PENTALGIN-N tab N10

A drug for the treatment of pain - domestic tablets Pentalgin. The manufacturer advertises them as a powerful pain reliever.

The chief physician of Cleveland Hospital, Josie Znidarich, is confident that the intensity of pain depends on the general condition of the body and the degree of damage. The most severe syndrome is with previous illnesses, a weakened body, and fear.

Pharmacodynamics and pharmacokinetics

The medicine has the following effects:

antipyretic
anti-inflammatory
anesthetic
pasmolytic

The substances included in the medication explain the therapeutic effect of Pentalgin.

Wikipedia states that paracetamol is an analgesic-antipyretic that can have analgesic and antipyretic effects. These effects are achieved thanks to the blockade of COX in the nervous system, affecting pain centers and thermoregulation.

Caffeine is a psychostimulant and helps dilate blood vessels in the muscles, kidneys and heart. Among other things, caffeine helps improve performance, reduce fatigue and tiredness, and provides a tonic effect.

The substance Naproxen provides the following actions:

analgesic
antipyretic
anti-inflammatory

Pheniramine is a histamine H1 receptor blocker. Thanks to it, an antispasmodic and mild sedative effect occurs. The substance can improve the healing properties of paracetamol.

Drotaverine provides a myotropic antispasmodic effect.

The cheapest similar products

Domestic analogs are much cheaper than Pentalgin, but the effectiveness of these drugs, according to experts and patients, is also quite high.

Sedalgin Plus

Sedalgin Plus is an analgesic drug with anti-inflammatory properties and an antipyretic effect. A medicine is made based on metamizole, caffeine and thiamine in tablets and is used in the treatment of:

headache and migraine pain;
degenerative or inflammatory changes in the muscle fibers and in the patient’s skeleton;
dysmenorrhea;
neuritis, arthritis, polyarthritis and neuralgia;
sciatica, radiculitis, lumbago, arthrosis and osteochondrosis;
polyneuropathy of various origins.

Sedalgin is not prescribed for:

sensitivity to ingredients in the medicine;
agranulocytosis, anemia and leukopenia;
liver failure and kidney dysfunction;
infectious neuropenia;
bronchospasms, pulmonary edema and asthma;
disturbances in myocardial rhythm;
ulcerative and erosive destruction in the gastrointestinal tract;
glaucoma;
insomnia, nervousness and irritability;

Sedalgin is also not used in children under 12 years of age, during lactation and pregnancy.

It is necessary to take 0.5-1 tablet once a day for 3 days. For severe pain, you can increase the frequency of use up to 2-4 times. The maximum daily dosage is 4 tablets.

Negative effects:

dyspepsia;
allergy;
thrombocytopenia and anemia;
pressure fluctuations and arrhythmia.

Citramon

Citramon is a combined analgesic and antipyretic drug with acetylsalicylic acid (ASA), paracetamol and caffeine.

Citramon is used to relieve:

dental, migraine, headaches and menstrual pain;
neurotic pain in joints, muscle fibers and back;
post-traumatic pain.

You cannot use Citramon for:

intolerance to components in the medicine;
kidney/liver dysfunction;
ulcers and erosions in the digestive organs;
aspirin asthma;
hemophilia, anemia, thrombocytopenia;
hypertension and myocardial arrhythmias;
aortic aneurysm with risk of dissection;
gout

The medication is not prescribed in pediatrics, women during pregnancy and while breastfeeding a newborn.

The drug therapy regimen is 2-3 doses per day, 1 tablet.

Adverse reactions:

hypertension and insomnia;
arrhythmia and tachycardia;
bronchospasms;
dizziness;
skin allergies;
dyspepsia;
anemia.

Andipal

Andipal is a combination drug that contains bendazole, metamizole sodium, phenobarbital and papaverine. The medicine has the following properties:

vasodilating and analgesic;
antispasmodic and sedative;
antipyretic and anti-inflammatory.

