a spray bottle, for example, one containing vasoconstrictor drops. If you compare prices, Deoxynate costs 280 rubles. for 10 ml. This is half the price of Derinat for injection. If you use the same solution for instillation into the nose, inhalation and rinsing, the benefit is almost imperceptible;
• Sodium Deoxyribonucleate (in powder form for self-preparation of solution) 250, 400 and 1000 grams.

The last option is relevant for medical institutions where large amounts of the drug are used.

For an ordinary patient, this is impractical and inconvenient, due to the need to maintain proportions and the inability to use all the medicine (the expiration date will expire before it runs out).

Derinat or Protargol

Manufacturer: ALVILS (Russia)
Release form: powder for preparing a solution for topical use

Active ingredient: silver proteinate

Protargol is an antiseptic that has an anti-inflammatory and astringent effect. The drug is indicated as symptomatic therapy for acute rhinitis, sinusitis, and nasopharyngitis. The use of Derinat for children will be preferable, since there are no age restrictions for the drug and the medication actively stops the manifestations of a viral infection, stimulating an increase in immunity in the child.

Which analogue of Derinat to give preference will be decided only by the doctor, taking into account the type of infection, the time of onset of the first symptoms and the age of the patient.

A large selection of Derinat analogues allows the doctor to select the appropriate medication that will stop the manifestations of the disease in the shortest possible time and increase the body’s defenses.

List of analogues by therapeutic effect

The list of drugs that can be used as substitutes for Derinat in case of viral etiology of the disease is as follows:

• Kagocel (tablets) – from 260 rubles;
• Arbidol (tablets) – from 230 rubles;
• Ingavirin 90 mg (capsules) – 510 rubles;
• Grippferon nasal drops 10,000 IU/ml, 10 ml – 270 rubles;
• Nazoferon spray – from 280 rubles;
• IRS-19 nasal spray 20 ml – 500 rub.;
• Poludan nasal drops 100 units, bottle 1 pc. – 630 rubles.

Some analogues of Derinat are available in other forms and with a different composition, but have a similar immunomodulating effect.

To achieve maximum results, all of them must be taken at the initial symptoms of the disease (preferably in the first or second day). On the 4-5th day, a positive result will be only as part of complex treatment with systemic and other symptomatic agents.

List of inexpensive substitutes for children

Drugs from the group of immunomodulators and immunostimulants are especially popular in pediatrics. They are prescribed not only for therapeutic, but also for preventive purposes.

To replace Derinat, children can use the following products from domestic and foreign pharmaceutical companies:

• Broncho-Munal 3.5 mg (capsules containing OM85 bacterial lysate) - prescribed for frequent respiratory diseases and ENT pathologies. The properties of the drug can be compared to a vaccine. It is well tolerated, increases immune defense, and rarely causes contraindications. Prescribed for children from 3 years of age. The price of the medicine is from 450 rubles.
• Grippferon is an inexpensive analogue of Derinat in the form of a nasal spray and nasal drops. It has an immunostimulating effect, has a detrimental effect on viruses, eliminates inflammation, and can be used for therapeutic and preventive purposes from birth. The cost of the medicine is from 270 rubles per bottle.
• IRS 19 is an analogue of Derinat for children from 3 months, which contains bacterial lysates. Available in the form of a nasal spray. It is used for various diseases of infectious origin of the ENT organs and respiratory system. A doctor must prescribe the medicine, since the drug has a number of contraindications and side effects. Price is about 470 rubles per 20 ml bottle. (60 doses).
• Nazoferon is a cheaper analogue of Derinat spray. Refers to immunostimulating drugs based on recombinant human interferon alpha-2b. It has anti-inflammatory, antiviral and immunomodulatory activity. Used for acute respiratory viral infections, acute respiratory infections, and chronic diseases of the upper respiratory tract. Can be used from birth. The price of the drug is about 300 rubles.

Derinat - instructions for use

According to the instructions for use, Derinat is prescribed:

• for the initial manifestations of ARVI - 2-3 drops in each nasal passage 5-6 times a day, followed by a reduction in the frequency of use to 3-4 times a day for a duration of 5 days to a month;
• for inflammatory processes in the paranasal sinuses and nasal cavity - 3-5 drops in each stroke up to 6 times a day. The course of treatment is from 1 to 2 weeks;
• for dental diseases - rinse the mouth up to 6 times a day for up to 1.5 weeks (1 bottle for 2-3 times);
• in gynecological practice - insertion of tampons with medication or vaginal irrigation of 5 ml per procedure 1-2 times a day for a course of up to 10 days;
• in ophthalmic practice - 1-2 drops up to 3 times a day for a course of from 2 weeks to 1.5 months;
• for skin defects - applications with the drug on the wound surface 3-4 times a day or spraying 10-40 ml of the product on the site of inflammation up to 5 times a day. The course of treatment is up to 3 months.

