According to a survey conducted by ROSSTAT “Comprehensive monitoring of living conditions of the population 2018”, infectious diseases are the third reason for the independent use of medications as part of self-medication and self-prevention [1]. In such a situation, the pharmaceutical worker is actually the only qualified interlocutor of the buyer who is faced with a choice. Therefore, today, competent pharmaceutical consulting is gaining more and more importance.
The nasal mucosa is a typical “entry gate” for respiratory viruses, therefore, the temporary guidelines of the Russian Ministry of Health for the prevention, diagnosis and treatment of the new coronavirus infection (COVID-2019) dated March 27, 2020 indicate that for nonspecific prevention of coronavirus infection it is recommended to use drugs for topical use with barrier functions. Such drugs and medical devices form a physical barrier on the mucous membrane of the nasal cavity, preventing the adhesion of the virus. The compounds that form the barrier are gradually eliminated due to the work of the mucociliary apparatus. Theoretically, the protective layer will help slow the progression of the disease, since there will be fewer cells available to attack by viruses.
MEDICATIONS
The barrier function in medicinal products is performed by the substances that make up their ointment or gel base. In addition, intranasal medications also contain active ingredients: dioxotetrahydroxytetrahydronaphthalene (“Oksolin”, nasal ointment 0.25%), interferon alpha-2b (“Viferon”, ointment and gel for external and local use; “Infagel” gel for external and local use). However, the effectiveness of their use as declared antiviral agents does not have a sufficient scientific basis.
| Trade name | Excipients | Active ingredients | With caution / Contraindications |
| Oksolin, nasal ointment 0.25% | Liquid paraffin (vaseline oil), petroleum jelly | Dioxotetrahydroxytetrahydronaphthalene | With caution during pregnancy, breastfeeding, contraindication - children under 2 years of age |
| Viferon, gel for external and local use | Alpha tocopherol acetate, methionine, benzoic acid, citric acid monohydrate, sodium tetraborate decahydrate, sodium chloride, human albumin, distilled glycerin (glycerol), sodium carmellose, ethanol 95%, purified water | Interferon alpha-2b human recombinant | Pregnancy and breastfeeding are not a contraindication for use due to the very low absorption of components; use in newborns is possible |
| Viferon, ointment for external and local use | Alpha tocopherol acetate, lanolin anhydrous, medical petrolatum, peach oil, calcium pantothenate, sodium benzoate, human albumin, sodium acetate trihydrate, sodium chloride, disodium edetate dihydrate, purified water | Interferon alpha-2b human recombinant | Possible use during pregnancy and breastfeeding due to very low absorption of components, contraindication - children under 1 year of age |
| Infagel, gel for external and local use | Aluminum hydroxide, polyvinyl alcohol, purified water | Interferon alpha-2b recombinant | Contraindicated for persons suffering from allergic diseases in the acute stage |
Nazaval Plus spray naz doses 500 mg 200 doses pack cards x1
INSTRUCTIONS Information on the medical use of the medical product Nasal powder
Registration number: FSZ 2009/04743 dated 07/08/2009 Trade name: Nazaval PLUS
Ingredients: micronized cellulose of plant origin, wild garlic extract. Excipients: natural peppermint extract.
Description of the medical product: Fine powder of white or close to white color with a slight smell of mint, supplied 500 mg in a polyethylene bottle with a patented dispenser spray and a screw cap. 1 bottle along with instructions for use is placed in a cardboard pack.
PURPOSE: Nazaval PLUS is a fine powder of cellulose and wild garlic extract of plant origin with a slight mint scent in a spray dispenser. Nazaval PLUS acts as a natural barrier on the nasal mucosa and is used to protect against the penetration of viruses and bacteria that enter the upper respiratory tract when air is inhaled. It is a preventive and protective remedy against influenza and colds.
MAIN TECHNICAL CHARACTERISTICS: Nazaval PLUS consists exclusively of natural ingredients: it is natural fine cellulose powder and wild garlic extract of plant origin. Nazaval PLUS does not contain systemically or locally active substances. Nazaval PLUS forms a colorless gel-like coating of the nasal cavity, which is a reliable barrier against viruses and bacteria throughout the day. The powder has a light mint aroma.
MECHANISM OF ACTION: Cellulose powder from the dispenser spray enters the nasal mucosa, binds to the moist surface of the nasal mucosa and forms a transparent gel-like layer lining the nasal cavity and serving as a natural barrier against the penetration of viruses and bacteria.
INDICATIONS FOR USE: Protection of the nasal mucosa from the penetration of viruses and bacteria and other aggressive environmental factors. Nazaval PLUS does not contain active ingredients and does not have a systemic effect and can be used in children and adults, as well as women during pregnancy and lactation.
CONTRAINDICATIONS: Individual intolerance to the components. Do not use if you have an allergic reaction to garlic or a tendency to nosebleeds.
