Nemozol tablets and suspension: instructions for use, price, reviews from doctors for children

Compound

Nemozol tablets in p/o contain 0.4 g of albendazole , corn starch, povidone-30, purified talc, sodium lauryl sulfate, gelatin, silicon dioxide (in colloidal form), sodium starch glycolate, methyl and propyl paraben, magnesium stearate.
Composition p/o: titanium dioxide, hydroxypropyl methylcellulose, propylene glycol; methylene chloride and isopropanol (evaporate when dried). Nemozol chewable tablets contain 0.4 g of albendazole , corn starch, povidone-30, purified talc, sodium lauryl sulfate, silicon dioxide (in colloidal form), gelatin, citric acid, methyl and propyl paraben, sodium starch glycolate, aspartame, magnesium stearate, flavorings (pineapple/mint).

The Nemozol suspension albendazole at a concentration of 20 mg/ml. Auxiliary components: MCC, sodium carboxymethylcellulose, sorbitol , benzoic and sorbic acids, glycerin (glycerol), potassium hydrochloride, polysorbate-80, flavorings (ice cream essences/mixed fruit flavor), purified water.

Pharmacodynamics and pharmacokinetics

Albendazole contained in Nemozole is an antiparasitic agent .

The main mechanism of action of the substance is associated with its ability to inhibit the polymerization of the beta-tubulin protein.

This leads to the fact that the activity of the cytoplasmic microtubular system in the cells of the intestinal tract of helminths is disrupted; the course of biochemical processes in the organisms of parasites changes; in the muscle cells of nematodes, the movement of secretory granules and other organelles is blocked.

The result of such exposure is the death of parasites.

It is most effective against the larvae of tapeworms (pork tapeworm and echinococcus), as well as against the roundworms Strongyloides stercolatis (intestinal eel).

Pharmacokinetics

The substance is poorly absorbed from the digestive tract and is not found in the plasma unchanged. Characterized by low bioavailability (approximately 30%).

An increase in absorption and Cmax (5 times) is facilitated by taking the drug simultaneously with fatty foods.

The substance quickly undergoes biotransformation in the liver. The primary metabolite (M1) is albendazole sulfoxide, which also has anthelmintic activity .

TCmax M1 varies from 2 to 5 hours. About 70% of albendazole sulfoxide is bound to plasma proteins. The substance is almost completely distributed throughout the body; determined in the liver, bile, urine, cystic fluid and cyst wall, cerebrospinal fluid.

In the liver, M1 is converted to albendazole sulfone (M2) and other oxidized products. T1/2 M1 - from 8 to 12 hours. Excreted by the kidneys in the form of various metabolic products.

If renal function is impaired, the excretion of albendazole and M1 does not change.

With impaired liver function, the bioavailability of the substance and Cmax M1 increase (2 times), and T1/2 also lengthens.

Albendazole increases the activity of microsomal enzymes of the CYP system; accelerates the metabolism of many drugs.

Pharmacological properties of the drug Nemozol™

Pharmacodynamics. Albendazole is a broad-spectrum anthelmintic agent that is also active against pathogenic protozoa. Acts on intestinal and tissue forms of parasites; active against eggs, larvae and adult helminths. The antihelminthic effect of the drug is due to inhibition of tubulin polymerization, which leads to metabolic disturbances and death of the helminth. Albendazole is active against intestinal parasites, including nematodes (Ascaris lumbricoides, Triсhiurus triсhiura, Enterobius vermicularis, Ancylostoma duodenale, Necator americanus, Strongiloides stercoralis, Cutaneous Larva Migrans) , cestodes (Hymenolepsis nana, Taenia solium, Taenia saginata) , trematodes ( Opisthorhis viverrini, Clonorchis sinensis) , protozoa ( Giardia lamblia (intestinalis and duodenalis) . Albendazole is effective against tissue parasites, including cystic echinococcosis and alveolar echinococcosis, caused by invasion of Echinococcus granulosus and Echinococcus multilocularis , respectively. The drug is also effective in the treatment of neurocysticercosis, caused by nogo invasion larvae of the pork tapeworm T. solium, capillariasis caused by invasion of Gnatostoma spinigerum . Albendazole destroys cysts or significantly reduces their size in patients with cysts of granular echinococcus. Pharmacokinetics. After oral administration, the drug is poorly absorbed (up to 5%) in the gastrointestinal tract. Simultaneous use of fatty foods approx. increases drug absorption 5 times. Albendazole is 70% bound to blood plasma proteins and is freely distributed in the body; determined in urine, bile, liver, cyst wall and cyst fluid, CSF. Albendazole sulfoxide is rapidly converted in the liver to albendazole sulfone (a secondary metabolite) and other oxidized products. The half-life of albendazole sulfoxide from blood plasma lasts 8–12 hours. Albendazole sulfoxide and other metabolites are excreted primarily in the bile, and only a small amount is excreted in the urine. Since the renal excretion of albendazole and its primary metabolite, albendazole sulfoxide, is insignificant, clearance in patients with impaired renal function does not change. In patients with biliary obstruction, systemic bioavailability may be increased and the half-life of albendazole sulfoxide may be prolonged.