Derinat has high activity and is well tolerated by patients. It has minimal contraindications and positive results of therapy.

Derinat spray or drops – which is better?

Both forms of Derinat are available in bottles with different attachments. The spray is equipped with a spray dispensing device, which is convenient for use by adults and children from 3 years of age. A nozzle made in the form of a dropper helps to bury Derinat into the nose.

For children, it is preferable to use Derinat drops in treatment. For infants under 1 year of age, the medicine can be dripped directly into the mouth or under the tongue. It is more convenient for adult patients to use Derinat spray, since it is sprayed into the nasal passages in measured doses. It is convenient to use it not only at home, but also outside the home if viral infection is being prevented.

Despite the effectiveness of the treatment result with the drug and its safety, the medication cannot be recommended for all patients due to intolerance to individual components. In this case, Derinat substitutes are prescribed, which are produced by manufacturers under the guise of:

• generics;
• combined agents having an identical mechanism of action;
• synonyms.

How can I replace Derinat if the patient has an allergic reaction to the drug?

The pharmacy chain has a sufficient number of analogues that are not inferior in effectiveness to this drug.

Table of analogues of Derinat with prices and country of origin

A large selection of analogues of Derinat nasal drops allows the doctor to make a choice of drug based on the individual characteristics of each patient’s body, the type and degree of activity of the pathological process.

Analogs of Derinat nasal drops can be supplemented with a number of drugs that have an immunomodulatory and anti-inflammatory effect on a number of diseases:

• Isofra;
• Interferon;
• Galavit;
• Cytovir;
• Taktivin;
• Ergoferon;
• Polydex;
• Anaferon;
• Arbidol;
• Nazivin;
• Nasobek;
• Ingavirin;
• Inferon.

The pharmaceutical industry produces a wide range of drugs in various price categories. You can choose analogues of Derinat for adults and children that are cheaper than imported ones, but give the same therapeutic effect.

Viferon

Manufacturer: FERON (Russia)
Release form: gel, ointment for external use, suppositories

Active ingredient: interferon alpha 2 b

The analog Derinat has immunostimulating and antiviral effects. Viferon actively suppresses the replication of viral DNA, that is, the doubling of the DNA molecule. The drug helps increase local immunity by stimulating the production of antibodies.

The analogue Derinat is used for the prevention and treatment of:

• ARVI;
• acute respiratory infections;
• flu;
• herpetic lesions of the skin and mucous membranes;
• upper respiratory tract diseases.

The drug has a prolonged effect. Gel, in a volume of 50 mm strips, is applied to each nasal passage or to the tonsils 2 times a day. The frequency of use of the analogue can be increased depending on the degree of disease activity.

Nasonex

Manufacturer: SCHERING-PLOUGH (Belgium)
Release form: nasal spray

Active ingredient: mometasone

Nasonex gives positive results in the treatment of a number of diseases as an antiallergic and anti-inflammatory agent. This analogue of Derinat for children can be used in the treatment of rhinitis of allergic origin from 2 years of age. And as an additional medication - in the treatment of sinusitis and rhinosinusitis with antibiotics from the age of 12.

The dosage of the Derinat analogue is 2 inhalations (50 mcg each) once a day in both nasal passages. According to indications, it can be increased to 4 inhalations per day. Children's analogue of Derinat is prescribed 1 inhalation 1 time per day. Clinical manifestations of the drug’s action are observed within 12 hours after its use.

Miramistin

Manufacturer: INFAMED (Russia)
Release form: solution for topical use

Active ingredient: benzyldimethyl

Miramistin belongs to the pharmacological group of antiseptics. This analogue of Derinat is active against a large group of bacterial agents, including staphylococcus, streptococcus, and some types of aerobic and anaerobic bacteria. Miramistin has an antiviral effect, suppressing the development of the immunodeficiency virus (HIV) and herpes.