Andipal is prescribed for:

spasms of peripheral vessels and cerebral arteries;
pain and spasms in the digestive system;
spasms in the urological and genital organs;
pain in muscles, bones and joints;
hypertensive crisis as part of combined treatment with antihypertensive medications and diuretics.

It is prohibited to prescribe medicine for:

hypersensitivity to the ingredients in the medication;
kidney/liver failure;
pathologies in hemostasis;
tachyarrhythmias and heart failure;
paroxysmal angina;
glaucoma;
prostate hyperplasia;
megacolon;
pregnancy;
lactation, as well as in children under 8 years of age.

Medication regimen for patients over 18 years of age:

1-2 tablets 2-3 times a day;
The daily maximum of tablets is 6-7 pieces.

For children over 8 years of age, this dosage should be divided in half. You can take 1 tablet twice a day or 0.5 tablets four times a day.

When taken in therapeutic dosages, Andipal does not provoke negative effects.

Pentalgin or Tempalgin – which is better?

Manufacturer: Sopharma, Bulgaria
Release form: tablets

Active ingredient: metamizole sodium, triacetonamine-4-toluenesulfonate

An analogue of Pentalgin in tablets is the drug Tempalgin, consisting of an analgesic with antispasmodic activity metamizole sodium and an anxiolytic. It is used for various pains and spasms, produced by the Bulgarian pharmaceutical company Sopharma.

Pentalgin - 5 components without codeine, aimed at eliminating pain and spasms. Produced by the Russian manufacturer Pharmstandard (Kursk). Indications: any pain and spasms.

Patients often confuse Pentalgin and Tempalgin. The first drug is available in boxes of 12 and 24 oblong green tablets. Contraindicated in children. Tempalgin – green round tablets in blisters of 10 pieces, sold in boxes of 20 and 100 tablets. Can be used from 14 years of age.

Both drugs have proven themselves and effectively cope with pain. Not suitable for long-term use, more than 5 days. The cost of the analogue Pentalgin N is up to 3 times lower in terms of 10 tablets.

Whichever is stronger is better for menstruation and headaches individually. Depends on the nature and cause of the pain syndrome.

Pentalgin or Ibuprofen - which is better?

Manufacturer: Synthesis, Ozon, etc., Russia
Release form: tablets, capsules, gel, suspension

Active ingredient: ibuprofen

Ibuprofen is an anti-inflammatory, antipyretic and analgesic drug for use in children and adults. It is used for feverish syndrome and various pains.

Pentalgin is stronger. It is a combined analgesic and antispasmodic and is not used in children.

Pentalgin analogues that are cheaper or more expensive in price will not always be more effective. The choice of drug should be made based on the intensity of pain, previously used analgesics, and the age of the patient. Before purchasing, read the instructions and exclude contraindications. The maximum time for using an analgesic without a doctor’s prescription is up to 5 days, an antipyretic drug is up to 3 days.

Indications for use of Pentalgin

The drug contains 5 components aimed at relieving pain and improving the general condition of the patient. Range of applications:

pain of various origins - joint, dental, muscle, headache, during menstruation, etc.;
colic – with pancreatitis, cholecystitis;
symptomatic treatment of ARVI and influenza;
inflammation and pain in the postoperative period;
injuries.

The gel is applied topically for diseases of the musculoskeletal system, accompanied by pain, inflammation and swelling. Also used for injuries, sprains, bruises. Do not apply to open wound surfaces.

Does Pentalgin help with toothache or not?

The medicine is used for acute toothache, relieves it, reduces inflammation and swelling in the affected area. The duration should not exceed 5 days; you should visit the dentist to determine the cause and eliminate it.

Also, the medication can be used for the eruption of wisdom teeth in adults, after installation of a filling.

