Prohibited during pregnancy
Has restrictions for children
Exoderil is an antifungal medication that is available in the form of a cream and solution for external use. The active component in the medicine is naftifine hydrochloride. Exoderil has a high cost, so it is worth knowing about cheaper analogues.
Packaging of the drug Exoderil
The drug is prescribed for the treatment of fungal diseases:
- athlete's foot;
- Athlete's foot
- trichophytosis;
- onychomycosis;
- damage to hair areas on the head;
- candidiasis;
- pityriasis versicolor;
- infection of the ear canal.
Exoderil is not prescribed for the following reasons:
- allergy to the medicinal composition;
- with open wounds.
The medication is used with extreme caution in pediatrics. During pregnancy and lactation, Exoderil can only be used under medical supervision.
The medicine is used externally only. The cream or solution is applied once a day to areas affected by fungi. The duration of the therapeutic course can last 7-30 days. Candidiasis is treated within 28-30 days. For onychomycosis, the cream is applied twice a day to the affected nails. Therapy can last up to six months.
To prevent recurrence of the pathology, it is necessary to continue to apply the medication for 2 weeks after the symptoms of the lesion disappear. Side effects when using Exoderil are quite rare: burning and hyperemia at the site of application, as well as rashes and itching.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Naftifine is a topical antimycotic that belongs to the class of allylamines. The mechanism of its action is associated with the ability to suppress the activity of the enzyme squalene-2,3-epoxidase, and thus inhibit the biosynthesis of ergosterol, which is part of the cell wall of the fungus.
The activity of the drug is manifested in relation to:
- dermatophytes (microsporum, epidermophyton, trichophyton);
- yeast fungi (Pityrosporum, Candida spp.)
- molds (Aspergillus spp.)
- other fungi (for example Sporothrix schenckii).
Naftifine against aspergillus and , and against yeast fungi - depending on the strain of the microorganism, it can exhibit both fungicidal and fungistatic activity.
It has antibacterial activity against Gram (+) and Gram (-) bacteria that can cause secondary infection , as well as an anti-inflammatory effect (which allows you to quickly eliminate the symptoms of inflammation, especially itching).
Pharmacokinetics
After application to the skin/nail, it penetrates well into their various layers and creates stable antifungal concentrations in them. naftifine is used externally, no more than 6% of the substance is exposed to systemic absorption.
The absorbed amount is partially metabolized and excreted in the urine and intestinal contents. T1/2 - 2-3 days.
pharmachologic effect
Manufacturer: SANDOZ (Austria)
Release form: solution and cream for external use
Active ingredient: naftifine
Analogues: Mikoderil, Naftoderil, Terbinafine
Thanks to the active substance, the medication slows down the growth of fungi and completely destroys them (fungicidal and fungistatic effect). The drug is effective against a number of dermatophytes, yeasts and molds.
Exoderil is also active against pathogenic microflora, which can provoke an inflammatory process.
Instructions for use of Exoderil (Method and dosage)
Cream Exoderil, instructions for use
When the fungal process is localized on the skin, it is recommended to apply the ointment to the affected area 1 r./day, covering the adjacent areas of healthy skin (approximately 1 cm at the edges of the affected area).
Before applying the cream, the affected area should be thoroughly cleaned and dried.
The duration of treatment for dermatomycosis is usually from 2 to 4 weeks, but if necessary it can be extended to 8 weeks, for candidiasis - 4 weeks.
For nail fungus, apply the cream 2 times a day. Recommendations on how to use the drug for onychomycosis indicate that before the first application of the product, use a nail file or scissors to remove as much of the affected part of the nail as possible. Treatment is long-term – up to six months.
Exoderil solution: instructions for use
For skin mycoses , Exoderil drops are used 1 r./day, for onychomycosis - 2 r./day. The affected area of the skin should be thoroughly washed and dried, the affected area of the nail should be removed as much as possible using a nail file or scissors (to facilitate the procedure, on the recommendation of a doctor, it is allowed to use special emollients).
The duration of therapy for dermatomycosis is up to 4-8 weeks, for fungal infections of the nails - up to six months.
For otomycosis, treatment should last at least 14 days. Treatment is carried out by placing turundas soaked in a solution into the ear. The duration of exposure is 5-8 minutes. You need to repeat the procedure 1-2 times a day.
Additionally
To prevent relapse, Exoderil (both cream and solution) should continue to be used for at least 2 weeks after the clinical symptoms of the disease have resolved.
special instructions
Drops and cream are not intended for use in ophthalmology , and therefore contact with the eyes should be avoided.
The medicine does not have a negative effect on the ability to drive a vehicle/mechanics.
What is better - cream or solution?
A special feature of the drug Exoderil is that in addition to the antimycotic effect , it also has antibacterial activity : the drug affects pathogenic microorganisms, often combined with fungal infections.
The solution penetrates well into the nail, being evenly distributed in it and helping to destroy the fungus, relieving inflammation and eliminating itching.
