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Manufacturers: Central European Pharmaceutical Company
Active ingredients
- Zinc 2-chloropropionate
Disease class
- Carcinoma in situ of other and unspecified digestive organs
- Benign neoplasm of the mouth and pharynx
- Benign neoplasm of the major salivary glands
- Seborrheic keratosis
- Anogenital (venereal) warts
- Viral warts
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Anticoagulant
- Dehydrating
Pharmacological group
- Other drugs regulating the function of the genitourinary system and reproduction
Solution for topical use Mardil Zink Maks
Instructions for medical use of the drug
Description of pharmacological action
Mardil Zinc® Max is a 50% aqueous solution of zinc chloropropionate and 2-chloropropionic acid. When applied externally and locally to affected areas of the skin or mucous membrane, the drug is able to interrupt the growth and vital activity of pathologically altered cells and tissues, incl. benign neoplasms of the skin and mucous membrane, through anticoagulation, dehydration and devitalization. When applied to affected areas, the drug leads to fixation and subsequent mummification of the pathologically altered tissue with which the drug comes into contact. The immediate effect of the drug is expressed in discoloration of the skin and mucous membrane with the appearance of a characteristic pale gray tint. Subsequently, the devitalized pathological tissue dries out and changes color to dark brown due to mummification. Mummified scabs are separated only after complete re-epithelialization spontaneously after 2-3 weeks. Healing proceeds without complications, especially in the absence of secondary infection, without leaving significant scars or scars, deformation of adjacent tissues or dysfunction of organs.
Indications for use
Treatment of skin and mucous membrane lesions: - vulgar warts; - plantar warts; - flat warts; - anogenital warts; - acrochordons (cutaneous horn); - seborrheic keratomas; - seboroids; — benign nevi (low-pigment, non-pigment, papillomatous, fibroepithelial, Setton’s nevi), tested for benignity.
Release form
Solution for topical use 1 ml of zinc 2-chloropropionate solution 1.5% in 2-chloropropionic acid 0.5 ml 1 ml - dark glass bottles (1) complete with a set of glass microcapillaries (5 pcs.) - foam containers (1) - cardboard packs .
Pharmacodynamics
Mardil Zinc® Max is a 50% aqueous solution of zinc chloropropionate and 2-chloropropionic acid. When applied externally and locally to affected areas of the skin or mucous membrane, the drug is able to interrupt the growth and vital activity of pathologically altered cells and tissues, incl. benign neoplasms of the skin and mucous membrane, through anticoagulation, dehydration and devitalization. When applied to affected areas, the drug leads to fixation and subsequent mummification of the pathologically altered tissue with which the drug comes into contact. The immediate effect of the drug is expressed in discoloration of the skin and mucous membrane with the appearance of a characteristic pale gray tint. Subsequently, the devitalized pathological tissue dries out and changes color to dark brown due to mummification. Mummified scabs are separated only after complete re-epithelialization spontaneously after 2-3 weeks. Healing proceeds without complications, especially in the absence of secondary infection, without leaving significant scars or scars, deformation of adjacent tissues or dysfunction of organs.
Pharmacokinetics
When applied to affected areas of the skin or mucous membrane, Mardil Zinc® Max is not absorbed and does not have a systemic effect on the body.
Use during pregnancy
Studies to study the possible effect of the drug on the body of pregnant women and nursing mothers have not yet been conducted. Treatment in this category of patients should be prescribed only in cases where the potential benefit to the mother outweighs the possible risk to the fetus or child.
Contraindications for use
- malignant neoplasms of the skin and mucous membrane; - pronounced tendency to form keloids; - pregnancy; - lactation period; — age up to 18 years; - hypersensitivity to the components of the drug.
Side effects
The use of Mardil Zinc® Max in rare cases can lead to changes in skin pigmentation and the formation of superficial skin scars. With the normal course of the epithelization process, the absence of secondary infection and the spontaneous separation of mummified scabs, the likelihood of such negative consequences is extremely insignificant. Swelling of the tissue may be observed, very rarely; with individual sensitivity to the components of the drug, allergic reactions in the form of skin itching are possible.
