Metaprebiotic STIMBIFID PLUS is a further development and deep optimization of the prebiotic Stimbifid and consists of two components - prebiotic and metabiotic.
A narrowly targeted prebiotic component - natural fructooligosaccharides (FOS) and fructopolysaccharides (FPS) with an optimized ratio of short (GFn, n = 2-8) and long (GFn, n = 2-60) chains, which ensures the supply of bifidobacteria with exclusive nutrition along the entire length of the thick intestines.
The metabiotic component is calcium lactate. It is a powerful stimulator of growth and reproduction of normobiota (RF patents).
Recommendations for use:
The intestinal microbiota of a healthy person consists of 90% bifidobacteria - microorganisms necessary for normal human life.
Poor nutrition, bad habits, adverse environmental influences, and the use of antibiotics reduce the number of bifidobacteria in the intestines, and their place is immediately taken by pathogenic microbes harmful to humans.
This disturbance of the biological balance between opportunistic and beneficial microbiota is called dysbiosis, which leads to a significant decrease in colonization resistance of the gastrointestinal mucosa. Unfortunately, currently about 95% of the Russian population suffers from intestinal dysbiosis.
With this clinical and laboratory syndrome, normal digestion is disrupted, diarrhea or constipation, cramping pain in the abdominal area, increased gas formation, and allergic reactions appear. In the future, this condition leads to deterioration of the liver and pancreas, decreased immunity, thrombus formation, diseases of the musculoskeletal system and other pathologies.
Reviews
Patients and doctors agree that Stimbifide is an indispensable dietary supplement. It is one of the most powerful prebiotics and is considered the optimal tool for improving intestinal functioning, prevention and complex treatment of dysbiosis, gastrointestinal disorders and diseases caused by dysbacteriosis.
A list of reviews about Stimbifide is presented at the end of the article. If you have experience using dietary supplements, please describe it. With this you will help our readers who are just planning to use the drug.
Description of composition and action:
Metaprebiotic STIMBIFID PLUS* is an innovative development of Russian scientists of the Scientific Society "Microbiota" based on in-depth fundamental research of intestinal microbiota, as well as safe and effective methods for its correction. The research formed the basis of the “Scientific Discovery” and is protected by three patents of the Russian Federation.
The metaprebiotic STIMBIFIDE PLUS restores the individual intestinal microbiota, creating priority conditions for the proliferation of bifidobacteria, lactobacilli and E. coli, which, inhibiting the growth of pathogenic microbiota, displace it from the body. A significant increase in normobiota leads to an increase in colonization resistance of the gastrointestinal mucosa.
Metaprebiotic STIMBIFID PLUS is a further development and deep optimization of the prebiotic Stimbifid and consists of two components - prebiotic and metabiotic.
A narrowly targeted prebiotic component - natural fructooligosaccharides (FOS) and fructopolysaccharides (FPS) with an optimized ratio of short (GFn, n = 2-8) and long (GFn, n = 2-60) chains, which ensures the supply of bifidobacteria with exclusive nutrition along the entire length of the thick intestines.
The metabiotic component is calcium lactate. It is a powerful stimulator of growth and reproduction of normobiota (RF patents).
The combination in STIMBIFIDE PLUS of both metabiotics and prebiotics with different mechanisms of action contributes to:
- safe and effective restoration of one’s own (individual) intestinal microbiota, including while taking antibiotics;
- increasing colonization resistance of the gastrointestinal mucosa during infectious pathology;
- eradication of Helicobacter pylori;
- eliminating constipation ( effect of dietary fiber).
Side effects
The dietary supplement is considered harmless, which confirms the possibility of its administration to six-month-old children. But the manufacturer notes that in some cases its use may cause the development of local allergic reactions.
Overdose
No cases of overdose with Stimbifide have been reported.
Contraindications
The supplement is not prescribed to people with individual intolerance, nursing or pregnant patients. The drug should not be given to children under six months of age.
During pregnancy
Stimbifide is contraindicated during pregnancy and breastfeeding
Stimbifide should be taken with extreme caution during pregnancy. The same goes for the breastfeeding period.
