TOP substitutes for Arcoxia: 12 best analogues

Prohibited during pregnancy

Prohibited during breastfeeding

Has restrictions for children

Has restrictions for older people

Has limitations for liver problems

Has limitations for kidney problems

The market for pharmacological agents that can cope with rheumatic pain syndrome is expanding quite often. Thanks to this, it is possible to choose a drug that will suit the patient according to three parameters at once - effectiveness, safety and price.

One of these medicines is the Swiss drug Arcoxia. The mechanism of action of the drug is based on the selective inhibition of cyclooxygenase-2, which is the most important link in the mechanism of prostaglandin formation.

Advantages of the drug Arcoxia

The latter, in turn, are the main pathological link in inflammatory processes. The peculiarity of Arcoxia is that, having pyrolytic and anti-inflammatory properties, the drug does not affect the condition of the blood system and the mucous membrane of the gastrointestinal tract.

Indications for the use of the drug are diseases of an inflammatory rheumatoid nature, as well as conditions accompanied by pain.

Arcoxia is not advisable to use in case of hypersensitivity to the components of the drug (drug), peptic ulcer of the stomach and duodenum, as well as symptoms of drug-induced asthma and allergic reactions in combination with other non-steroidal anti-inflammatory drugs. This medication is not prescribed for children under 18 years of age, pregnant and lactating women.

Despite this, the high cost of Arcoxia does not allow the drug to be used for systemic treatment and forces the doctor and patient to look for cheaper analogues.

Comparison of the effectiveness of Arcoxia and Kostarox

The effectiveness of Arcoxia is quite similar to Kostarox - this means that the ability of the medicinal substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Arcoxia is more pronounced, then using Kostarox even in large doses will not achieve this effect.

Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Arcoxia and Kostarox. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.

Substitutes for therapeutic effect

Arcoxia is an anti-inflammatory drug that affects the synthesis of arachidonic acid, therefore, when choosing its substitutes (for example, in case of intolerance to etoricoxib), the patient must be sure that a similar drug will have the same therapeutic effect.

This is especially important for people suffering from rheumatoid arthritis who need long-term use of drugs. For such people, individual sensitivity to the constituent components of the drug comes first. If the patient feels that the treatment does not bring a positive result or even causes a worsening of the condition, you should contact your doctor.

Dilaksa

Dilaxa is part of the coxibs group. The main active ingredient, celecoxib, has the ability to inhibit COX-2 and partially COX-1. This medication requires a higher dosage to achieve a therapeutic effect. Also, the time to reach the maximum concentration of the substance in the blood plasma is longer than that of drugs with etherocoxib - 2-3 hours versus 1.5 hours, respectively.

It is important to note that in addition to PGE-2, Dilaxa retains sodium in the body, which may be accompanied by the appearance of edema in patients even without impaired renal function.

This side effect can be corrected with the help of diuretics, but nevertheless, for patients with chronic renal failure and diseases of the cardiovascular system, the drug must be prescribed with caution.

In body tissues, the concentration of Dilaxa depends on the state of hepatocytes and the metabolic function of the liver, therefore, for patients with moderate and severe liver failure, it is necessary to take into account that the total concentration of the substance is 2 times greater in comparison with healthy people. Dilaxa is prescribed for the treatment of:

• osteoarthritis;
• rheumatoid arthritis;
• pain syndrome of various etiologies.

Osteoarthritis

The drug is contraindicated for people with intolerance to the active substance, gastric and duodenal ulcers, inflammatory bowel diseases in the acute stage, heart failure, hemorrhagic stroke, as well as children, pregnant women and women who are breastfeeding.

Artrofoon (Artrophon)

Artrophoon differs from all of the above drugs not only in its drug group, but also in its mechanism of action. Thus, belonging to the group of anti-inflammatory immunomodulatory drugs, the drug has an anti-inflammatory and analgesic effect due to a decrease in the synthesis of cytokines, increasing the production of Tumor Necrosis Factor.

Mechanism of action of Arthrofoon

The latter, in turn, allows the drug to be used for the treatment of:

• rheumatoid arthritis:
• osteoarthritis;
• osteochondrosis;
• nonspecific ulcerative colitis.

A special feature of the drug is the possibility of using it both in monotherapy and in combination with non-steroidal anti-inflammatory drugs.