METHOD OF APPLICATION AND DOSES: Injections into the nose - one injection into each nasal passage. Nazaval PLUS can be used in adults and children under adult supervision. You can use Nazaval PLUS as often as necessary: periodically, before possible contact with airborne infections when visiting crowded places. As a rule, using the recommended dosage - one injection into each nasal passage 3-4 times a day (every 5-6 hours) - is enough to provide protection throughout the day. It is recommended to repeat injections of Nazavala PLUS after each blowing of the nose to resume the formation of the protective layer.
PREGNANCY AND LACTATION: Nazaval PLUS can be used by women during pregnancy and breastfeeding, since it does not contain active ingredients, does not have a systemic effect and does not contain preservatives.
PREPARING THE PRODUCT FOR USE: It is recommended to use Nazaval PLUS in advance, 10-15 minutes before intended trips on public transport, planes, trains, etc., as well as when visiting crowded places.
It is recommended to shake the Nazaval PLUS bottle before each use!
ORDER OF OPERATION OF THE PRODUCT: 1. When using for the first time, it is recommended to adjust the dosing device to obtain the optimal dose: to do this, you need to place the dispenser bottle opposite you and, lightly pressing the walls of the bottle, make 2 test injections into the air - you will see a stream of powder. 2. Before use, if necessary, perform hygienic cleaning of the nasal cavity or blow your nose. 3. Pinch one nasal passage with your finger. 4. Place the nose of the Nazaval bottle PLUS the opposite nasal passage and make one injection while inhaling, pressing the walls of the bottle. 5. Hold your breath for 2 seconds and then take a deep, calm breath to allow the powder to penetrate your nasal passages. 6. Repeat this procedure on the opposite side. Nazaval PLUS can be used as often as necessary. Use Nazaval PLUS systematically. It is recommended to reuse after each cleansing of the nasal cavity.
RULES FOR STORAGE AND USE: Shelf life - 3 years. Do not use if the bottle is damaged. Store the bottle closed with the cap tightly screwed on in a dry place protected from children at room temperature. The bottle is recommended to be used within 6 months after opening. Do not use simultaneously with other nasal medications, because this may reduce the effectiveness of Nazaval PLUS. If Nazaval PLUS gets into your eyes, it is recommended to rinse your eyes with water. Do not use after expiration date. Transportation by all types of vehicles is allowed, in accordance with the rules for the transportation of goods in force for this type of transport.
CONDITIONS OF DISCHARGE FROM PHARMACIES: Dispensed without a doctor's prescription.
, Great Britain, Nasaleze Ltd, Unit 6, The Shipyard, Ramsey, Isle of Man, IM8 3DT, UK RU Holder: Pharmaval SA, Switzerland, Pharmaval SA, En Reutet, Case postale 169, 1868, Collombey, Switzerland
Distributor in Russia: Pharmaval LLC, 125481 Moscow, st. Planernaya, 20, building 1
RU number: FSZ 2009/04743 dated 07/08/2009
MEDICAL DEVICES
"Nazaval PLUS"
“Nazaval PLUS” is a finely dispersed cellulose powder, which, when it enters the nasal cavity, binds to mucus and forms a gel-like layer on the mucous membrane that prevents viruses from entering the body. Due to wild garlic extract (allicin and ajoenes), the growth of bacteria and viruses is suppressed, and they are also neutralized [2].
The medical product “Nazaval PLUS” can be used in children and adults, as well as women during pregnancy and breastfeeding.
| Emergency protection | Seasonal protection |
| Before contact with a sick person, in crowded places, in public transport | For daily protection against respiratory viruses all day long |
| 1 injection into each nasal passage while inhaling, once (10-15 minutes before contact, visiting a public place, traveling) | 1 injection into each nasal passage while inhaling 3-4 times a day (every 5-6 hours) |
Natural peppermint extract included in Nazaval PLUS serves as an indicator of proper use. The appearance of a slight mint smell after injection indicates that the powder from the bottle has entered the nasal cavity.
Method of application:
Step 1. Before use, if necessary, hygienically clean the nasal cavity or blow your nose.
Step 2. Gently shake the bottle. When using for the first time, it is recommended to make 2 test injections into the air.
Step 3. Pinch one nasal passage with your finger, inhale the powder into the opposite nasal passage, pressing INTENSIVELY on the walls of the bottle. Repeat the same procedure on the other side.
It is recommended to reuse after each cleansing of the nasal cavity to restore the protective layer.
If it is necessary to use it together with other nasal medications, Nazaval PLUS should be used no earlier than 30 minutes after their use, having previously cleaned the nasal passages. It is not recommended to use Nazaval PLUS after using nasal ointments and oil-based nasal drops.
Also among buyers, the demand for medical products used to protect the nasal mucosa from aeroallergens has increased significantly, since the principle of action is the same.
"Nazaval"
The medical product “Nazaval” available on the pharmaceutical market, like “Nazaval PLUS”, contains fine cellulose powder, but without wild garlic extract. Recommended for protecting the nasal mucosa from allergens and pollutants, as well as other aggressive environmental factors inhaled with air. "Nazaval" can be used in children and adults, as well as women during pregnancy and breastfeeding.
Nazaval Plus nasal spray 500 mg 200 DOZES
Compound
Active ingredients: micronized cellulose of plant origin, wild garlic extract. Excipients: natural peppermint extract.