Directions for use and doses
For external use The treatment process is carried out on an outpatient basis under the supervision of a physician. The procedure does not require anesthesia. The drug is applied with a plastic spatula, a cotton swab or using a glass capillary on the surface of the formation, previously degreased with 70% alcohol. Treatment is carried out 1-3 applications until a whitish-gray color appears. The color of the tissue changes within 2-3 minutes after application of the drug. In the presence of severe hyperkeratosis, within 5-7 minutes. At the same time, the consistency of the neoplasm changes to a denser one. The dosage of the drug depends on the type, size, density and severity of hyperkeratosis and can be 0.02 ml-0.2 ml. The maximum daily dose is 0.2 ml. The number of treatment sessions varies from 1 (flat warts) to 3-4 (plantar warts) until the element completely disappears with an interval between sessions of at least 24 hours. A transient strip of hyperemia and edema is observed around the neoplasm after application of the drug Mardil Zinc® Max , which disappears without a trace 25-40 minutes after completion of the procedure. No additional therapeutic measures are required after application of the drug. The next day after application, the pathological lesion mummifies, acquires a dark brown tint and sharply decreases in size. Mummified scabs are separated only after complete epithelialization spontaneously after 2-3 weeks. Healing proceeds without complications, especially in the absence of secondary infection, without leaving significant scars, scars or deformations of adjacent tissues or dysfunction of organs. For topical use Treatment of anogenital warts. Treatment is carried out on an outpatient basis under the supervision of a physician; the procedure does not require anesthesia. The drug is applied with a universal probe or applicator. After applying the drug, the color of the tissue changes to a whitish-gray color. The volume of the applied drug depends on the size of the formation and the affected area and can range from 0.02 ml to 0.2 ml. During each procedure, no more than 2-3 lesions with a total area of up to 3 cm2 can be treated. The maximum daily dose is 0.2 ml. In the presence of more extensive lesions, treatment with the drug should be carried out in several stages with an interval of at least 24 hours. When applying the drug Mardil Zinc® Max, slight swelling of the mucous membrane occurs. Within 2-3 days after using the drug, necrotic tissue is rejected. Complete regeneration is observed within 10-14 days. For large anogenital warts in case of incomplete necrosis, the drug can be re-applied after 5-7 days.
Overdose
If the drug is used incorrectly, erosions may form. In order to prevent acid burn, the drug must be washed off with running water. Healing can occur on its own without the use of additional medications or with the use of wound healing drugs.
Interactions with other drugs
The interaction of the drug Mardil Zinc® Max with other external medications has not been established.
Special instructions for use
Before opening, shake the bottle and move the solution that gets into the top of the bottle to the bottom. The opened bottle must be in a strictly vertical position. Mardil Zinc® Max contains acid. Avoid contact of the drug with healthy skin or mucous membrane. If there is an accidental contact of Mardil Zinc® Max on healthy skin or mucous membrane, it is necessary to remove the drug as quickly as possible using a cotton swab moistened with water. When treating affected skin areas near the eye area, special precautions should be taken. Avoid getting the drug into your eyes. If Mardil Zinc® Max accidentally gets into your eyes, you should immediately rinse them with plenty of water and 1% sodium bicarbonate solution, and then consult a doctor. A mummified scab should not be removed by scraping or using mechanical means. The scab must separate from healthy skin or mucous membrane on its own, otherwise tissue healing processes may be disrupted and scars may form. Until complete healing of the skin or mucous membrane is achieved, it is not recommended to swim in pools or open water, and exposure to direct sunlight and ultraviolet radiation should be avoided. On the day of treatment, it is recommended to limit water procedures. It is advisable to avoid trauma and contamination of the treated pathological focus until complete epithelialization. Before throwing away the bottle, you should rinse off the remaining drug in running water. The empty bottle can be thrown into the trash container.
Storage conditions
In a dry place, protected from light, at a temperature not exceeding 25 °C.