Side effect

It is possible that therapy with Pentalgin will cause certain negative effects:

allergy
changes in the functioning of the cardiovascular, digestive, nervous, and genitourinary systems

The above effects manifest themselves as:

arrhythmias
increase in pressure
irregular heartbeat
anemia
skin rash
itching
headache
tremor
angioedema
constipation
erosive and ulcerative gastrointestinal disorders

Overdose

Using large dosages leads to:

confusion
tachycardia
epilepsy
excitement
excessive concern
anorexia
pale skin
pain in the abdomen

More dangerous signs of overdose include:

coma
death
pancreatitis
arrhythmia
encephalopathy
liver failure

If there are symptoms of overdose, it is important to perform gastric lavage, take activated charcoal and carry out symptomatic treatment.

Analogues in other dosage forms

On the pharmaceutical market there are drugs similar to Pentalgin, which are manufactured in the following dosage forms - gels and ointments, capsules, suppositories and oral suspensions.

Artrosilene

Artrosilene is an analgesic and a substitute for Pentalgin. The medicine is produced in several dosage forms - capsules, parenteral solution and gel, aerosol and suppositories. The active ingredient is ketoprofen lysine salt.

Artrosilene is prescribed after operations and injuries, as well as for the following pathologies:

rheumatism of different localization;
osteoarthritis and spondyloarthritis;
gout and inflammatory processes in periarticular tissues;
inflammation of various etiologies and locations in the musculoskeletal system.

Parenteral solution is used to relieve acute and severe pain.

Artrosilene is not used for:

aspirin asthma;
sensitivity to the ingredients of the medication;
Crohn's disease;
severe pathologies of the digestive system;
hemophilia;
renal dysfunction;
pregnancy;
lactation.

Dosage for oral use – 1 capsule once a day after meals. The medication course can last 90-120 days. For parenteral use - 2 administration procedures per day, 1 ampoule intravenously for 1-3 days. Further treatment can be continued with oral medication or rectal suppository therapy.

Adverse reactions can manifest themselves in the form of allergies, disorders of hematopoiesis and blood flow, in the functioning of the heart, central nervous system and gastrointestinal tract.

Ketonal

Ketonal is an analgesic medication that is produced in capsules and rectal suppositories, in tablets and in a solution for injections based on ketoprofen. Ketonal is used in therapy:

arthritis and arthrosis;
gout and spondyloarthritis;
bursitis and tendonitis;
dysmenorrhea.

The drug is also prescribed in the post-traumatic and post-operative periods.

Contraindications for use:

intolerance to components in the medicine;
peptic ulcers in the digestive system and non-ulcer dyspepsia;
predisposition to bleeding;
liver and kidney failure;
bronchial asthma.

Also not used in the treatment of children under 14 years of age, women during lactation and pregnancy.

Oral dosage – 1-2 capsules (tablets) 2-3 times a day. Suppositories are used once a day, 1 suppository. The solution is used in a hospital setting 1-3 times a day, 0.1 g deep IM.

Adverse reactions:

dyspepsia;
anemia and dizziness;
nosebleeds and petechiae;
bronchospasms and urticaria.

OKI

OKI is an analgesic and a substitute for Pentalgin with anti-inflammatory and antipyretic properties. An analogue of Pentalgin is produced in suppositories, in solution, gel and in granules for the preparation of an oral suspension with the active ingredient - ketoprofen lysine salt.

Prescribed to adult patients and children with the following pathologies:

rheumatoid etiology arthritis and spondyloarthritis;
osteoarthritis and gout;
otitis and diseases in the skeletal and muscular system.

A solution for topical use is prescribed for:

ENT pathologies – sore throat, tonsillitis, laryngitis and pharyngitis;
stomatitis and periodontal disease;
glossitis and gingivitis;
periodontopathy.

OKI is not prescribed for:

hypovolemia;
ulcerative and erosive destruction of the gastrointestinal tract;
aspirin triad;
intolerance to medicinal components;
kidney problems and liver failure;
open wounds and hemorrhoids (for suppositories and gel).