Despite the fact that pregnancy and lactation are included in the list of contraindications, some doctors prescribe a dietary supplement to lactating and pregnant women if the expected benefits of its use outweigh the risks. In this case, the supplement is taken under the supervision of a doctor and its use is discontinued if illness occurs.
Dosage and methods of application:
Stimbifide Plus is available in the form of flat oval white tablets weighing 500 mg.
- adults and children over 14 years old: 2 tablets. 3 times a day with meals. Duration of treatment is 1 month. The number of courses is not limited;
- children over 3 years old: 1 tablet. 3 times a day with meals.
- ** In accordance with clinical data, for eradicating Helicobacter pylori is taking Stimbifida plus at a dose of 2 tablets 3 times a day for adults 30 minutes before meals for 28 days.
In order to adapt the gastrointestinal tract to fructosaccharides, it is possible to smoothly increase the daily dose to the recommended dose over 2–3 days. So, for example, for adults and children (from 14 years old) on the first and second day - 1 tablet. x 3 times a day, on the third – 2 tablets. x 3 times a day (full daily dosage). Likewise for other age groups.
Prebiotic component
The main therapeutic effects and properties of fructopolysaccharides and fructooligosaccharides, which are the prebiotic component of the unique Russian drug of the new generation - metaprebiotic STIMBIFID PLUS.
- For adults and children over 3 years old. Pleasant taste, good tolerance.
- A unique composition with a scientifically substantiated and optimized ratio of natural fructopols and fructooligosaccharides, which are exclusive nutrition for the intestinal microbiota’s own (individual) strains.
- Highly effective against intestinal dysbacteriosis (dysbiosis), acute intestinal infections.
- Unlike probiotic preparations containing live microorganisms, Stimbifid plus, a new generation metaprebiotic, restores the patient’s own (individual) microbiota. At the same time, the speed and safety of recovery is significantly higher. Highly effective for the prevention of intestinal microbiota disorders before, during, and after antibacterial therapy. Unlike lactulose, which is a product of the chemical industry, fructooligosaccharides have a natural base and higher efficiency (2-3 times based on equally effective doses).
- Stimulates intestinal motility, helps reduce constipation, and suppresses the formation of putrefactive substances in the intestines. Stabilizes the barrier properties of the intestinal mucosa.
- In children, it helps reduce cases of flatulence, diarrhea, intestinal diseases and fever. A clear positive effect on the well-being of children.
- Anti-inflammatory effect in chronic intestinal diseases.
- A pronounced effect on the immune system, leading to a decrease in the frequency of viral and microbial infections.
- Increases the phagocytic activity of liver cells, helping to protect it from infections.
- Prevention of osteoporosis by increasing calcium absorption by 20% and increasing bone mineral density, which is especially important for women during menopause and for the formation of bone tissue in children.
- Protective effect against intestinal cancer.
- The low energy value of fructo-oligosaccharides is 1.5 kcal/g (sugar has about 4 kcal/g). Unlike sugar, they do not turn into glycogen and do not increase blood glucose levels, which is very important for diabetics.
- Improving lipid metabolism, reducing cholesterol and triglycerides in the blood, and as a result, reducing the risk of cardiovascular diseases. Promotes less accumulation of adipose tissue.
- Reduces the level of ghrelin in the blood, a hormone that controls hunger. When using Stimbifida Plus, a feeling of fullness comes from less food, and the person does not overeat. Helps normalize body weight.
- Increases the effectiveness of vaccination of children and the elderly.
- Improving mental activity, reaction speed and memory.
Generalized data from foreign literature, as well as Russian studies, are presented.
Voluntary certification
Certificate No. ROSS RU.31411.04IVM0.01.N00086 dated May 28, 2018
Information on the effectiveness of dietary supplements is based on the Report of clinical studies and scientific data of the Scientific Society "Microbiota" dated April 16, 2018.
