Clinical use of Egipres in patients with impaired carbohydrate metabolism and cardiovascular diseases: what is the advantage?

Interaction

Amlodipine

It can be expected that inhibitors of liver microsomal oxidation enzymes (erythromycin in young people, diltiazem in elderly people, ketoconazole, itraconazole, ritonavir) will increase the concentration of amlodipine in the blood plasma, increasing the risk of side effects, and inducers of liver microsomal oxidation enzymes will decrease it. With simultaneous use of amlodipine with cimetidine, the pharmacokinetics of amlodipine does not change.

A simultaneous single dose of 240 ml of grapefruit juice and 10 mg of amlodipine orally is not accompanied by a significant change in the pharmacokinetics of amlodipine. Unlike other CCBs, no clinically significant interaction was found with amlodipine (III generation CCB) when used together with NSAIDs, especially indomethacin.

It is possible to enhance the antianginal and antihypertensive effect of CCBs when used together with thiazide and loop diuretics, verapamil, ACE inhibitors, beta-blockers and nitrates, as well as increase their antihypertensive effect when used together with a

Description of the dosage form

Capsules 5 mg + 5 mg: hard gelatin CONI-SNAP 3, self-closing, with a light burgundy base and cap.

Capsules 5 mg + 10 mg: hard gelatin CONI-SNAP 0, self-closing, with a light pink base and a light burgundy cap.

Capsules 10 mg + 5 mg: hard gelatin CONI-SNAP 0, self-closing, with a light pink base and a dark burgundy cap.

Capsules 10 mg+10 mg: CONI-SNAP 0 hard gelatin capsules, self-closing, with a dark burgundy base and cap.

Capsule contents: a mixture of granules and powders of white or almost white color, odorless or almost odorless.

Analogs

Level 4 ATC code matches:
Actaparoxetine

Plizil

Fluxen

Paroxin

Surlift

Asentra

Elycea

Fluoxetine

Lenuksin

Escitalopram

Selectra

Stimuloton

Citalopram

Cipramil

Zoloft

Paroxetine

Prozac

Paxil

Rexetine

Fevarin

Paxil , Apo-paroxetine , Paroxetine , Plizil , Actaparoxetine , Rexetine , Sirestill .

Compound

Use during pregnancy and breastfeeding

The drug is contraindicated for use, because ramipril may have an adverse effect on the fetus - impaired development of the fetal kidneys, decreased blood pressure in the fetus and newborns, impaired renal function, hyperkalemia, hypoplasia of the skull bones, oligohydramnios, contracture of the limbs, deformation of the skull bones, pulmonary hypoplasia. Before starting to take the drug in women of childbearing age, pregnancy should be excluded.

If a woman is planning a pregnancy, treatment with the drug should be discontinued. If pregnancy occurs during treatment with the drug, you should stop taking it as soon as possible and transfer the patient to take other drugs, the use of which will have the least risk for the child.

If treatment with the drug is necessary during breastfeeding, it should be discontinued (there are no data on the excretion of amlodipine and ramipril in women's breast milk).

Fertility

Amlodipine. Some patients receiving CCBs experienced reversible biochemical changes in the sperm heads. Clinical data are insufficient to assess the potential effect of amlodipine on fertility.

Side effects of Adepress

Most common:

• drowsiness or insomnia , tremor , dizziness , asthenic syndrome , anxiety;
• orthostatic hypotension;
• decreased appetite, nausea, vomiting, constipation or diarrhea , dry mouth;
• frequent urination;
• ejaculation disorders and libido disorders.

Rare side effects:

• confusion, paresthesia , hallucinations, extrapyramidal disorders;
• myasthenia gravis , arthralgia , myalgia ;
• hepatitis;
• urinary retention;
• galactorrhea, anorgasmia ;
• rash, urticaria, itching, angioedema ;
• seizures, serotonin syndrome, panic disorders;
• dilated pupils, blurred vision.