Indications for use

The drug is used to treat:

nematodes ( hookworm , ascariasis , trichuriasis , necatoriasis , enterobiasis );
strongyloidiasis;
toxocariasis;
giardiasis;
neurocysticercosis , the causative agent of which is the larvae of the armed (pork) tapeworm;
echinococcosis of the peritoneum , lungs and liver, the causative agent of which is the larvae of the tapeworm echinococcus;
mixed helminthic infestations.

It is also advisable to use the drug as an addition to the main treatment during surgical interventions to remove echinococcal cysts.

Side effects

Side effects of the drug may manifest themselves as:

liver dysfunction , in which there is an increase (weak/moderate)
transaminase activity;
nausea/vomiting;
pain in the abdomen;
inhibition of bone marrow hematopoiesis ( agranulocytosis , leukopenia , pancytopenia , granulocytopenia , thrombocytopenia );
dizziness;
headache;
clinical signs of irritation of the meninges ( meningeal symptoms ).
alopecia (reversible);
skin rash;
itching;
hyperthermia;
increased blood pressure;
hypersensitivity reactions;
acute renal failure.

Side effects of the drug Nemozol™

from the gastrointestinal tract: stomatitis, dry mouth, heartburn, nausea, vomiting, abdominal pain, flatulence, diarrhea, constipation; from the cardiovascular system: arterial hypertension; from the central and peripheral nervous system: insomnia or drowsiness, headache, dizziness, confusion, disorientation, hallucinations, convulsions, decreased visual acuity; from the hematopoietic system: leukopenia, thrombocytopenia, pancytopenia; from the skin and its appendages: alopecia; from the urinary system: impaired renal function, acute renal failure; allergic reactions: itching, urticaria, pemphigus, dermatitis, chills; laboratory indicators: increased activity of liver enzymes.

Instructions for use of Nemozol (Method and dosage)

Nemozol suspension, instructions for use

The medicine is taken orally with meals. To increase the bioavailability of albendazole, it should be taken with a fatty meal.

Nemozol for children 12-24 months with ascariasis, hookworm, trichinosis , enterobiasis, necatoriasis, a one-time dose of 1 dessert spoon of suspension (10 ml) is indicated.

Recommendations on how to take medicine for children over two years of age are as follows:

for ascariasis , hookworm , trichinosis , enterobiasis , necatoriasis - the child is given 20 ml of the drug once (it is recommended to take Nemozol for worms at the same time for all persons living together).
For taeniasis and strongyloidiasis , the suspension for children is given 1 r./day, 20 ml for 3 days.
For toxocariasis , it is recommended to take 20 ml of suspension once a day for 10 days.
For polyhelminthiases caused by infection of the body with Clonorchis sinensis (Chinese fluke) and Opisthorchis viverrini (Civet fluke), patients are recommended to be given 20 ml of suspension twice a day for 3 days.

Treatment of giardiasis in children aged 2 to 12 years is carried out using a dose of 20 ml/day. (the medicine is taken in one dose). The course lasts 5 days.