For adult patients and children over 14 years of age, it is necessary to take a double sachet of granules three times a day (1 dose - 80 mg), dissolved in 100 ml of water. For children 6-14 years old - dissolve half a packet (0.5 doses - 40 mg) in 100 ml of water, also 3 times a day.

Suppositories (1 suppository) are used 2-3 times a day. Solution for topical use – 2 rinses per day. Children need 1 injection of solution (2 ml), over 12 years old - 3 injections (6 ml), and adults 5 injections (10 ml). The solution must be diluted in a measuring cup and used for dental and ENT pathologies.

Contraindications for taking Pentalgin

The pharmaceutical product is not prescribed for:

intolerance to its components
internal bleeding of the gastrointestinal tract
arterial hypertension
under 18 years of age
peptic ulcers of the gastrointestinal tract
pathologies of the heart and blood vessels
pregnancy, breastfeeding (if pain occurs, pregnant and nursing mothers should consult a doctor to receive safe treatment)
liver and kidney failure (severe form)
bronchial asthma
hyperkalemia
undergone coronary artery bypass surgery

Doctors prescribe medication with caution for:

diabetes mellitus
viral hepatitis
elderly patient
liver damage and ethanol
cerebrovascular pathologies
mild to moderate forms of liver or kidney failure
epilepsy

pharmachologic effect

Manufacturer: Pharmstandard, Russia
Release form: tablets

Active ingredients: paracetamol, naproxen, caffeine, drotaverine, pheniramine

The medicine in tablets contains 5 active ingredients. Has the following properties:

relieves pain and spasm;
lowers temperature;
fights the inflammatory process;
dilates blood vessels;
eliminates fatigue, drowsiness;
increases performance;
in case of ARVI, it reduces lacrimation and nasal discharge.

The components of the drug are carefully selected, and together they enhance the healing properties of each component.

The form for topical use Pentalgin extra-gel contains the main component ketoprofen. It fights swelling, inflammation and pain.

Additional substances also help improve the patient’s condition, increase joint mobility, and effectively penetrate the medicine into the tissues. These include tincture of capsicum, camphor, dimexide, peppermint oil.

Pentalgin increases or decreases blood pressure
Because the medicine contains caffeine and pheniramine, it increases blood pressure. Contraindication: severe form of hypertension.

When is Pentalgin prescribed?

Indications for use of Pentalgin:

neuralgia
pain during menstruation
migraine
toothache
joint or muscle pain
algomenorrhea
cold, in the presence of elevated body temperature
post-operative or post-traumatic pain
pain due to spasm of smooth muscles, caused by renal colic, cholelithiasis, chronic cholecystitis.

Substitutes for Pentalgin according to therapeutic effect and indications

Substitutes for Pentalgin in terms of therapeutic effect are medications with different compositions, but having the same therapeutic direction as Pentalgin.

Sedal M

Sedal M belongs to the group of non-opioid analgesics. The drug is produced in tablets with the following composition: metamizole + phenobarbital + paracetamol + caffeine + codeine.

Prescribe medication for:

headache and migraine pain;
degenerative pathologies of the musculoskeletal system;
inflammation in the muscular and skeletal apparatus of the human body;
neuropathy, neuralgia and radiculitis;
plexitis, polyneuritis and neuritis;
dysmenorrhea.

Sedal M is also used in the postoperative period to reduce pain and swelling.

Sedal is not prescribed for:

allergies to the medicinal composition;
severe renal and hepatic pathologies;
leukopenia, thrombocytopenia and agranulocytosis;
different etiologies of anemia, hemophilia;
neuropenia of infectious origin;
allergic rhinitis, bronchospasms, conjunctivitis and bronchial asthma;
cardiac pathologies – mitral valve stenosis, arrhythmia, coronary artery disease, malignant hypertension, heart attack;
porphyria;
glaucoma;
ulcerative destruction in the gastrointestinal tract;
diabetes mellitus;
myasthenia gravis;
alcoholism;
disorders in the respiratory system, shortness of breath.

