It happens that animals develop genital diseases. If left untreated, the risk of death and infertility increases. To prevent this, doctors use the hormonal drug Sinestrol. The beneficial effects of this medicine can bring the animal's health back to normal. But you need to know in detail for which cases it is applicable and for which it is not.
Composition and description of the medicine
The drug in international pharmacology is called hexestrol-2%. It first became available for purchase in 1923. For its creation, scientists received the Nobel Prize.
The substance consists of hexestrol-2 percent, vegetable and olive oil. This is a golden-colored oil solution that does not dissolve in water.
Sinestrol for animals was created artificially. Made on the basis of the female sex hormone estrone. The drug is distinguished by its fast and effective effect on the animal’s body.
On the pharmacological market it is sold in glass flasks. The volumes are written on the packages - 1, 5 and 10 ml. To maintain the tightness of the stoppers, the medicine is produced with rubber stoppers, which are secured with protective aluminum caps.
How the drug works
After the medicine enters the animal’s body, its main substance, together with the natural hormone estrone, begins to return the processes of the menstrual cycle to normal. What causes the medicine in the body of a sick animal? Geksestrol improves blood flow to the genitals , increases the number of elements of the muscular layer of the uterus, and activates the endometrium. Doctors also note a positive effect on the mammary glands. The sensitivity of the genital organs increases. The substance reaches all organs and tissues in a short time.
"Sinestrol" is intended for pigs, goats, cows, dogs, cats, sheep.
Before starting to use the medicine, you need to make sure that the animal’s temperature is raised to 37-40 degrees Celsius. It is administered in two ways: intramuscularly and subcutaneously. There are no tablets for sale.
Sinestrol solution d/in in oil 2% 1 ml x10
Trade name: Synoestrol International name: Hexestrol
Release form: solution for injection in olive oil 0.1%, 2% (ampoules) 1 ml
Composition: hexestrol 1/20 mg - 1 ml
Pharmacological group: estrogen analogue of non-steroidal structure
Pharmacological group according to ATK: G03CA (Natural and semi-synthetic estrogens)
Pharmacological action: estrogenic,
Indications: Ovarian hypofunction (amenorrhea, hypomenorrhea, oligomenorrhea, dysmenorrhea), infertility, vaginitis (in girls and in old age), genital hypoplasia, sexual infantilism, secondary estrogen deficiency, post-castration and menopausal disorders, weakness of labor, post-term pregnancy, virile hypertrichosis in women, the need to suppress lactation. Breast cancer, prostate hypertrophy, prostate cancer (in complex therapy - surgical treatment, radiation therapy) - 2% solution.
Dosage regimen: For hypoplasia of the genital organs, congenital amenorrhea and a severely underdeveloped uterus, administer 1-2 mg intramuscularly or orally, 2 mg 1-2 times a day daily for 4-6 weeks or more. If there is an effect, then progesterone (5 mg per day IM) or pregnin (10 mg 3 times a day orally) is prescribed for 6-8 days. If necessary, courses of hormone therapy are repeated. For secondary amenorrhea, 1-2 mg per day is prescribed for 15-20 days, then progesterone or pregnin at the indicated dose for 6-8 days. For hypo-, oligomenorrhea - intramuscularly or orally, 1 mg every day or every other day during the first half of the intermenstrual period, for infertility due to underdevelopment of the uterus - 1 mg intramuscularly or 1-2 mg orally in the first 7- 8 days after menstruation, for menopausal disorders - orally, 0.5-1 mg. To reduce lactation in women in the postpartum period, it is prescribed orally, 1 mg 2 times a day or intramuscularly, 1 ml of a 0.1% solution once a day for 2 days, to completely suppress lactation - 2-3 mg per day or 1 ml of 0.1% solution 2 times a day for 5-7 days. For breast cancer in women over 60 years of age, a 2% solution is administered intramuscularly daily, starting at 20 mg/day, then the daily dose is gradually increased to 100 mg, and the optimal dose is selected and administered over a long period of time. For prostatic hypertrophy - 40 mg IM daily for 30 days, another 2-3 courses of 20 days each at intervals of 2-3 months are administered throughout the year. For prostate cancer - daily 60-80 mg IM for 2 months, then 10-20 mg per day IM or orally. The total dose and duration of treatment depend on changes in the prostate gland, the presence or absence of metastases, general condition and the degree of feminization. Higher doses for adults. IM: single dose - 2 mg (2 ml of 0.1% solution), daily dose - 3 mg. In the treatment of malignant neoplasms, the highest single dose is 60 mg (3 ml of a 2% solution), the highest daily dose is 100 mg (5 ml of a 2% solution).
Contraindications: Hypersensitivity, pregnancy, estrogen-dependent malignancies or suspicion of them, unusual or undiagnosed genital or uterine bleeding, thrombophlebitis or thromboembolic diseases in the active phase (except for the treatment of breast and prostate cancer). Carefully. Thrombophlebitis, thrombosis or thromboembolism (with a history of taking estrogen), familial hyperlipoproteinemia, pancreatitis, endometriosis, history of gallbladder disease (especially cholelithiasis), severe liver failure, jaundice (including a history of previous pregnancy), hepatic porphyria, leiomyoma, hypercalcemia associated with bone metastases of breast cancer. For the treatment of breast and prostate cancer only: diseases of the coronary or cerebral vessels, active thrombophlebitis or thromboembolic diseases (high doses of estrogens used for treatment increase the risk of myocardial infarction, pulmonary embolism, thrombophlebitis).