For adult patients, Nemozol for giardiasis, ascariasis, hookworm disease, strongyloidiasis, trichinosis, enterobiasis, necatoriasis, toxocariasis, taeniasis and polyhelminthiasis is prescribed to be taken according to a similar scheme.

For cystic/alveolar echinococcosis , as well as for neurocysticercosis , patients weighing more than 60 kg are given the drug twice a day, 20 ml. For patients weighing less than 60 kg, the recommended daily dose of albendazole is 15 mg/kg, divided into 2 doses. The highest dose is 800 mg/day.

The course of treatment for cystic echinococcosis is designed for 28 days. After 14 days, treatment can be repeated. If necessary, 3 courses are allowed.

For alveolar echinococcosis, the patient is prescribed Nemozol for 3 courses of 28 days with 14-day intervals between courses.

For neurocysticercosis, treatment lasts from 1 week to 30 days. A repeat course is possible after 14 days.

For a creeping rash, take the suspension 20 ml once a day for 1-3 days.

Nemozol tablets, instructions for use

The tablets are taken orally with food (preferably fatty foods, as this increases the bioavailability of albendazole ).

For children over three years of age, adolescents and adults, the instructions provide the following recommendations on how to take the drug:

for ascariasis, hookworm, trichinosis, enterobiasis, necatoriasis - 1 tablet/day. one-time use.
For taeniasis and strongyloidiasis, tablets are given one tablet per day for 3 days.
For toxocariasis, take one tablet once a day for 10 days.
For mixed helminthiases caused by infection of the body with Clonorchis sinensis (Chinese fluke) and Opisthorchis viverrini (Civet fluke), patients are recommended to take one tablet twice a day for 3 days.

For the treatment of giardiasis in adults and children over 3 years of age, the patient is given 1 Nemozol tablet per day for 5 days.

For cystic/alveolar echinococcosis , as well as for neurocysticercosis , patients weighing more than 60 kg are given the drug twice a day, 1 tablet. For patients weighing less than 60 kg, the recommended daily dose of albendazole is 15 mg/kg, divided into 2 doses. The highest dose is 800 mg/day.

The course of treatment for cystic echinococcosis is designed for 28 days. After 14 days, treatment can be repeated. If necessary, 3 courses are allowed.

For alveolar echinococcosis, the patient is prescribed Nemozol for 3 courses of 28 days with 14-day intervals between courses.

For neurocysticercosis, treatment lasts from 1 week to 30 days. A repeat course is possible after 14 days.

For a creeping rash, take one tablet per day for 1-3 days.

It should be remembered that it is recommended that all people living together take anti-worm tablets at the same time.

How quickly does Nemozol work?

Reviews of Nemozole for children and adults indicate that parasites usually go away within a week after taking the drug. 3 weeks after treatment, it is recommended to do a repeat stool test.

Nemozole®

Inside, during or after meals. The tablet should be chewed.

No special preparation or diet is required.

The dosage form is chosen individually, depending on the convenience of taking the drug and the tolerability of its constituent substances.

The dose of the drug is set individually, depending on the type of invasion and the patient’s body weight.

The maximum daily dose is 800 mg.

In children, long-term use of high doses of albendazole should be avoided if possible.

For nematodes (including ascariasis, trichuriasis, necatoriasis)

The standard dose for the treatment of roundworm infestation for adults and children weighing 60 kg or more is 400 mg per day once;

for adults and children weighing less than 60 kg - 15 mg/kg body weight once or in 2 doses.

For enterobiasis

adults and children over 3 years of age take the drug at a dose of 400 mg once. If necessary, after 14 days, repeat the course of treatment at the same dose and in the same regimen.

For strongyloidiasis

,
hookworm,
adults and children over 3 years of age take the drug in a dose of 400 mg once for 3 days. If necessary, after 7 days the course of treatment is repeated in the same doses.

For trichinosis

The drug is taken 400 mg 2 times a day for 10-14 days. In case of severe invasion and organ damage (myocarditis, pneumonitis, meningoencephalitis), glucocorticosteroid and symptomatic drugs are also taken.

