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Wobenzym 40 pcs. enteric tablets in Moscow

Inside.

Take without chewing, at least 30 minutes before meals or 2 hours after meals, with water (150 ml).

Adults.

Traditionally, the drug is prescribed in a minimum therapeutic dosage of 3 tablets. 3 times a day for a course of 2 to 5 weeks.

For moderate disease activity, WOBENZYM is prescribed in a dose of 5 tablets. 3 times a day, course from 2 to 4 weeks. If the patient's condition improves, the dose of the drug from the 2nd week can be reduced to 3 tablets. 3 times a day. To achieve a long-term effect, it is recommended to carry out repeated courses of the drug for 1.5–2 months with a two-week break.

If the disease activity is high, WOBENZYM is prescribed in a dose of 7 tablets. 3 times a day, course - 3 weeks. If the condition improves, the dose of the drug can be reduced from the 2nd week to 3 tablets. 3 times a day with continuation of the course for up to 1.5 months. The duration of treatment is determined by the doctor.

For chronic long-term diseases, WOBENZYM can be used according to indications in courses of 3 to 6 months with breaks of 2-4 weeks.

During operations.

During planned operations, the drug is used to prevent the development of complications (inflammation, keloid scar, adhesive disease). The drug is prescribed before surgery, 3 tablets. 3 times a day for a course of 5 days; 3 days before surgery, stop taking the drug.

With antibiotics.

To increase the effectiveness of antibiotics and reduce the severity of side effects, as well as to prevent dysbiosis, the drug is prescribed for the entire course of antibiotic therapy in a dose of 5 tablets. 3 times a day. After completing a course of antibiotics to restore the intestinal microflora, WOBENZYM is recommended to take 3 tablets. 3 times a day for 7–14 days.

During chemotherapy.

To prevent infectious complications, improve tolerability and improve quality of life, the drug is prescribed as “cover” therapy during chemotherapy and radiation therapy, 5 tablets. 3 times a day until the end of the course of chemotherapy and radiation therapy. After completing the course of chemotherapy, the drug is prescribed to restore immunity, 3 tablets. 3 times a day; course - 3 weeks.

For prevention.

When using the drug WOBENZYM for prophylactic purposes, to increase the threshold of adaptation, resistance to diseases and reduce the risk of diseases and vascular accidents, it is recommended to use the drug in 2-3 tablets. 3 times a day. The course is from 3 weeks to 1.5 months, repeated 2-3 times a year.

Children.

At an early age, children have difficulty swallowing tablets, so WOBENZYM is recommended for children from 5 years of age. The drug is prescribed at the rate of 1 tablet. for 6 kg of child’s weight 2 times a day. Take the drug without biting, 30 minutes before meals, or 2 hours after meals, with water. The duration of the course of treatment can be from 2 to 5 weeks, depending on the diagnosis and condition of the child, and is determined by the doctor.

The dose of the drug should be calculated individually for each child under 12 years of age. From 12 years of age, the drug is prescribed according to the regimen for adults: 3 tablets. 3 times a day; course - from 2 to 5 weeks, the duration of treatment is determined by the doctor and depends on the severity of the disease.

For infectious diseases in children, the drug is recommended to be taken together with antibiotics in order to increase their effectiveness during the entire course of antibiotic therapy in a dosage according to the age and weight of the child.

To restore the intestinal ecology and increase immunity after completion of antibacterial and etiotropic anti-infective therapy, the drug is prescribed in 1 tablet. 2 times a day, from 12 years of age the drug is prescribed 2 tablets. 2 times a day; The recommended course is from 1 to 3 weeks, the duration of use of the drug is determined by the doctor.

For recurrent inflammatory diseases in children who are often and long-term ill, the drug is recommended to be taken in 2 tablets. 2 times a day for a course of 3–6 weeks or in a dosage according to the age and weight of the child.

To achieve stable remission and improve the condition of frequently and long-term ill children, it is recommended to carry out several repeated courses of the drug per year for 3–6 weeks with a break of 1–2 weeks. The dosage and duration of use of the drug in frequently ill children depends on the severity of the disease and is determined by the doctor.

Wobenzym

It is used in complex therapy
of the following diseases:

Angiology:

thrombophlebitis, treatment of postthrombophlebitis disease and acute thrombophlebitis of superficial veins, endarteritis and obliterating atherosclerosis of the arteries of the lower extremities, prevention of recurrent phlebitis, lymphedema.