For some diseases (in particular, mycoses of the feet , when both the nail plate and the skin are simultaneously affected), both dosage forms are often used in combination: the nail is treated with a solution in the morning, and cream is applied to the skin in the evening.
In severe cases, in addition to topical therapy, systemic antimycotics (tablets, solution for infusion, powder for the preparation of oral suspension) may be prescribed.
Analogues of Exoderil
Level 4 ATX code matches:
Mikonorm
Undecin
Gentian violet
Zinkundan
Exiter
Batrafen
Lotseril
Lamisil Dermgel
Lamisil Uno
Lamisil
Salicylic acid
Salicylic ointment
Keto Plus
Exifin
Fungoterbin
Mycoseptin
Thermikon
Nitrofungin
Sulsena
Baziron AS
Ointment analogues: Mikoderil (synonym), Atifin , Batrafen , Lamisil , Mozoil , Terbizil , Fungoterbin , Tebikur .
Analogs of Exoderil in drops: Mikoderil (synonym), Lamisil Uno , Lotseril , Nitrofungin , Nichlorofen , Octicil , Saledez , MC Peel .
Analogs are cheaper than Exoderil
Cheap analogues of Exoderil are domestically produced drugs. Analogues produced by Russian companies may contain the same active ingredient, but their price will be lower in comparison with foreign products.
The first and only substitute for Exoderil in Russia is the drug Mikoderil . A one percent solution of Mikoderil can be purchased from 380 rubles, cream - from 290 rubles.
The price of Russian analogues with a similar mechanism of action is from 60 rubles.
Which is better: Loceril or Exoderil?
Loceryl is an antifungal nail polish whose active ingredient is amorolfine .
Amorolfine is used for fungal nail infections caused by Epidermophyton, Trichophyton, Mycrosporum, Coccidoides, Cryptococcus, Wangiella, Pityrosporum, Candida, Hendersonula, Histoplasma, Sporothrix, Alternaria, Cladosporium, Fonseceae, Scopulariopsis.
naftifine it contains .
Since the drugs differ in composition, it is not entirely correct to judge which is more effective - Exoderil or Loceril .
Loceryl is used to treat nail fungus , its analogue can be used both for the treatment of nail fungus and for the treatment of dermatomycosis . Moreover, the solution penetrates the nail plate better than varnish and acts the same regardless of whether the structure of the nail is damaged or not.
The disadvantages of nail polishes are their inability to penetrate into the channels of the nail plate, as well as into loose and crumbled nail plates.
Reviews allow us to conclude that Exoderil is quite effective against infections caused by the most common fungi today, however, it is powerless against some organisms that its analogue can easily cope with.
Thus, the choice in favor of one or another remedy must be made taking into account the diagnosis, pathogen and degree of damage.
Mikozan or Exoderil - which is better?
The drug Mikozan is a kit for removing fungal infections from the nail. The product is available in the form of a serum and is supplied with disposable nail files and an applicator brush, which makes it easier to apply the medicine to the affected nail.
The active substance of Mycozan is rye enzyme filtrate. When applied to the nail, the drug has a local antifungal effect , while increasing the density of the nail plate, reducing its porosity and creating conditions unfavorable for the growth of pathogenic fungi.
Experts often recommend using Mikozan for prevention, however, patients who have used this drug for treatment speak of it as an effective and really helpful remedy when it comes to onychomycosis .
If the affected area is not limited to the nail, then it is more advisable to use Exoderil to treat adjacent areas of the skin.
Exoderil or Lamisil - which is better?
Manufacturer: GlaxoSmithKline Healthcare (Russia)
Release form: cream for external use
Active ingredient: terbinafine
Both drugs have different active substances and mechanism of action, but the same treatment result.
Exoderil will be more effective than its analog Lamisil, since it not only destroys different types of fungus. Exoderil is also universal, as it has additional antibacterial, anti-inflammatory effects and can be used to treat skin and nail fungus.
Use during pregnancy
Provided that the drug is used in accordance with the recommendations given in the instructions, its effect on the fetus/newborn is unlikely.
The results of teratogenicity studies indicate that there is no risk of any embryotoxic effects.
During pregnancy and breastfeeding, the medicine can be used only after a thorough assessment by the doctor of the expected effect of therapy/risk ratio.
Breastfeeding women should avoid getting the solution/cream on the skin and in the baby's digestive tract.
Reviews about Exoderil
Reviews about Exoderil cream, as well as reviews about Exoderil solution, can be found on forums that are different: for some, this drug helps restore the health of their nails and skin, for others, on the contrary, even after 2-3 months of using the product, there is no improvement notices.
Experts say that you can get rid of nail/skin fungus only if the treatment is carried out correctly.
Since in case of fungal infections of the feet, the pathological process in about half of the cases spreads to the nails, it is considered advisable to combine ointment and drops: for example, the solution for nail fungus is used in the morning, and at night the skin and affected nail plates are treated with cream.