Also, the medicine is not prescribed after a skull injury, to patients in childhood (up to 12 years) and old age, as well as to women during the period of bearing and feeding a child with breast milk.

Sedal should be taken orally 1-3 times a day, 1-2 tablets. The maximum daily dosage is 6 tablets. Therapy lasts on average 1-3 days.

Side effects:

nystagmus, diplopia, ataxia and dizziness;
depression, overexcitement, insomnia and seizures;
dyspepsia and intestinal obstruction;
skin allergy.

Spazgan

Spazgan is a combined antispasmodic drug with active ingredients: metamizole sodium, fenpiverinium bromide and pitofenone. The antispasmodic is produced in a solution for injections and in tablets.

Spazgan is used for:

colic in the liver and gall bladder;
renal colic and in the intestines;
dysmenorrhea;
spasms of cerebral vessels and internal organs.

Spazgan is also prescribed for the relief of muscle and joint pain for:

myalgia and neuralgia;
arthritis and arthrosis;
osteochondrosis, sciatica and lumbago;
rheumatic pain of various locations.

Do not use the medication if:

heart failure in the decompensated phase and ischemic heart disease;
tachycardia, bradycardia, arrhythmia, extrasystoles, fibrillation;
kidney and liver dysfunction;
disorders in hemostasis;
glaucoma;
megacolon;
prostatitis.

It is prohibited to use Spazgan in childhood (under 8 years), in the treatment of women during pregnancy and breastfeeding.

Tablets are used in the treatment of children from 15 years of age and adults, 1-2 tablets three or four times a day. The duration of therapy with solution and tablets is 3-5 days. The injection solution is prescribed after 8 years, 2-4 ml per day with the frequency of drug infusion - 2-4 procedures per day.

Side effects:

epigastric and abdominal pain;
urticaria, skin hyperemia, itching and rash;
hypotension and myocardial rhythm disturbance;
bronchospasms and dizziness.

Kaffetin

Caffetin is a medication with analgesic properties. The active ingredients in the medication are propyphenazone, paracetamol, caffeine and codeine. Caffetin is produced in tablets with different dosages of the main component. Caffetin Light is approved for use by children over 7 years of age.

Caffetin is prescribed for:

headache, migraine, dental, joint and muscle pain;
arthralgia, neurology;
post-traumatic pain;
algodismenorrhea.

It is forbidden to use Caffetin for:

allergies to medicinal composition;
hepatic and renal dysfunction;
disorders in the hematopoietic system;
depression, panic, apathy and agoraphobia;
hypertension and atherosclerosis;
myocardial infarction, arrhythmias;
insomnia.

Prescribed with restrictions for:

abdominal pain of unknown origin;
convulsions;
bronchial asthma;
alcoholism;
hepatitis and glaucoma;

Caffetin is not used in the treatment of pregnant women and breastfeeding, as well as in pediatric practice under 12 years of age. After 16 years, 1-2 tablets are prescribed three times a day. Children over 12 years old – 2-3 doses per day, 1 tablet. The duration of therapeutic treatment is 3-7 days.

Side effects occur infrequently and are expressed in skin allergies, drowsiness or insomnia, increased blood pressure and tachycardia, and dyspepsia.

Drotaverine

It is an antispasmodic that is used in the treatment of diseases of the urological and digestive organs. Drotaverine is produced in tablet form based on drotaverine.

Drotaverine is prescribed for:

cholecystitis and papillitis;
urethritis, pyelonephritis and cystitis;
tenesmus in the bladder;
dysmenorrhea;
gastritis, pancreatitis, erosions and ulcers in the gastrointestinal tract;
flatulence and severe constipation;
headaches of vascular and neurotic origin.

Drotaverine is prescribed for:

sensitivity to the drug composition;
liver, heart and kidney failure;
glaucoma.

The medicine is not used in pediatric practice under 6 years of age, in elderly patients and during lactation.

