Using Kornam medicine to treat cats

Pharmacodynamics and pharmacokinetics

Terazosin is an α1-adrenergic blocker that is capable of selectively blocking α1-adrenergic receptors in the smooth muscles of the celiac vessels, prostate vessels, and the bladder neck. As an antihypertensive drug, it dilates large resistance vessels and reduces peripheral vascular resistance, and activates the RAS (renin-angiotensin-aldosterone) system.

Relaxation of the smooth muscles of the bladder neck and contractile elements of the prostate helps reduce the dysuric phenomenon, for example, with adenoma. Due to a decrease in the level of total cholesterol , triglycerides, and an increase in HDL levels, the lipid profile in plasma is normalized. Long-term therapy leads to regression of left ventricular hypertrophy.

Pharmacokinetics of Terazosin

After oral administration, Terazosin undergoes rapid, almost complete absorption (bioavailability over 90%). Presystemic biotransformation is insignificant, therefore, only 1 hour is needed to achieve maximum plasma concentration. In plasma, 90–94% of the substance is bound to proteins. Metabolism in the liver occurs until the formation of 4 metabolites.

The half-life is no more than 12 hours, approximately 40% is excreted by the kidneys (up to 10% is unchanged Terazosin), the remaining 60% is excreted through the intestines (more than 50% are biodegradation products). If the patient has liver pathology, there may be a decrease in clearance and a prolongation of pharmacological effects.

Terazosin

Before treating patients with benign prostatic hyperplasia with Terazosin, prostate malignancy or other causes of urinary retention should be excluded. The effectiveness of the therapy is assessed after 4-6 weeks of treatment with maintenance doses of Terazosin. A reduction in the symptoms of benign prostatic hyperplasia is possible already in the second week of therapy, but the onset of the therapeutic effect may take up to 6 weeks or more.

Treatment with the drug should be discontinued if the patient develops complications from the urinary tract, as well as if the resulting side effects are more serious than the symptoms of benign prostatic hyperplasia. Regardless of the indications for which Terazosin is taken, in order to avoid the development of the “first dose effect,” the initial dose of Terazosin should not exceed 1 mg.

To reduce the risk of developing orthostatic arterial hypotension (“first dose effect”), the first dose of Terazosin is recommended to be taken in the evening before bedtime, after which the patient should remain in bed for 6-8 hours. The risk of a pronounced decrease in blood pressure is highest in within 30-90 minutes after taking the drug, and is also increased in patients simultaneously receiving beta-blockers and diuretics, with a decrease in circulating blood volume, a low-salt diet, and also when resuming treatment with Terazosin after a break (several days).

The patient must be informed that at the first signs of orthostatic hypotension (dizziness, weakness), the patient should sit up or

lie down and remain in this position until you feel better, as well as an increased risk of developing a pronounced decrease in blood pressure when drinking alcohol, standing for long periods or doing physical exercise, as well as at high ambient temperatures.

Caution should be exercised when simultaneous use of Terazosin with thiazide diuretics or other antihypertensive drugs; if combination therapy is necessary, the dose of Terazosin is reduced.

Due to the manifestation of the vasodilatory effect, the drug Terazosin should be used with caution in patients with coronary heart disease or other heart diseases: pulmonary edema with aortic or mitral stenosis, heart failure with increased cardiac output, right ventricular failure due to pulmonary embolism or exudative pericarditis, left ventricular failure with low ventricular filling pressure.

In the case of cataract surgery in patients who previously received alpha-blockers, intraoperative iris instability syndrome is observed. This phenomenon is a variant of small pupil syndrome. When performing surgery (for cataracts), it is necessary to inform the ophthalmologist about the use of alpha 1-adrenergic receptor blockers. Preoperative interruption of alpha-blocker therapy has no advantage over continuation of therapy.

When used in patients with impaired liver function, caution should be exercised due to the fact that terazosin is metabolized in the liver. There are no data on the use of Terazosin in patients with severe hepatic impairment.