For toxocariasis

adults and children over 14 years of age and with a body weight of more than 60 kg take the drug 400 mg 2 times a day for 10 days, and with a body weight of less than 60 kg, 200 mg. Repeated courses of treatment are required at intervals of 2 weeks/month. During treatment, it is necessary to monitor peripheral blood (once every 5-7 days) and aminotransferases at the same time.

For giardiasis

: 400 mg 1 time per day for 3 days. Children weighing less than 10 kg - 200 mg once a day once for 5 days.

For mixed invasions

The drug is taken 400 mg 2 times a day for 3 days. If necessary, the course of treatment can be repeated after 1 month.

For neurocysticercosis and hydatid echinococcosis

patients with a body weight of 60 kg or more take 400 mg 2 times a day, with a body weight of less than 60 kg - at the rate of 15 mg / kg body weight per day in 2 divided doses; maximum daily dose 800 mg. The course of treatment for neurocysticercosis is 28-30 days (2 days before taking the drug and in the first week of taking glucocorticosteroid drugs), for echinococcosis 3 cycles of 28 days with a 14-day break between cycles.

Before using the drug, a clinical blood test and biochemical blood test are required. Treatment is carried out with normal laboratory values. During treatment, blood and aminotransferase tests are performed every 5-7 days.

If leukocytes decrease below 3.0×109 and aminotransferase activity increases 2-fold, it is necessary to suspend treatment until the parameters normalize.

Therapy with the drug can be resumed after laboratory values return to the level that was before the start of therapy, however, laboratory tests should be performed regularly during therapy.

The prescription of hepatoprotectors during treatment and in cases of toxic manifestations is ineffective; discontinuation of the drug is necessary.

Treatment with albendazole of alveolar

echinococcosis is an additional remedy.

The dosage and regimen of the drug are the same. as with hydatid echinococcosis. The duration and course of treatment is determined by the patient's condition and tolerability of the drug.

special instructions

During treatment with the drug, it is necessary to monitor changes in the cellular composition of the blood (the level of leukocytes is checked before starting treatment and then every 2 weeks of the cycle) and the activity of liver enzymes.

If the patient experiences leukopenia , treatment should be suspended. You can continue the course only if the degree of decrease in the concentration of neutrophils and leukocytes is insignificant, and leukopenia does not progress.

If the activity of liver enzymes exceeds the upper limit of normal by more than twice, the use of Nemozol is discontinued until they are completely normalized.

For neurocysticercosis, the drug is prescribed in combination with anticonvulsants and corticosteroids. Oral and parenteral forms of GCS in the first week of using Nemozol are used to prevent an attack of hypertension .

Special instructions for the use of Nemozol™

During use of the drug, it is necessary to monitor the activity of liver enzymes before the start of each treatment cycle. If the indicators exceed the upper limit of normal by more than 2 times, the use of Nemozol must be stopped until the indicators are completely normalized. It is necessary to monitor the number of leukocytes at the beginning and every 2 weeks of the 28-day cycle of drug use. The use of Nemozol for leukopenia can be continued if the degree of reduction is insignificant and the leukopenia does not progress. Patients with neurocysticercosis should receive appropriate therapy with steroids and anticonvulsants. Special security measures. In order to prevent the use of Nemozol in the early stages of an unknown pregnancy, women of childbearing age can begin taking the drug only after receiving a negative pregnancy test result or at the beginning of menstruation. During the treatment period, with breaks between courses inclusive, it is necessary to ensure reliable contraception. Use during pregnancy or breastfeeding. Taking Nemozol during pregnancy is contraindicated. During treatment, breastfeeding should be stopped (the safety of the drug has not been established). Children. The drug is used in children over 2 years of age. Influence on reaction speed when driving vehicles or working with other mechanisms. During the treatment period, you should refrain from driving vehicles and performing work that requires increased attention and quick reaction.

Nemozol's analogs

Level 4 ATC code matches:
Medamin

Vermakar

Vermox

Aldazole

Zentel

Wormil

Vormin

Sanoxal

Mebendazole

Structural analogues of Nemozol: Gelmodol-VM , Sanoxal , Albendazole .

Nemozol or Vermox - which is better?