Prescribed with great caution when:

hypertension and atherosclerosis of the coronary arteries;
prostate hyperplasia;
pregnancy.

Adult dosages of the drug are 40-80 mg, 2-3 doses per day. Children's dosages 6-12 years – 20-40 mg 1-2 doses per day.

Adverse reactions:

urticaria, rash, anaphylaxis, dermatitis;
dizziness and headache;
tachycardia, arrhythmia, decreased blood pressure;
dyspepsia.

Spasmalgon

Spasmalgon is produced on the basis of fenpiverinium bromide, metamizole sodium and pitofenone and is a combined antispasmodic drug that is available in parenteral solution and tablets.

The medicine is used for:

dysmenorrhea and pain in the genitourinary organs;
pain in muscle fibers and joints;
colic in the gastrointestinal tract.

Spasmalgon is not used in therapy for:

prostatitis;
thrombocytopenia, anemia and leukopenia;
hemophilia;
allergies to ingredients in Spazmalgon;
neuropenia;
asthma and heart rhythm disturbances.

Also not prescribed in pediatrics to patients under 15 years of age, women during pregnancy or breastfeeding.

The dosage of the medication is 1-2 tablets per day. The duration of the course of therapy is up to 3 days. The solution is administered twice or thrice a day, 2-5 ml intravenously or intramuscularly for 3-5 days.

Adverse reactions:

urticaria, rash, itchy skin;
bronchospasms and rhinitis;
dyspepsia;
blood pressure fluctuations and tachycardia.

Novigan

Novigan is produced in tablets with the active ingredients - ibuprofen, fenpiverinium bromide and pitofenone. Novigan is a combined antispasmodic, which is prescribed for the treatment of pain of moderate intensity in the urinary system and gastrointestinal tract, as well as muscle spasms, joint pain and headaches.

Novigan is not used in the treatment of patients with sensitivity to the drug composition, as well as with ulcerative processes and inflammation in the gastrointestinal tract, with severe liver problems, and kidney dysfunction. It is not recommended to take the medication if there are disturbances in hemostasis after aortic valve surgery. It is strictly forbidden to prescribe to children under 16 years of age, pregnant women and lactation.

The medication must be taken orally four times a day, 1-2 tablets for 3 days.

Negative reactions:

dyspepsia;
bronchospasms;
hives.

Ketanov

Ketanov is made on the basis of ketorolac trometamol and is an analgesic drug. The medication is available in parenteral solution and tablets. It is used for moderate and severe pain of various locations and etiologies, as well as in the postoperative period and for oncological tumors.

It is prohibited to prescribe Ketanov for:

hemophilia and abnormalities in hemostasis;
hypovolemia;
bronchospasms;
peptic ulcers in the digestive organs;
severe liver and kidney diseases;
hemorrhagic stroke.

Also not prescribed in pediatrics under 16 years of age, for women during breastfeeding and during pregnancy.

Take 1 tablet orally once a day. For severe pain, you can take it 3-4 times a day. The duration of therapy should be no longer than 5 days.

With a one-time use, Ketanov does not cause side effects; allergic reactions and bronchospasms can develop with prolonged and uncontrolled use.

Pentalgin or Nurofen – which is better?

Manufacturer: Reckitt Benckiser Healthcare, UK
Release form: capsules, tablets, suspension, suppositories, gel

Active ingredient: ibuprofen

Synonyms: Mig 400, Ibuprofen, Maxicold for children, Brufen, etc.

Pentalgin can be replaced with Nurofen if there is intolerance to the components, high blood pressure, or the patient is a child. The analogue Nurofen is used in pediatrics from 3 months in the form of suppositories and syrup; capsules and tablets differ in the dose of the active component, strength of action and speed.

Nurofen is used for toothache and headaches, diseases of the musculoskeletal system, and fever.

Pentalgin is more powerful because it contains 5 components. They enhance the therapeutic effect and allow you to reduce the dose of each component. Disadvantage: limited use in childhood.