Indications for use
Therapy and prevention of diseases caused by Klebsiella ozaenae, pneumoniae and rhinoscleromatis as part of multicomponent treatment:
- lesions of the digestive tract ( gastroenterocolitis, pancreatitis, cholecystitis, intestinal dysbiosis );
- ozena, scleroma;
- diseases of young children and newborns of an inflammatory nature ( intestinal dysbiosis, gastroenterocolitis, pemphigus, omphalitis, septicemia, pyoderma, septicopyemia );
- surgical diseases (purulent skin diseases, wound suppuration, peritonitis , burns , pleurisy , osteomyelitis, mastitis, abscess );
- urogenital infections ( pyelonephritis, cystitis, urethritis, vulvitis, colpitis, endometritis, bartholinitis, salpingoophoritis );
- diseases of the ear, nose, throat, pharynx, oral cavity, bronchi, larynx, lungs, pleura of a purulent-inflammatory nature (sore throat , otitis, laryngitis, pharyngitis, periodontitis, stomatitis, frontal sinusitis, sinusitis, pneumonia, bronchitis, pleurisy );
- conjunctivitis of post-traumatic origin, corneal ulcer, keratoconjunctivitis , iridocyclitis ;
- prevention of hospital infections associated with Klebsiella .
Klebsiella bacteriophage polyvalent purified liquid
Trade name: Bacteriophage Klebsiellae polivalental purified fluid International name: Bacteriophage Klebsiellae
Release form: solution for local use and oral administration (bottles) 10, 20 ml
Ingredients: Klebsiella bacteriophage
Pharmacological group: MIBP-bacteriophage
Pharmacological group according to ATK: V03A (Other therapeutic products)
Description: The drug contains bacteriophages that are active against 89 - 93% of clinical strains of bacteria Klebsiella pneumoniae, ozena, scleroma. In terms of the spectrum of antibacterial activity, the drug is superior to antibiotics of the streptomycin, aminoglycoside, tetracycline and macrolide genera, and is active against antibiotic-resistant strains. The drug is purified from proteins and bacterial antigens, the degree of purification is 98.4 - 99.7%. The drug is harmless, non-reactogenic, in therapeutic doses and doses exceeding the therapeutic dose by 3500 times. The drug does not cause allergic or other adverse reactions, has no contraindications for use, unlike antibiotics, when administered orally it does not disturb the intestinal biocenosis and therefore can be used in newborns and children of the first year of life.
Indications: Klebsiella polyvalent bacteriophage is intended for the treatment of ozena, scleroma, as well as other purulent-septic and enteral diseases caused by the bacteria Klebsiella pneumonia, ozena and rhinoscleroma. 1. Diseases of the ear, throat, nose, respiratory tract and lungs - ozena, scleroma, inflammation of the sinuses, middle ear, tonsillitis, pharyngitis, laryngitis, bronchitis, pneumonia, pleurisy. 2. Surgical infections - wound suppuration, burns, abscesses, phlegmon, mastitis, osteomyelitis, peritonitis. 3. Urogenital infectious pathology - urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingo-oophoritis. 4. Enteral infections - gastroenterocolitis, cholecystitis, intestinal dysbiosis. 5. Generalized septic diseases. 6. Purulent-septic diseases of newborns - omphalitis, pemphigus, gastroenterocolitis, sepsis.
Dosage regimen: In the treatment of ozena and scleroma, the drug is used for irrigation of the nasal cavity, nasopharynx, and administration into the sinuses. In the treatment of diseases of the respiratory tract and lungs, the drug is used in the form of aerosols, and the oral route of administration is also used. In the treatment of other diseases, the drug is used locally in the form of irrigations, lotions, and also for administration into cavities - wounds, abscesses, abdominal, pleural, bladder, uterus, sinuses, middle ear. In addition, the drug is used orally and in the form of high enemas in the treatment of gastroenterocolitis, cholecystitis, pyelonephritis, cystitis, urethritis, mastitis, and generalized septic diseases. The therapeutic dose of the drug is 0.3 - 3.0 ml per 1 kg of body weight. The drug is used 1 - 3 times a day for 7 - 20 days; in the treatment of ozena and scleroma, treatment courses are 30 - 40 days. Repeated courses are possible.