Any external remedies (drops, cream or varnish) against nail fungus should be used regularly and over a long period of time.
At the same time, it is very important (especially during the treatment period) to properly care for your nails/skin (for example, once a week, give your nails a bath with soda and laundry soap), do not forget about personal hygiene and the need to disinfect all surfaces in contact with the fungus.
In severe forms of fungal infection, topical antimycotic drugs (Exoderil or its analogues) are combined with systemic drugs to achieve a positive effect.
Exoderil or Lotseril - which is better and more effective
Manufacturer: GALDERMA (Switzerland)
Release form: varnish
Active ingredient: amorolfine
How to replace Exoderil if the fungal infection is localized on the nail plate of the hands? A convenient and effective medication for the treatment of this pathology is the analogue of Exoderil lacquer Loceril. This substitute for the base drug is applied to the affected nail 1-2 times a week, and Exoderil - 2 times a day.
The effect of using the base drug occurs faster than from its analogue. In addition, it is significantly inferior to it in price. But after treatment with Exoderil, a relapse may develop. It will be more convenient and effective to treat nail fungus with Loceryl.
How much does Exoderil cost?
Cost of the drug in Ukraine
The price of Exoderil in Kyiv is from 117 UAH. Ointment in tubes of 15 g can be bought for an average of 130 UAH. The price of Exoderil 10 ml in Ukraine is from 150 UAH, the medicine in 20 ml bottles in Dnepropetrovsk, Kharkov, Odessa or Zaporozhye costs 305-310 UAH.
Cost of the drug in Russia
You can buy Exoderil in Moscow at a price of 425 rubles: the price of Exoderil cream 15 g is 425-530 rubles, 30 g is 770-830 rubles; the price of Exoderil solution 10 ml is 510-710 rubles, drops in 20 ml bottles cost 860-1020 rubles.
Systemic agents (tablets, solution, etc.) are not produced under the Exoderil brand. You can treat nail fungus using both dosage forms of the drug according to the scheme: cream in the evening, solution in the morning.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Exoderil varnish for nail fungus 5% bottle 2.5 ml
RUB 2,780 order
ZdravCity
- Exoderil solution for external use. approx. 20ml Globopharm Pharmaceuticals Products/Sandoz GmbH
RUB 1,061 order
- Exoderil solution for external use. approx. 1% 30ml Globopharm Pharmaceutical Products/Sandoz GmbH
RUB 1,406 order
- Exoderil solution for external use. approx. 1% 10ml Globopharm Pharmaceutical Products/Sandoz GmbH
570 rub. order
- Exoderil cream for external use 1% 30g Salutas Pharma GmbH
780 rub. order
- Exoderil cream for external use 1% 15g Salutas Pharma GmbH
RUR 526 order
Pharmacy Dialogue
- Exoderil cream (tube 1% 30g)Merck KgaA
RUB 883 order
- Exoderil solution (vial 1% 30ml)Sandoz
RUB 1,373 order
- Exoderil solution (vial 1% 30ml)Sandoz/Globopharm
RUB 1,419 order
- Exoderil cream tube 1% 15gMerck KgaA
RUR 494 order
- Exoderil solution 1% 10mlSandoz
RUR 578 order
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Pharmacy24
- Exoderil Nail polish medicinal 5% 2.5 ml solution Lek pharmaceutical company d.d., Slovenia
327 UAH.order - Exoderil 1% 20 ml cutaneous solution Globofarm Pharmaceutical Products und Gandelsgesellschaft mbH/Sandoz GmbH, Austria/Austria
283 UAH order
- Exoderil 1% 10 ml cutaneous solution Globofarm Pharmaceutical Products und Gandelsgesellschaft mbH/Sandoz GmbH, Austria/Austria
179 UAH. order
- Exoderil 1% 15 g cream Merck KgaA & Co. Werk Spittal, Austria/Sandoz GmbH, Austria/Salutas Pharma GmbH, Nimecchina
128 UAH order
PaniPharmacy
- Exoderil nail polish 5% fl. 2.5 ml No. 1
366 UAH order
- Exoderil liquid Exoderil solution for external use 1% 10ml Austria, Sandoz
222 UAH order
- Exoderil cream Exoderil cream for external use 1% 15g tube Austria, Sandoz
142 UAH order
- Exoderil liquid Exoderil solution for external use 1% 20ml Austria, Sandoz
297 UAH order
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Exoderil or Mycoderil - which is more effective and better against fungus
Manufacturer: PHARMSTANDARD-LEKSREDSTVA (Russia)
Release form: solution for external use, cream
Active ingredient: naftifine
Both drugs have the same active ingredient and an equivalent mechanism of action. The therapeutic effect is observed after a few days, when the process of inflammation and itching begins to subside.
According to doctors, both medications give good treatment results and differ from each other only in cost. You can buy this Russian substitute for Exoderil for nails cheaper , but with the same effectiveness as the basic drug.