Urology:

cystitis, cystopyelitis, prostatitis, sexually transmitted infections.

Gynecology:

chronic genital infections, adnexitis, gestosis, mastopathy, to reduce the frequency and severity of side effects of hormone replacement therapy.

Cardiology:

angina pectoris subacute stage of myocardial infarction (to improve the rheological properties of blood).

Pulmonology:

sinusitis, bronchitis, pneumonia.

Gastroenterology:

pancreatitis, hepatitis.

Nephrology:

pyelonephritis, glomerulonephritis.

Endocrinology:

diabetic angiopathy, diabetic retinopathy, autoimmune thyroiditis.

Rheumatology:

rheumatoid arthritis, reactive arthritis, ankylosing spondylitis.

Dermatology:

atopic dermatitis, acne.

Surgery:

prevention and treatment of postoperative complications (inflammation, thrombosis, edema), adhesive disease, post-traumatic and lymphatic edema, plastic and reconstructive surgery.

Traumatology:

injuries, fractures, distortions, ligamentous injuries, bruises, chronic post-traumatic processes, inflammation of soft tissues, burns, injuries in sports medicine.

Neurology:

multiple sclerosis.

Pediatrics:

atopic dermatitis, infectious and inflammatory diseases of the respiratory tract (inflammation of the upper and lower respiratory tract, pneumonia), juvenile rheumatoid arthritis, prevention and treatment of postoperative complications (suppuration and poor wound healing, formation of adhesions, local edema).

Ophthalmology:

uveitis, iridocyclitis, hemophthalmos, diabetic retinopathy, ophthalmic surgery.

Prevention:

microcirculation disorders, post-stress disorders, as well as failure of adaptation mechanisms. Prevention of side effects of hormone replacement therapy, hormonal contraception. During surgical interventions to prevent infectious complications and adhesions.

WOBENZYM

recommended for the prevention of infectious complications and improvement of quality of life during chemotherapy or radiation therapy. Prevention of the development of viral infections and their complications.