The drug is widely used for various inflammatory diseases as a gargle or irrigator for tonsillitis and laryngitis. The Miramistin analogue is administered into the oral cavity by pressing the dispenser 3 times 3-4 times a day. When gargling, use 10–15 ml of the drug 3–4 times a day.

Rinofluimucil

Manufacturer: ZAMBON (Italy)
Release form: nasal spray

Active ingredient: acetylcysteine, tuaminoheptane

This analogue of Derinat belongs to a combination of drugs that eliminates swelling of the nasal mucosa, dilutes the thick secretion of a purulent mucous nature in the sinuses and nasal area, followed by its removal to the outside. Rinofluimucil actively relieves inflammation of the mucous membrane, restoring free breathing through the nose.

This analogue of Derinat is prescribed to adult patients 2 doses (2 presses on the sprayer) 3-4 times a day, and to children 1 injection into each nasal passage for 1 week.

Sialor

Manufacturer: UPDATE PFC (Russia)
Release form: tablets for solution, nasal spray

Active ingredient: silver proteinate

The active component included in Sialor has an astringent and anti-inflammatory effect. Is a good antiseptic. The analogue of Derinat Sialor prevents the multiplication of a viral pathological agent on the mucous membrane, forming a protective film on it.

The drug is used as a therapeutic and prophylactic agent for inflammation of the mucous membranes of the ENT organs. An analogue of Sialor is prescribed, 1–3 drops of a 2% solution prepared independently (1 tablet per 10 ml of solvent) in each nasal passage. Or 1 injection using a nasal spray.

Thymogen

Manufacturer: CITOMED (Russia)
Release form: nasal spray

Active ingredient: alpha-glutamyl-tryptophan

Thymogen belongs to the group of pharmacological agents that have an immunomodulatory effect. The medication stimulates cellular and humoral immunity, helping to increase the body's defenses in weakened and frequently ill patients.

Thymogen, as an analogue of Derinat drops, is indicated as a preventive and therapeutic agent for various viral infections that have an acute or chronic course. It can be part of complex therapy for diseases of bacterial origin.

The Thymogen analogue is used for adults in each nasal passage, 1 injection 2 times a day, and for children - 1 dose 1 time a day. The course of treatment lasts up to 1.5 weeks. To prevent viral infections, it is recommended to take an immunomodulator for up to 5 days.

Desrinitis

Manufacturer: Teva Pharmaceutical (Israel)
Release form: nasal spray

Active ingredient: mometasone

A synthetic drug with anti-inflammatory, antiallergic and glucocorticoid effects for local use. Desrinitis helps reduce inflammation of the mucous membrane and reduce the production of exudate. This analogue of Derinat is active not only at all stages of the development of an allergic reaction, but also during the healing of traumatic injuries to the nose.

The drug is indicated for adults, 2 injections into each nasal passage 1 time per day, and for children from 2 years of age, 1 dose 1 time per day, for treatment with an analogue of seasonal or year-round allergic rhinitis.

Derinat or Grippferon - which is better for adults and children?

Common over-the-counter immunomodulators include Grippferon, which is available in the form of nasal drops and nasal spray and is also used for therapeutic and preventive purposes for colds.

Both drugs are completely different in composition, but have a similar immunostimulating effect.

Grippferon, as well as Derinat, can be used for adults and children from birth. Both are well tolerated and almost never cause adverse reactions. Despite some similarities, the drugs also have differences.

Grippferon contains human recombinant interferon type alpha-2b, and Derinat contains sodium deoxyribonucleate. The first drug provides good protection when viral agents are introduced into the body. Its use activates immune cells that help fight pathogenic microorganisms.

Derinat, unlike Grippferon, has a wider spectrum of action, which helps to use it not only for colds, but also for many other diseases. The medicine is positioned not only as an immunomodulator, but also as a stimulator of regenerative processes and hematopoiesis.

It is used in various fields of medicine - ophthalmology, gynecology, surgery, gastroenterology. Grippferon does not have such properties, so we can conclude that Derinat is a stronger, more complex drug.

Despite the differences between the two drugs, they both nonspecifically activate the humoral and cellular components of the immune system, which helps to quickly cope with the disease and minimize possible complications.

A significant difference between the two drugs is that Derinat fights not only viruses, but also bacteria and fungi, while Grippferon is effective only against viral agents.

However, Grippferon's consumption is less - it can be used for no longer than seven days, then you should take a break. Derinat is intended for longer-term use - from 2 weeks to several months.