During treatment, the concentration of prostate specific antigen does not change.

Terazosin may affect plasma renin activity and the excretion of vanillylmandelic acid by the kidneys. This should be taken into account when conducting laboratory studies.

There are reports of cases of the development of prolonged erection and priapism during therapy with alpha1-blockers. If an erection persists for more than 4 hours, you should immediately seek medical help. If priapism therapy is not carried out immediately, it can lead to damage to the tissue of the penis and irreversible loss of potency.

The selection of a maintenance dose of Terazosin in elderly patients, especially in patients with benign prostatic hyperplasia aged over 65 years, is recommended to be done with caution under medical supervision, due to the high risk of developing orthostatic hypotension in this group of patients. As you age, your risk of dizziness, blurred vision and fainting increases. In patients over 75 years of age, the effectiveness of terazosin is reduced.

Side effects

The use of Terazosin may cause the following undesirable reactions:

• weakness and fatigue;
• drowsiness, anxiety, headaches, dizziness;
• paresthesia (feelings of numbness, tingling);
• decreased libido;
• visual impairment, hearing impairment (noise);
• hypotension , tachycardia , arrhythmia ;
• peripheral edema;
• bronchitis , cough;
• xerostomia , pharyngitis , dyspeptic disorders;
• arthralgia , myalgia ;
• decrease in hemoglobin , as well as hematocrit , development of leukopenia , hypoalbuminemia , hypoproteinemia ;
• allergic reactions are possible ;
• influenza-like syndrome.

Attention! A “first dose phenomenon” may occur , usually accompanied by a decrease , and even orthostatic collapse . This body reaction may occur after the first dose, especially in combination with diuretics or beta-blockers .

Side effects

Most often, adverse events occur when the dosage of the drug is incorrect. Therefore, it is necessary to strictly follow the treatment regimen and not exceed the prescribed amount of the drug.

In addition, immediately after the pet has swallowed the tablet, it should be closely monitored. The animal may experience negative symptoms such as:

• drowsiness and apathy;
• asthenia;
• cardiopalmus;
• visual impairment;
• increased anxiety, in some cases aggression;
• dyspeptic symptoms - nausea, vomiting, rarely - diarrhea.

If one or more signs occur, you should stop treatment and consult your doctor.

To alleviate the animal’s condition, you can feed it a small amount of any sorbent - activated carbon, Enterosgel, Smecta.

Overdose

Symptoms

Tachycardia , hypotension , orthostatic collapse .

First aid and treatment

Transfer the patient to a horizontal position so that the head end of the bed is lowered. In addition, intravenous fluid and hypertensive medications are recommended.

It is known that hemodialysis is ineffective, and there is no specific antidote .

Reviews

Reviews about the drug Terazosin are mostly positive.

Marina, Volgograd: “In our family there lives an old cat, everyone’s favorite. As he grew older, he began to have problems with urination, and we were forced to go to a veterinary hospital for help. The drug Terazosin tablets was prescribed.

The pet immediately refused food with the medicine mixed into it. They gave it to him in parts, placed it on the back of his tongue, and he swallowed it himself. Improvement occurred within 10 days, the pet’s well-being improved.”

Roman, Vladivostok: “Despite the fact that our cat was not yet a year old, he began to have problems with his kidneys, and a veterinarian I knew advised him to treat him with Terazosin.

They gave him 1/2 of a crushed tablet with food every evening, he did not refuse food and quickly began to recover. But since the disease was severe, treatment had to be continued for almost 2 months without a break. But now our pet is completely healthy.”

Anastasia, specialist at a veterinary clinic, Chelyabinsk: “Terazosin is a proven drug with good diuretic and antihypertensive properties. They can treat kidney problems and control blood pressure not only in humans, but also in animals.

The main condition for a quick recovery is not to exceed the recommended dosage and not to interrupt treatment. In addition, during the therapeutic course, the animal must be under the supervision of a doctor.”