Also, Artrofoon has no pathological drug interactions, a small list of contraindications and side effects. It is necessary to take into account the fact that while taking drugs, an increase in pain and inflammatory reaction may occur, but this is a short-term condition that does not require a revision of the dosage of the drug. The drug is produced by the Materia Medica Holding company in the Russian Federation.

Celecoxib

This representative of the coxib class is the cheapest analogue among other drugs similar to Arcoxia. However, it is not inferior to them in its therapeutic properties. Celecoxib primarily inhibits COX-2 and the formation of PGE-2, which makes it an effective treatment for rheumatic and other inflammatory diseases of the human musculoskeletal system, as well as psoriatic arthritis.

Celecoxib

It must be remembered that Celecoxib can inhibit the work of diuretics and promotes water retention in the body, therefore it is not suitable for people with severe edema syndrome, as well as heart failure. Also, the drug is completely contraindicated for people who have a history of manifestations of the “aspirin triad”:

• intolerance to salicylates;
• nasal polyposis;
• bronchial asthma while taking aspirin.

Pregnant women should take Celecoxib with great caution, as it can cause disturbances in the process of fusion of the fetal cardiac septum. In this case, the choice of drugs is based on the benefit/risk principle.

Comparison of safety of Arcoxia and Costarox

The safety of a drug includes many factors.

At the same time, in Arcoxia it is quite similar to Kostarox. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing metabolism in Arcoxia, as well as in Kostarox, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Arcoxia does not have any risks when used, just like Kostarox.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Arcoxia and Kostarox.

Prices for the drug and its analogues

Below are the average prices in the Russian Federation for Arcoxia analogues.

Comparison of addiction between Arcoxia and Kostarox

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values ​​of such parameters as “syndrome o” in Arcoxia is quite similar to the similar values ​​in Kostarox. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, in Arkoxia the meaning of the “syndrome” is quite small, however, the same as in Kostarox.

Comparison of side effects of Arcoxia and Kostarox

Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.

Arcoxia has almost the same level of adverse events as Costarox. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Arcoxia are similar to Kostarox: how quickly the body recovers after taking it and whether it recovers at all.

Comparison of ease of use of Arcoxia and Kostarox

This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.

The ease of use of Arcoxia is approximately the same as that of Kostarox. However, they are not convenient enough to use.

The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.

Last update date: 2021-01-10 10:02:22

The cheapest similar products

For a patient who is looking for Arcoxia analogues, it is important that they are not only cheaper, but also correspond to the original release form - soluble powders, capsules, ointments or tablets. Tablet forms have many advantages over others, especially if systemic and long-term use of drugs is necessary.

The main features of such drugs are their safety (no need for injections) and high bioavailability, since the membranous membrane protects the active substance from destruction before entering the gastrointestinal tract.

Celebrex

A German drug that belongs to the coxibs group. The effect of the drug is due to its effect on cyclooxygenase-2 and further inhibition of the formation of E2 prostaglandins. Unlike Arcoxia, Celebrex is produced not in tablets, but in capsules, which allows you to fit a larger amount of drugs into one unit.

Features of the drug use

Also, the capsule shell protects its contents from premature dissolution, delivering the substance directly to the duodenum for further absorption. The drug is prescribed to patients with rheumatoid arthritis and ankylosing spondylitis, and is also used in the treatment of primary dysmenorrhea.

Diclofenac

Diclofenac is a derivative of phenylacetic acid. Unlike Arcoxia, the drug acts on all three cyclooxygenases and other processes in the synthesis of arachidonic acid, thereby disrupting the formation of prostaglandins E2 and E2-alpha, leukotrienes, thromboxane and other lysosomal enzymes.

The drug has an anti-inflammatory, pyrolytic, analgesic effect, but its main application is in rheumatology. The low cost of Diclofenac allows it to be used as a systemic therapy for rheumatoid arthritis, gout, bursitis, as well as post-traumatic pain syndrome. The drug is manufactured in India by Shreya Life Sciences.

Nimesulide

Nimesulide has a more pronounced analgesic effect compared to Arcoxia. It has a reversible inhibition of prostaglandin E2 not only at the site of inflammation, but also in the nociceptive system, reduces the conductivity of nerve fibers and helps reduce pain sensitivity.

Basic mechanisms of action of Nimesulide

In addition, there is a decrease in the synthesis of cytokinins, which is accompanied by a rapid anti-inflammatory reaction. Another feature of Nimesulide is its high bioavailability in children and the elderly, since the pharmacokinetics are practically independent of the condition of the kidneys and the creatinine index.