Wobenzym plus No. 40 tablet p.o. solution/intestinal

Instructions for medical use of the drug Wobenzym plus Trade name Wobenzym plus International nonproprietary name No Dosage form Enteric-coated tablets Composition One tablet contains active substances: bromelain – 450 FIP-ED trypsin – 1440 FIP-ED (24 μkat) rutoside trihydrate – 100 mg, excipients: lactose monohydrate, pregelatinized starch, magnesium stearate, stearic acid 70, colloidal anhydrous silicon dioxide, talc. shell composition: macrogol 6000, methacrylic acid – methyl methyl acrylate copolymer (1:1), talc, triethyl citrate, vanillin. Description Tablets are round in shape, with a biconvex and smooth surface, coated with a yellowish-green film coating. Pharmacotherapeutic group Other therapeutic products ATC code V03A Pharmacological properties Pharmacokinetics Absorption and distribution: Large molecular substances, such as the enzymes contained in Wobenzym plus, are absorbed from the gastrointestinal tract through various cell-mediated mechanisms and bind to transport proteins in the blood (alpha- 1-antitrypsin, alpha-2-macroglobulin). After oral administration of enzymes, a good correlation is observed between plasma concentrations of trypsin or bromelain and the dose taken. Therapeutic concentrations are achieved within 4 days of taking the drug. Active substances in combination with blood transport proteins (alpha-1-antitrypsin, alpha-2-macroglobulin) bind to cellular receptors and are subsequently excreted through the mononuclear phagocyte system, as well as other mechanisms. Unabsorbed hydrolases and rutoside are excreted in the feces, provided they are not denatured or digested. Pharmacodynamics Wobenzym Plus improves the functional state of blood cells and the vascular wall, reduces blood viscosity and the risk of blood clots in blood vessels, and promotes the dissolution of already formed blood clots. The enzymes bromelain, trypsin and rutoside have an effect on edema of inflammatory and non-inflammatory origin (soft tissue damage, sports injuries), as a result, the pain syndrome is reduced, which is explained by the direct proteolysis of inflammatory mediators by the enzymes included in Wobenzym plus, as well as by reducing the oncotic pressure at the site of inflammation. This leads to a reduction in swelling, tissue tension and pressure on nerve endings. Wobenzym Plus improves microcirculation in areas of inflammation, increases the delivery of oxygen and nutrients (blood supply), thereby stimulating reparative processes in chronic diseases and in the postoperative period. Wobenzym Plus improves blood supply to the bronchi and lung tissue in chronic respiratory diseases, thins mucus, improves the function of the ciliated epithelium and restores the drainage function of the bronchi. The enzymes bromelain and trypsin have been tested in vitro and in vivo to inhibit the formation of (pathogenic) immune complexes, activate unstimulated mononuclear cells and reduce the expression of adhesion molecules (e.g. CD 44, CD 54, also known as ICAM - 1). Wobenzym Plus increases the effectiveness of antibiotics by improving microcirculation and blood supply to the site of inflammation. Wobenzym Plus does not replace antibiotic treatment for infectious inflammation, but increases their effectiveness. Indications for use In complex therapy: - post-traumatic and postoperative edema - lymphatic edema and microcirculatory disorders - phlebitis, post-thrombotic syndrome (condition after repeated inflammation of the veins), trophic ulcers; - acute and chronic inflammation of the genitourinary tract in men: cystitis, urethritis, cystopyelitis, prostatitis; - acute and chronic inflammatory diseases of the pelvic organs in women: adnexitis, salpingoopharitis; - rheumatoid arthritis, soft tissue rheumatism (for example: muscular rheumatism, tennis elbow syndrome or lateral epicondylitis, frozen shoulder syndrome or adhesive capsulitis of the shoulder joint, tenosynovitis), degenerative diseases of the joints and spine. Can be used in adults and children over 6 years of age. Method of administration and dosage: Take the tablets orally, at least 30 minutes before meals, without chewing, with water (200 ml). Adults For therapeutic purposes, take 3 tablets 3 times a day for 2 weeks. In special cases (severe illnesses, acute inflammations, after injuries and in the postoperative period, when rapid relief of swelling, bruising and hemorrhage is necessary), the maximum recommended dose is 12 tablets per day, divided into three doses. For prevention, it is recommended to use 2 tablets 3 times a day for 2 weeks. Children Children from 6 to 12 years old - 1 tablet per 10 kg of child's weight per day. This dose should be divided into two or three doses. From 12 years old according to the adult scheme. Changing the course of administration and dosage of the drug is possible only after consultation with a doctor. Side effects: increased frequency of stool, change in the consistency and smell of stool, which quickly stop with a temporary reduction in the dose of the drug; occasionally, an allergic reaction (skin rash, itching) may occur, which disappears after stopping treatment with the drug - nausea, flatulence, abdominal pain, headache, exanthema, general weakness - a feeling of fullness in the intestines. This can be prevented by dividing the daily dose into a larger number of single doses. Contraindications: individual intolerance, congenital or acquired bleeding disorders (for example, hemophilia) - acute liver diseases, children under 6 years of age. Drug interactions. There have been no cases of incompatibility with other drugs. The use of Wobenzym plus together with antibiotics increases the effectiveness of antibiotic therapy. Special instructions In case of infectious processes, Wobenzym Plus does not replace antibiotics. In case of exacerbation of the disease while taking Wobenzym plus, a temporary dose reduction is recommended and you should consult a doctor. Hemodialysis is possible only after consultation with a doctor. Patients suffering from diabetes should take into account that each tablet of the drug contains 0.015 bread units. Pregnancy and lactation During pregnancy, use with caution, only in cases where the expected benefit of therapy for the mother outweighs the potential risk of side effects in the fetus (only after consultation with a doctor!) Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms The drug does not is a doping agent and does not have a negative effect on driving a car or performing work that requires a high speed of mental and physical reactions. Overdose There are no known cases of drug overdose. Release form and packaging 20 tablets are placed in a blister pack made of polyvinyl chloride film and aluminum foil and/or polyvinyl chloride film, polyethylene and aluminum foil. 2 or 10 blister packs together with instructions for medical use in the state and Russian languages are placed in a cardboard box . Storage conditions Store in a dry place, at a temperature from 15°C to 25°C. Keep out of the reach of children! Shelf life: 2 years After the expiration date indicated on the package, do not use! Conditions for dispensing from pharmacies Without a prescription Manufacturer MUKOS Emulsions GmbH, Germany. D-13509 Berlin, Germany Registration certificate holder MUKOS Pharma TsZ s.r.o., Pruchones, Czech Republic Address of the organization that accepts claims from consumers on the quality of products (products) in the territory of the Republic of Kazakhstan and is responsible for post-registration monitoring of the safety of the medicinal product. Representative office of MUCOS Pharma CZ SRO in the Republic of Kazakhstan. 050026, Republic of Kazakhstan, Almaty, st. Muratbaeva 62, off. 68