Vermox is a broad-spectrum antiparasitic agent. The basis of the drug is the substance mebendazole , its concentration in one tablet is 100 mg.

Vermox is most effective against trichuriasis and enterobiasis . Nemozol exhibits the greatest activity against the larvae of pork tapeworm and echinococcus , as well as against intestinal acne .

Vermox can be used from the age of two, while the Nemozol suspension is prescribed to children from the age of one.

Which is better: Dekaris or Nemozol?

Decaris tablets levamisole (50 or 150 mg/tablet) as an active substance Levamisole is effective against infections with the following parasites:

Ancylostoma duodenale;
Ascaris lumbrocoides;
Necator Americanus.

The drug is approved for use in patients over three years of age.

Nemozol chewable tablets 400 mg No. 1

A country

India
Country of manufacture may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Active substance

Albendazole

Compound

The active substance is albendazole.

pharmachologic effect

The main mechanism of action of albendazole is its inhibitory effect on betatubulin polymerization, which leads to the destruction of cytoplasmic microtubules of helminth intestinal tract cells: it changes the course of biochemical processes (suppresses glucose utilization), blocks the movement of secretory granules and other organelles in the muscle cells of roundworms, causing their death. It most effectively affects the larval forms of cestodes - Echinococcus granulosus and Taenia solium, nematodes - Strongyloides stercolatis. Pharmacokinetics: Poorly absorbed in the gastrointestinal tract; unchanged form is not detected in blood plasma, because quickly turns into the primary metabolite in the liver - albendazole sulfoxide, which also has anthelmintic activity. Bioavailability when taken orally is low, about 30%. Eating fatty foods increases absorption and maximum concentration (5 times). The maximum concentration of albendazole sulfoxide is reached after 2-5 hours, 70% bound to plasma proteins, and almost completely distributed throughout the body; found in urine, bile, liver, in the wall of the cyst and cystic fluid, cerebrospinal fluid. Albendazole sulfoxide in the liver is converted into albendazole sulfone (secondary metabolite) and other oxidized products. The half-life of albendazole sulfoxide is 8-12 hours. It is excreted in the form of various metabolites in the urine. Renal excretion of albendazole and its main metabolite, albendazole sulfoxide, is insignificant; clearance does not change in patients with impaired renal function. Against the background of liver damage, bioavailability increases, maximum the concentration of albendazole sulfonide increases 2 times, the half-life is extended. Albendazole is an inducer of microsomal enzymes of the cytochrome P-450 system: it accelerates the metabolism of many drugs.

Indications for use

Nematodes (ascariasis, enterobiasis, hookworm disease, necatoriasis, trichocephalosis, etc.). Mixed helminthic infestations. Strogyloidosis, neurocysticercosis caused by the larval form of the pork tapeworm (Taenia solium); echinococcosis of the liver, lungs, peritoneum, caused by the larval form of the canine tapeworm (Echinococcus granulosus). As an adjuvant in the surgical treatment of echonococcal cysts. Giardiasis and toxocariasis.

Mode of application

The drug is taken orally during meals. It is recommended to treat all family members simultaneously. The standard dosage for the treatment of roundworm infestation for adults and children over 2 years of age is 400 mg or 20 ml of suspension orally once; neurocysticercosis and echinococcosis: patients weighing 60 kg or more - 400 mg 2 times a day, less than 60 kg - 15 mg/kg per day in 2 divided doses; maximum daily dose - 800 mg; course of treatment: for neurocysticercosis - 8-30 days, for echinococcosis - 3 cycles of 28 days with a 14-day break between cycles. For giardiasis in children, 10-15 mg/kg once a day for 5-7 days. For toxocariasis - adults and children over 14 years of age, weight more than 60 kg - 400 mg 2 times a day for 7-14 days, less than 60 kg - 200 mg 2 times a day for 7-14 days, for children - 10 mg/kg 2 times a day 7 -14 days.

Interaction

Dexamethasone and cimetidine increase the concentration of albendazole sulfoxide in the blood.