Contraindications: Hypersensitivity.
Side effects: Not described.
Pharmacodynamics: The antibacterial effect provided by the drug is due to the specific lysis of pathogenic bacteria in the inflammation site under the influence of bacteriophages. Regardless of the method of administration of the drug, bacteriophages penetrate the blood and lymph, enter the site of inflammation and are excreted by the kidneys, providing a sanitizing effect on the urinary tract. In addition, the drug has a stimulating effect on the patient’s immune system and is effective in the treatment of purulent-septic diseases accompanied by immunosuppressive conditions, which is generally typical for diseases caused by opportunistic microflora, and in particular for chronic and acute klebsiosis - ozena and scleroma.
Shelf life: 1 year.
Drug registration number: 91/175/14
special instructions
Before use, the bottle with the drug must be shaken and its transparency and the presence of sediment assessed. If turbidity or sediment is detected, the drug should not be used!
Due to the presence in the drug of a favorable climate for the development of microorganisms from the environment that cause turbidity of the solution, opening the bottle should be done according to the rules indicated below:
- hands must be washed thoroughly;
- Before removing, the cap must be treated with an alcohol solution;
- the cap should be removed without removing the stopper;
- the drug should be removed from an opened container only by piercing the stopper with a sterile syringe;
- if during opening the cap was accidentally uncorked along with the cap, then it should not be placed with the inner surface on the table, and the bottle should not be left open (after taking the product, it must be closed with the cork);
- The opened bottle should be stored in the refrigerator.
If these rules are followed and there is no turbidity, the product from the opened bottle can be used throughout the entire shelf life.
Bacteriophage Klebsiella polyvalent purified 20ml N4 (Microgen)
The drug is used for oral administration (orally), in the form of enemas, applications, irrigations, injection into wound cavities, vagina, uterus, nose, sinuses, as well as into drained cavities: abscesses, abdominal, pleural, bladder, renal pelvis. The drug is taken orally on an empty stomach 0.5-1 hour before meals. Patient's age Dose for 1 dose for various methods of administering the drug orally (ml) in enema (ml) 0-6 months 5106-12 months 1020 From 1 year to 3 years 1520-30 From 3 to 8 years 2030 -40 From 8 years and older 20-3040-50 Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug orally. In the case of treating the cavity of a purulent lesion with chemical antiseptics, before using the bacteriophage, it should be washed with a sterile 0.9% solution sodium chloride. In the treatment of ozena and scleroma, the drug is used for washing the nasal cavity and mucous membrane of the upper respiratory tract, for administration into the sinuses (according to clinical indications), as well as for damage to the pharynx, larynx, trachea in the form of inhalations (without heating and use ultrasound). The dose of the drug for treating the mucous membranes of the nose and upper respiratory tract is 10-20 ml. After washing the mucous membranes into the nasal cavity, turundas moistened with the drug are introduced into each nasal passage in turn and left for 1 hour. The procedure is repeated 2-3 times a day for 20-40 days. Since ozena and scleroma are chronic diseases, in order to prevent exacerbations, it is recommended to carry out 20-40 day courses of treatment according to the above scheme once a year. When treating sore throats, pharyngitis, laryngitis, the drug is used for rinsing the mouth and pharynx 3 times a day, 10- 20 ml, course of treatment is 7-10 days. For the treatment of bronchitis and pneumonia, the drug is taken orally 3 times a day, 10-20 ml, and also used in the form of aerosols and inhalations (without heating and the use of ultrasound), course of treatment is 15-20 days In the treatment of otitis media, the drug is used for washing and introducing 2-5 ml into the middle ear cavity 1-3 times a day. The course of treatment is 7-15 days. When treating inflammation of the sinuses, the