Note:
* In accordance with the Conclusion of the Scientific Society "Microbiota" (Chicherin I.Yu., Pogorelsky I.P., Lundovskikh I.A., Darmov I.V., Shabalina M.R., Podvolotsky A.S. Comparative experimental assessment of effectiveness modern probiotics, prebiotics, synbiotics and metabiotics in the correction of intestinal microbiocenosis disorders in animals with antibiotic-associated dysbiosis // Experimental and Clinical Gastroenterology, 2021, No. 7(131), pp. 106-120) among the most top drugs with similar indications for application and released for the period July 2021, the metaprebiotic Stimbifide Plus showed maximum effectiveness in terms of the rate of restoration of intestinal microbiota.
** In accordance with the “Reports on assessing the effectiveness and tolerability of the metaprebiotic Stimbifid plus in eradication therapy of patients with chronic antral gastritis associated with Helicobacter pylori in the acute phase” , carried out at the Department of Gastroenterology of the Federal State Budgetary Institution of Further Professional Education "Central State Medical Academy" UD of the President of the Russian Federation on time from 07/04/18 to 09/14/18 and from 12/10/18 to 03/29/19
Analogs
It is difficult to find analogues of Stimbifide, since the dietary supplement has unique pharmacological properties. However, if the drug is not suitable for you for one reason or another, the doctor will be able to find a replacement that has a similar effect.
Such drugs include such drugs as: Lactobacterin, Primadofilus, Linex, Bifidumbacterin, Bifiform and many others. The variety of forms of release of these drugs will help you find the drug that is right for you.
Key rules for preventing intestinal infection
What is dysbiosis?
The intestinal microflora of a healthy person consists of more than 90% anaerobic bifidobacteria and lactobacilli, which play a vital role not only in various stages of the digestive process, but also in the entire life activity of the human body. It is these representatives of the “useful” intestinal microflora that take an active part in the final digestion of food and the absorption of nutrients broken down by gastric juice into the blood, in the natural synthesis of neurotransmitters, proteins, B vitamins, in the metabolism of bile pigments and bile acids. In addition, “beneficial” bifidobacteria stimulate intestinal motility and provide protection for the intestinal mucosa from all kinds of infections (in combination with carbohydrates that are indigestible in the stomach and intestines, “useful” intestinal microflora forms a kind of enterosorbent that absorbs and removes a large amount of waste, toxins, and carcinogens from the body , and thereby prevents direct contact of all kinds of harmful substances with the intestinal mucosa).
By producing lactic and acetic acid as a result of their vital activity, bifidobacteria actively prevent the growth and development of pathogenic and opportunistic intestinal microflora, which often provokes the development of such a serious disease as intestinal cancer. Bifidobacteria that populate the epithelial surface of the intestine also have a beneficial effect on the functioning of the human immune system (by stimulating the functioning of the lymphoid apparatus and participating in the synthesis of immunoglobulins) and help improve lipid metabolism (by reducing cholesterol levels in the blood and stabilizing the level of phospholipids and lipoproteins circulating in the blood).
Poor nutrition, smoking, alcohol abuse, psycho-emotional stress, physical and mental overload, adverse effects of environmental factors, diseases of the gastrointestinal tract (cholecystitis, pancreatitis, hepatitis, gastritis, gastric and duodenal ulcers, dysentery, helminthiasis, salmonellosis), respiratory diseases, weakened immunity, as well as antibiotic treatment, the use of hormonal or chemotherapy contribute to a decrease in the number of beneficial bifidobacteria and lactobacilli and an increase in the populations of pathogenic and conditionally pathogenic intestinal microflora (including staphylococci, proteus, clostridia, Pseudomonas aeruginosa). This kind of change in the quantitative and qualitative composition of the intestinal microflora, manifested in a violation of the optimal balance of “beneficial” and pathogenic intestinal microflora, is called intestinal dysbiosis (dysbiosis).
The most common manifestations of intestinal dysbiosis are abdominal pain, dyspeptic symptoms (constipation, diarrhea, flatulence, nausea), increased fatigue, weakness, deterioration of complexion, weight loss or, conversely, weight gain.
As a result of the development of dysbiosis, the functioning of the digestive system and the detoxification function of the body are disrupted, the absorption of calcium and iron is impaired, the natural synthesis of vitamins is disrupted, immunity is reduced, and, accordingly, the human body’s susceptibility to infectious, allergic and oncological diseases significantly increases.