Terazosin analogues

Level 4 ATX code matches:
Dalfaz

Sonirid Duo

Setegis

Sonizin

Omnik Okas

Omnic

Proflosin

Urorek

Tamsulosin

Adenorm

Omics

Focusin

Analogs of the drug that match the active compound:

• Cornam (dosage 5 mg, package No. 30, price from 800 rub.);
• Setegis (dosage 5 mg, package No. 30, price from 1100 rubles);
• Terazosin-Teva;
• Haytrin.

Another well-known α-adrenolytic , antidysuric drug is Tamsulosin (Terazosin has more side effects). However, the use of Tamsulosin is effective only for prostate adenoma . The drug is Czech-made, the average price for package No. 30 is 560 rubles.

Analogues and cost

The average cost of the drug is about 325 rubles per package containing 20 tablets of 2 mg. You can buy it at a pharmacy with a doctor's prescription.

A drug similar in pharmacological properties to Terazosin is Setegis. The active ingredient of this drug is also terazosin. When administered to the stomach, this drug begins to act within 15 minutes and continues throughout the day. The average cost of a package of 30 2 mg tablets is 850-900 rubles.

Kidney and urinary tract diseases in pets can be treated with medications created for humans. They have a similar pharmacological effect on the animal’s body.

Terazosin is an effective drug, but the therapeutic course until complete recovery should be several weeks. The drug is given to animals orally; interrupting treatment is not recommended.

Only a veterinarian should prescribe this medication to pets. Otherwise, the cat's health may be seriously harmed.

Side effects

When treating a cat with Kornam, side effects may occur:

• sleepy state
• asthenia;
• increased heart rate;
• decreased quality of vision;
• increased anxiety;
• nausea.

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It is contraindicated for cats to take Kornam if they are intolerant to some of its components, have chronic infectious diseases of the urinary tract, or have kidney stones.

The drug can be bought at a regular pharmacy and is inexpensive. If you are short on time, it will be much faster to order Cornam through the online store.

Cornam, if followed by your veterinarian, will help restore your cat's health.

Active ingredient of the drug

The medicine Kornam is available in the form of flat round tablets of yellow or light orange color. On one side there is a notch, thanks to which you can easily divide the dose in half. The tablets are packaged in blisters of 10 pieces. The plates are packed in cardboard boxes of 2 or 3 pieces.

The active ingredient of the drug Cornam is terazosin in the form of hydrochloride dihydrate. Tablets are available in different dosages - 2 or 5 mg. The drug also contains other components:

• lactose monohydrate;
• microcrystalline cellulose;
• corn starch;
• talc;
• magnesium stearate;
• anhydrous silica;
• iron oxide.

The cost of the medicine Kornam depends on the manufacturer and dosage and ranges from 300 to 700 rubles per pack of 20 tablets. This drug should be stored in a dry place at a temperature of +15 to +30 degrees.

Terazosin drug interactions

With the simultaneous administration of terazosin and antihypertensive drugs of other groups, the hypotensive effect is potentiated. No clinically significant interaction has been identified with simultaneous use with NSAIDs, analgesics, antibiotics, angicholinergics, sympathomimetic drugs, uricosurics, antihistamines, lipid-lowering drugs, corticosteroids, antacids, sedatives, tranquilizers, diuretics and beta-adrenergic receptor blockers.

List of pharmacies where you can buy Terazosin:

• Moscow
• Saint Petersburg

Use of the drug Terazosin

For benign prostatic hypertrophy, the initial dose is 1 mg/day at bedtime. Gradually increase the dose to 2–10 mg/day until the optimal effect is achieved. The daily dose is 10 mg. The therapeutic effect is usually observed within 2 weeks from the start of treatment. To achieve a lasting effect, the course of treatment should be 4–6 weeks. For hypertension (arterial hypertension), an initial dose of 1 mg/day is prescribed before bedtime. Gradually increase the dose until the desired effect is achieved. The maintenance dose is 1–10 mg 1 time per day. The maximum daily dose is 20 mg. In case of temporary discontinuation of terazosin, treatment is resumed according to the same regimen.