Side effects: In women: pain, sensitivity and enlargement of the mammary glands, amenorrhea, breakthrough bleeding, menorrhagia, intermenstrual “spotting” vaginal discharge, swelling of the mammary glands, increased libido. In men, pain and sensitivity of the mammary glands, gynecomastia, decreased libido. Peripheral edema, gallbladder obstruction, hepatitis, pancreatitis. Intestinal or biliary colic, flatulence, anorexia, nausea, diarrhea, dizziness, headache (including migraine), intolerance to contact lenses, vomiting (mainly of central origin, mainly when prescribing large doses). In the treatment of breast and prostate cancer (additionally): thromboembolism, thrombosis.
Pharmacodynamics: Estrogen is a derivative of stilbene; its estrogenic activity is equivalent to estrone (a natural follicular hormone necessary for the normal development of the female body). Together with the corpus luteum hormone, follicular hormone is involved in the regulation of the menstrual cycle. Estrogens, interacting with specific receptors, affect target organs. Under their influence, epithelial proliferation occurs in the fallopian tubes, cervix, vagina, external genitalia, and excretory ducts of the mammary glands. Increases the sensitivity of the muscles of the uterus and fallopian tubes to drugs that stimulate their motor skills. It has a hypolipidemic effect, increases the level of alpha-lipoproteins in the blood and sensitivity to the action of insulin, improves glucose utilization. In large doses, estrogens retain water and Na+ in the body and inhibit erythropoiesis. In large doses it inhibits, and in small doses it activates the secretion of FSH. Circulation in the blood of large quantities of estrogens for a short time promotes the ovulatory type of LH production. Hexestrol facilitates the course of pathological menopause in women, prevents the development of postmenopausal osteoporosis, and eliminates common disorders that arise in the body of women due to ovarian hypofunction after gynecological operations.
Pharmacokinetics: Absorption is high, has a “first pass” effect through the liver. It is excreted by the kidneys; depending on the physiological state (pregnancy, individual phases of the ovarian-menstrual cycle), age and other conditions, the rate of excretion may be different.
Interaction: Antiestrogenic drugs (clomiphene, etc.), used to treat infertility, can block estrogen receptors and weaken the effect of estrogens. Folic acid and thyroid medications enhance the effect of hexestrol. Hexestrol increases the effectiveness of lipid-lowering and antiarrhythmic drugs, weakens the effects of male sex hormones, diuretics and anticoagulants.
Drug registration number: P No. 002087/01-2003
Date of registration (re-registration) of the drug: 01/13/2003
Instructions for use
Most often the drug is used to treat cattle. It is necessary to follow certain rules for using the drug for cows. The instructions say the following:
- Warmed hexestrol is administered to cows (0.25−2.5 mg);
- If ovarian hypofunction is indicated, the medicine should be administered 2 times, 1-3 ml each, for 5-10 days. After this period, the animal’s menstrual cycles should improve;
- In case of slow development of the uterus after childbirth, Sinestrol is administered 2 times, 2-5 ml per 24 hours;
- They are treated with Sinestrol for 45 days to normalize the functioning of the mammary glands in cows;
Sexual diseases in horses are treated like in cows. It should be remembered that you always need to calculate the weight of the animal and the injection dose for it.
Experts do not recommend using the drug in conjunction with medications that treat the thyroid gland, and also not mixing it with hormones and similar analogues.
Doctors prohibit the use of the medicine for those animals that suffer from chronic liver and kidney diseases, as well as during pregnancy and lactation. In other cases, veterinarians advise using the medicine in dosages that correspond to the instructions for use of Sinestrol for animals.
With prolonged use, it can cause the formation of cysts and ovarian hypoplasia. Doctors have not established any negative effects after the first and last injection.
Indications and contraindications for use
Sinestrol for pigs, cows and other farm animals is used only as prescribed by a veterinarian. The hormonal drug is intended for the complex treatment of various disorders and diseases of the genital area.
Main indications for use of Sinestrol:
- acute and chronic endometritis;
- normalization of breast function;
- pyometra;
- removal of placenta and mummified fruits;
- stimulation of hunting in healthy females.
Sinestrol is prescribed to animals with ovarian hypofunction, uterine subinvolution, and also with incomplete dilatation of the uterine cervix.
Sinestrol has several contraindications for use, which must be taken into account in order not to harm the animal. The hormonal drug is prohibited for kidney and liver diseases, individual intolerance. Also, Sinestrol is not prescribed to sick, weakened animals and females during pregnancy.
Safety and storage rules
When using the medicine, do not forget about the rules of hygiene:
- After administering the drug, you must wash your hands thoroughly with soap;
- The drug should not come into contact with the cavity and mucous membrane of the eye; if this happens, you should immediately rinse your eyes with plenty of water;
- The bottles that contained the medicine must be disposed of. They are not intended for further use;
- There is no antidote for the medicine. In special cases, general therapy and monitoring of vital human organs are carried out.
The drug should be stored in a dry, dark place. It should not be accessible to children. Cannot be placed with food. If all conditions are met, Sinestrol can be stored in them for up to 5 years. At the end of this period, it is necessary to dispose of the medicine , observing the rules and laws.
This medicine can cure an animal. But before you start, it would be better to contact specialists. They know exactly how to correctly follow the instructions for using Sinestrol in veterinary medicine. If the animal’s disease progresses, you should contact your local doctor.