Indications for use
Nazaval® PLUS is used for the prevention of colds, ARVI (including influenza):
- once: before possible contact with a patient with ARVI, when visiting crowded places as a means of emergency protection;
- daily: during the ARVI season.
Nazaval® PLUS can be used in children and adults, as well as women during pregnancy and breastfeeding.
Contraindications
- individual intolerance to components;
- allergic reactions to garlic;
- tendency to nosebleeds.
Directions for use and doses
Children and adults: one spray into each nasal passage 3-4 times a day (every 5-6 hours).
Typically, this frequency of application is sufficient for protection throughout the day. If necessary, Nazaval® PLUS can be used as often as necessary. It is recommended to use Nazaval® PLUS 10–15 minutes before intended trips on public transport (plane, trains, etc.), when visiting crowded places. Application procedure:
Step 1. Before use, if necessary, hygienically clean the nasal cavity or blow your nose.
Step 2. Gently shake the bottle. When using for the first time, it is recommended to make 1 or 2 test injections into the air.
Step 3. Pinch one nasal passage with your finger, inhale the powder into the opposite nasal passage, pressing INTENSIVELY on the walls of the bottle.
Repeat the same procedure on the other side.
Storage conditions
Store in a dry place at a temperature not exceeding 25 °C. Keep out of the reach of children.
Best before date
3 years.
Do not use after the expiration date stated on the package. The bottle is recommended to be used within 6 months after first opening.
Do not use if the bottle is damaged.
special instructions
The safety of Nazaval® PLUS is due to the lack of interaction with organs and tissues of the body.
Nazaval® PLUS should be used in children under adult supervision. Before each use, it is recommended to hygienically clean the nasal cavity. Contact of the bottle spout with the nasal mucosa should be avoided. This may cause the bottle spout to become clogged with powder. If this does happen, clean the bottle spout with a thin, sharp object (needle, toothpick). If it is necessary to use it together with other nasal medications, Nazaval® PLUS should be used no earlier than 30 minutes after their use, having first cleared the nasal passages.
It is not recommended to use Nazaval® PLUS after using nasal ointments and oil-based nasal drops. If Nazaval® PLUS gets into your eyes, it is recommended to rinse them with water.
Description
Nazaval® PLUS acts as a natural barrier on the nasal mucosa and is used to protect against the penetration of viruses and bacteria that enter the upper respiratory tract when air is inhaled. It is a preventative against ARVI (including influenza) and other colds.
Dosage form
Fine powder of white or almost white color with a slight mint odor.
Use in children
The drug is not contraindicated in childhood and, after consultation with a doctor, can be used even in infants. In order for the medicine to have the expected effect, its administration into the nasal passages in children must be supervised by adults.
Action
The powder of cellulose and wild garlic extract from the dispenser enters the nasal mucosa and forms a transparent, gel-like, protective layer that does not interfere with breathing.
The gel-like layer is an effective barrier against viruses and bacteria, protecting the body from colds and ARVI. Due to its antiseptic properties, wild garlic extract inhibits the growth and neutralizes bacteria and viruses that enter the nasal mucosa with inhaled air.
Nasal spray, dosed Nazaval® PLUS is a barrier agent and does not have a systemic or local effect.
Use during pregnancy and breastfeeding
Nazaval® PLUS can be used during pregnancy and breastfeeding, since it does not have a systemic effect and does not contain preservatives.
Impact on the ability to drive vehicles and operate machinery
The use of the barrier agent Nazaval® PLUS does not affect the ability to drive vehicles and does not cause drowsiness.
special instructions
It is recommended to use the drug in advance, 10–15 minutes before intended trips on public transport, plane, train, etc., as well as before visiting crowded places.
It is recommended to shake the bottle before each use!
How the product works
1. When using for the first time, it is recommended to adjust the dosing device to obtain the optimal dose. To do this, you need to place the dispenser bottle opposite you and, lightly pressing the walls of the bottle, make 2 test injections into the air - a stream of white powder should appear.
2. Before use, if necessary, you should hygienically clean the nasal cavity or blow your nose.
3. Pinch one nasal passage with your finger.
4. Place the spout of the bottle in the opposite nasal passage and make 1 spray while inhaling, pressing on the walls of the bottle.
5. Hold your breath for 2 seconds and then take a deep, calm breath so that the powder penetrates the nasal passage.
6. Repeat the procedure with the other nostril.
The drug can be used as often as necessary. Re-use is recommended after each nasal cleansing.
Do not use simultaneously with other drugs for the nose, because this may reduce the effectiveness of Nazaval Plus.
In case of contact with eyes, it is recommended to rinse them with water.
Do not use if the bottle is damaged.
Directions for use and doses
Intranasally, as necessary, periodically, when visiting crowded places (to avoid airborne infection).
In adults and children (under adult supervision): 1 spray in each nasal passage 3-4 times a day (every 6-8 hours) - as a rule, the recommended dosage is sufficient for protection throughout the day.
It is recommended to repeat spraying the drug after each blowing of the nose to resume the formation of a protective film.