Therefore, if you choose Grippferon or Derinat for a child, it is better to choose the second drug.

For adults it is similar: Derinat interacts well with other medications and can increase their effectiveness. For example, when taken together with antibiotics, it is possible to shorten the duration of treatment, and in some cases, reduce the dose.

For adults, doctors prefer to prescribe Derinat, since it is a stronger drug with a complex effect on the patient’s body, who may have a history of other chronic pathologies.

Derinat or Interferon

Interferon, like Derinat, helps the body resist viruses, but doctors are confident that it should be used with extreme caution.

The reason for this is that interferon is part of the human immune system, and its direct infusion inhibits the production of its own interferon (the body, alas, is lazy).

Doctors believe that the use of Interferon should be resorted to only when emergency prevention is necessary.

It is advisable to take the drug when the disease has not yet occurred, and the person himself has been in contact with the patient. Interferon is recommended for children over 5 years of age.

Derinat has a broader spectrum of action (not only against viruses, but also against bacteria). It is often prescribed to children in whom viral infections provoke bacterial complications: sinusitis, nasopharyngitis, laryngitis. Its use reduces the risk of their development.

The advantage of Derinat is the absence of contraindications, as well as the possibility of use from birth. Interferon is an analogue cheaper than Derinat in the form of drops; it is not recommended to use it without consulting a doctor.

Rinofluimucil or Derinat

There is a significant difference between the medications. Rinoflumicil is a drug from the group of vasoconstrictors with a local mucolytic effect, and Derinat is an immunomodulator.

The first is used to treat ENT diseases - rhinitis, sinusitis, sinusitis. Its use can eliminate nasal congestion, thin mucus, and restore breathing. The product can be used only when the disease has occurred.

For the purpose of prevention, Rinoflumicil and its analogues are not prescribed, and treatment can last no more than 5 to 7 days. The drug is indicated for children from 3 years of age.

Derinat is a completely different medicine. Taking it will reduce the risk of developing ENT diseases and increase the body's resistance to infections that are treated with Rinoflumicil. The only similarity between the two medications is that they are both available in the form of nasal sprays.

Derinat or Vibrocil - which is better?

Manufacturer: GlaxoSmithKline (Russia)
Release form: nasal drops

Active ingredient: dimethindene, phenylephrine

Vibrocil is a combination drug that provides an antiallergic and vasoconstrictor effect for rhinitis of various etiologies. This Derinat substitute actively relieves swelling of the mucous membrane during a runny nose and nasal congestion. Despite similar indications for the use of both drugs, they have the following differences:

• Derinat can be prescribed to children from the first days of life, and it has practically no contraindications;
• Vibrocil in drops is approved for use only from 1 year, and spray and gel - from 6 years.

If a baby has a runny nose, then Derinat is better suited for treatment for such a child. For rhinitis of allergic origin, preference should be given to the analogue Vibrocil.

Derinat or IRS-19

An analogue of Derinat is IRS-19, which is also available in the form of a nasal spray, has an immunostimulating effect, but has a different composition.

So Derinat contains sodium deoxyribonucleate, of natural origin, and IRS-19 is a mixture of bacterial lysates, including streptococci, staphylococci, Haemophilus influenzae and some others. It is these microorganisms that most often cause respiratory tract diseases.

The similarity between the drugs under consideration is that they are indicated for the prevention and treatment of respiratory diseases and ENT pathologies, as well as for the restoration and stimulation of local immune functions.

However, Derinat is more often used for complex therapy than IRS-19, the effect of which can be observed at the beginning of the disease. Both drugs are prescribed to children, but IRS-19 has a wider range of contraindications and the risk of side effects. That is why when choosing two medications, it is better to pay attention to Derinat.

Derinat or Polyoxidonium – which is better?

Manufacturer: PETROVAX PHARM (Russia)
Release form: lyophilisate for the preparation of solution for injection and topical use

Active ingredient: azoximer bromide

Polyoxidonium is active as a drug used for the prevention and treatment of diseases of viral and infectious origin. The drug is approved for use in children from six months of age and can be part of complex therapy for diseases of various localizations.

Both drugs have a wide spectrum of action and indications. Polyoxidonium, as an analogue of Derinat in injections, is used to relieve acute manifestations of infections as a result of the introduction of a viral or bacterial agent. Parenteral administration of the analogue gives a faster effect compared to Derinat. In these cases, its analogue Polyoxidonium will be the best for the treatment of acute infectious conditions.