Best before date
36 months
ATX classification:
G Genitourinary system and sex hormones
G02 Other drugs for the treatment of gynecological diseases
G02CX Other preparations for use in gynecology
About the medicine
The presented medical drug “Mardil Zinc Max” affects the body through dehydration, anticoagulation and devitalization. When used on affected areas, the drug leads to fixation and subsequent mummification of pathologically altered tissues with which the drug comes into contact. The direct effect of this drug can be expressed in discoloration of the integument and mucous membrane with the appearance of a characteristic gray tint.
Subsequently, the devitalized pathological tissues dry out and change color to a brown tint. This happens due to mummification. Mummified scabs may only come off spontaneously after complete re-epithelialization after two to three weeks. Healing occurs, as a rule, without any complications, especially in the absence of secondary infections, without leaving significant scarring and, in addition, deformation of the adjacent tissue or dysfunction of organs.
Similar drugs:
- Mardil Zink Solution for topical use
- Prostagutt mono Capsule
- Prostagutt Aerosol
** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before you start using Mardil Zinc Max, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Mardil Zinc Max is provided for informational purposes only and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Contents and release format
The product "Mardil Zinc Max" is produced in the form of a solution for topical use. The drug is a fifty percent aqueous solution of chloropropionic acid and zinc chloropropionate. 1 milliliter contains 0.5 milliliters of zinc. The product is placed in dark glass bottles. The kit comes with five glass microcapillaries with a foam container. The medicine is packaged in a cardboard box.
Contraindications
The use of the described medication is prohibited in a number of the following cases:
- For malignant neoplasms of the skin and mucous membrane.
- In case of a pronounced tendency to form keloids.
- During pregnancy, as well as during lactation.
- Age up to eighteen years.
- The appearance of hypersensitivity to the ingredients of the drug.
special instructions
Before opening, shake the bottle and move the solution that gets into the top of the bottle to the bottom. The opened bottle must be in a strictly vertical position. Mardil Zinc® Max contains acid. Avoid contact of the drug with healthy skin or mucous membrane. If there is an accidental contact of Mardil Zinc® Max on healthy skin or mucous membrane, it is necessary to remove the drug as quickly as possible using a cotton swab moistened with water. When treating affected skin areas near the eye area, special precautions should be taken. Avoid getting the drug into your eyes. If Mardil Zinc® Max accidentally gets into your eyes, you must immediately rinse them with plenty of water and a 1% sodium bicarbonate solution, and then consult a doctor. You cannot remove a mummified scab by scraping or using mechanical means. The scab must separate from healthy skin or mucous membrane on its own, otherwise tissue healing processes may be disrupted and scars may form. Until complete healing of the skin or mucous membrane is achieved, it is not recommended to swim in pools or open water, and exposure to direct sunlight and ultraviolet radiation should be avoided. On the day of treatment, it is recommended to limit water procedures. It is advisable to avoid traumatization and contamination of the treated pathological focus until complete epithelialization. Before throwing away the bottle, the remaining drug should be washed off in running water. The empty bottle can be thrown into the trash container.
By-effect
In accordance with the instructions, the use of Mardil Zinc Max in rare cases can lead to changes in skin pigmentation and the formation of superficial scars. Provided that the epithelization process proceeds normally and there is a complete absence of secondary infection, and, in addition, the mummified scabs separate independently, the likelihood of such negative consequences is very small. Swelling of the tissue may be observed, although very rarely, and in case of individual sensitivity to the ingredients of the drug, various allergic reactions in the form of skin itching are possible.
Indications
"Mardil Zinc Max" is prescribed for the treatment of lesions of the skin and mucous membranes in the following pathologies:
- Against the background of vulgar and anogenital warts.
- In the event of a plantar wart.
- When flat growths occur.
- With acrochordons (cutaneous horn).
- Against the background of seborrheic keratoma and seboroids.
- In case of benign nevi. For example, with low-pigment, non-pigment, papillomatous, fibroepithelial nevus, tested for benignity.