drug is used to rinse the nasal cavity, nasopharynx and sinuses in a dose of 5-10 ml and administer 2-3 ml into the sinuses. The procedure is repeated once daily for 7-10 days. In addition, the drug is administered into the nasal cavity in the form of turundas moistened with bacteriophage, in turn into each nasal passage and left for 0.5-1 hour. The procedure is repeated 3 times a day, the course of treatment is 7-15 days. In the treatment of stomatitis and chronic periodontitis, the drug is used in the form of mouth rinses 3-4 times a day in a dose of 10-20 ml, as well as by introducing turundas impregnated with bacteriophage into periodontal pockets Klebsiella, for 5-10 minutes, course of treatment is 7-10 days. For conjunctivitis and keratoconjunctivitis, the drug is used 2-3 drops 4-5 times a day, course of treatment is 5-7 days; for a purulent corneal ulcer – 4-5 drops per day for 7-10 days; for purulent iridocyclitis - 6-8 drops every 3 hours in combination with oral administration in therapeutic dosages for 7-10 days. For abscesses after opening and removal of purulent contents, the drug is administered in an amount less than the volume of removed pus once daily, course of treatment 7-10 days. For peritonitis and pleurisy, the drug is administered into the drained cavities - abdominal and pleural through drainage tubes, 20-70 ml once daily, the course of treatment is 10-15 days. For osteomyelitis, the drug is administered into the wound cavity through turundas, drainages in the amount of 10-15 days. 30 ml once daily, course of treatment is 15-20 days. When treating suppurative wounds, the drug is used in the form of irrigation, applications, dressings, injection into drainage in a dose of 5-50 ml depending on the lesion at least once a day, course of treatment 10 -15 days. In the treatment of purulent-inflammatory gynecological diseases (suppuration of wounds, endometritis, vulvitis, bartholinitis, colpitis, salpingo-oophoritis), the drug is used for irrigation, applications, injected into the cavities of wounds, vagina, uterus, 5-20 ml once a day. for 7-10 days. For cystitis, pyelonephritis, urethritis, the drug is taken orally in a therapeutic dose 3 times a day 1 hour before meals for 10-20 days. If the cavity of the bladder or renal pelvis is drained, the drug is administered through a cystostomy or nephrostomy 1-3 times a day, 20-50 ml into the bladder and 5-7 ml into the renal pelvis, the course of treatment is 7-15 days. gastoenterocolitis, pancreatitis, cholecystitis, as well as intestinal dysbiosis, the bacteriophage is taken orally in age-specific dosages 3 times a day 1 hour before meals for 7-15 days (according to clinical indications). For indomitable vomiting, the drug is used in the form of high enemas 2-3 times a day, 20-40 ml. In case of intestinal dysbiosis, the drug can be used with normal flora preparations. To prevent hospital-acquired surgical infections, the drug is used to treat postoperative and newly infected wounds in a dose of 5-50 ml depending on the lesion, once daily for 5-7 days. Use of the drug in children under 1 year (including premature babies) For gastoenterocolitis, pneumonia and neonatal sepsis, the drug is used by mouth 2-3 times a day, 3-5 ml 30 minutes before feeding. In cases of indomitable vomiting, the drug is used in the form of high enemas (through a gas outlet tube or catheter) once daily in a dose of 5-10 ml. A combination of rectal (in the form of high enemas) and oral administration of the drug is possible. The course of treatment is 7-15 days (according to clinical indications). In case of a recurrent course of the disease, repeated courses of treatment are possible. In order to prevent the occurrence of nosocomial infection in newborns, the bacteriophage is used according to epidemic indications orally 3-5 ml 3 times a day 30 minutes before feeding during the entire period of hospital stay. For the treatment of omphalitis , pyoderma, infected wounds, the bacteriophage is used in the form of applications of 5-10 ml 2-3 times a day (a gauze cloth is moistened with the bacteriophage and applied to the umbilical wound or affected area of skin) for 7-15 days. The use of the drug does not exclude the use of other antibacterial and anti-inflammatory drugs.