Side effect

Impaired liver function with changes in liver function tests (weak or moderate increase in transaminase levels), inhibition of bone marrow hematopoiesis (leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia), fever, abdominal pain, nausea, vomiting, headache, dizziness, meningeal symptoms, increased blood pressure, acute renal failure, reversible alopecia, skin rash, itching and other allergic reactions.

Contraindications

Individual intolerance (including to other benzimidazole derivatives), damage to the retina, pregnancy.

Overdose

Treatment; symptomatic, gastric lavage, activated carbon.

special instructions

Use with caution in cases of hematopoietic disorders, liver dysfunction (before and during treatment, its functions are regularly monitored), breastfeeding. In women of childbearing age, a pregnancy test is performed before starting treatment. Reliable contraception is required during therapy. Patients with neurocystocircosis should receive appropriate therapy with steroids and anticonvulsants. Oral or intravenous corticosteroids are used to prevent a hypertensive attack during the first week of anticyst therapy. Blood tests should be performed at the beginning of each 28-day cycle and every 2 weeks during albendazole therapy. It is possible to continue treatment with albendazole if the decrease in total leukocytes and neurotrophil leukocytes is moderate and does not progress.

Dispensing conditions in pharmacies

On prescription

Reviews of Nemozole

Reviews from doctors about the drug Nemozol allow us to conclude that this medicine for worms is one of the best today. The drug disrupts the flow of biochemical processes in the body of parasites, causes destruction of their cell membranes and, as a result, leads to the death of helminths.

The effect of the drug applies to tapeworm larvae (armed, canine), Giardia, whipworm, pinworms, opisthorchia, roundworm, necator americanus, intestinal eels, microsporidia, toxocara. Nemozol is also effective for polyhelminthiasis.

The manufacturer produces it in the form of tablets and suspensions: tablets are the optimal dosage form for adults, a suspension is prescribed for children over 12 months of age.

Most people leave good reviews about Nemozole on forums. Since helminthic infestations most often occur in childhood, these are mainly reviews of Nemozol for children. Almost all mothers note the speed of the drug and its effectiveness, however, they emphasize that some patients may experience side effects.

Nemozol suspension bottle 100mg/5ml 20ml for oral administration

A country

India
Country of manufacture may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Active substance

Albendazole

Compound

The active substance is albendazole.

pharmachologic effect

Indications for use

Mode of application

Interaction

Dexamethasone and cimetidine increase the concentration of albendazole sulfoxide in the blood.

Side effect

Contraindications

Individual intolerance (including to other benzimidazole derivatives), damage to the retina, pregnancy.

Overdose

Treatment; symptomatic, gastric lavage, activated carbon.

special instructions

Dispensing conditions in pharmacies

On prescription

Nemozol price

The price for Nemozol tablets in Russian pharmacies varies from 176 to 206 rubles. The cost of chewable tablets 400 mg is 200-210 rubles. The price of Nemozol suspension is 160-205 rubles.

The average price in Ukraine for Nemozol (albendazole) in the form of tablets in p/o is 200 UAH, chewable tablets are 250 UAH. You can buy a suspension for oral administration for 220 UAH.

Online pharmacies in RussiaRussia
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Nemozol tablets p.p.o.
400 mg 1 piece Ipca Laboratories Ltd RUB 198 order
Nemozol chewable tablets. 400 mg 1 piece Ipca Laboratories Ltd
RUB 198 order
Nemozol susp. for internal approx. 100mg/5ml 20mlIpca Laboratories Ltd
RUB 211 order
Nemozol tablets p.p.o. 400 mg 5 pcs. Ipka Laboratories Limited
RUB 804 order
Cream Nemozol 15 mlLaboratoriya Emansi/Proba LLC
140 rub. order

Pharmacy Dialogue

Nemozol tablets 400 mg No. 1Ipka Laboratoris
200 rub. order
Nemozol suspension bottle 100mg/5ml 20ml for oral administrationIpka Laboratoris
RUB 197 order
Nemozol tablets 400 mg No. 5Ipka Laboratoris
RUR 777 order
Nemozol chewable tablets 400 mg No. 1Ipka Laboratoris
185 rub. order
Nemozol (15g) Emansi Laboratory JSC
RUB 173 order