Bromhexine 8 Berlin-Chemie: instructions for use, price and reviews

Pharmacodynamics and pharmacokinetics

Bromhexine 8 Berlin-Chemie is characterized by secretolytic (mucolytic) and secretomotor (expectorant) effectiveness, and also has a weak antitussive effect. Taking the drug reduces the viscosity of bronchial secretions , stimulates ciliated epithelial , increases the amount of sputum and promotes its rapid discharge. In addition, the drug activates the production of endogenous surfactant the alveolar epithelium during respiration . The maximum effectiveness of therapy is observed on days 2-5 from the start of taking the drug.

When taken orally (inside) for 30 minutes, almost complete absorption of bromhexine (99%) in the gastrointestinal tract is observed. The bioavailability of the drug is at the level of 80%. Bromhexine is 99% bound to plasma proteins It has the ability to penetrate the blood-brain and placental barriers, as well as into the milk of a nursing mother. Hepatic metabolic transformations occur through oxidation and demethylation , up to the formation of ambroxol . The average T1/2 due to slow reverse tissue diffusion is 15 hours. Excretion is carried out by the kidneys (urine) in the form of metabolites . Repeated use leads to the accumulation of the drug in the human body. With chronic renal failure of metabolic products is impaired.

Use of the drug for alcoholism

Alcoholism is the state of alcohol dependence, leading to the formation of inflammatory diseases of the abdominal organs. Gastritis and colitis occur, which then turn into ulcers. The greater impact falls on the liver tissue.

Hepatocytes are destroyed and an inflammatory reaction occurs. Both conditions are not contraindications for taking the medicine, but against the background of addiction, its use is not recommended.

If prolonged use of the drug can cause an increase in liver enzymes, then alcoholism forms hepatitis. Due to the increased impact on the organ, the stage of fibrosis occurs faster.

Indications for use

The use of Bromhexine Berlin-Chemie is indicated in the case of bronchopulmonary diseases of a chronic or acute course, accompanied by the production of viscous sputum:

pneumoconiosis;
bronchial asthma;
cystic fibrosis;
pneumonia;
emphysema ;
tracheobronchitis;
bronchiectasis;
obstructive bronchitis;
tuberculosis.

Contraindications

Taking bromhexine is absolutely contraindicated if:

breastfeeding;
personal hypersensitivity to bromhexine and/or other components of the drug;
sugar intolerance;
pregnancy in the first trimester;
exacerbation of peptic ulcer ;
under the age of 6 years.

Relative contraindications are:

/ liver pathologies ;
tendency to gastrointestinal bleeding ;
disturbances of bronchial motility with excessive concentration of secretions.

When to take with caution

The drug should be prescribed by the attending physician, taking into account the characteristics of the patient. These include:

liver or kidney diseases, gastrointestinal tract;
diabetes mellitus type 1 or 2;
periodic internal bleeding in the intestines or stomach;
diseases of the respiratory system with the accumulation of large amounts of sputum

The use of the drug in the second and third trimester of pregnancy should be under the supervision of the attending physician. If there is a need to use the medicine during breastfeeding, it is necessary to weigh the benefits and possible risks. The components in the product can pass into breast milk and enter the baby’s body with it.

Side effects

As a rule, treatment with bromhexine is tolerated without any negative effects.

In some rare cases, the following were observed: nausea / vomiting , dyspeptic , dizziness , exacerbations of peptic ulcers , shortness , headaches , chills, fever, as well as allergic manifestations (skin rash , swelling , rhinitis ).

anaphylactic shock may occur .

Sometimes an increase in the activity of liver transaminases .

If any allergic , you must stop taking bromhexine and inform your doctor about the observed symptoms.

Bromhexine and beer

Doctors do not advise mixing the mucolytic drug Bromhexine even with such a weak alcoholic drink as beer. In most cases, the body reacts negatively to such a symbiosis, causing nausea, vomiting, indigestion and constipation.

The drug is metabolized through the liver, just like beer, so the toxic load on the liver increases. If you constantly mix the medicine with an alcoholic drink, the condition of the filter organ will worsen, and there is a risk of developing cirrhosis and hepatitis.

The kidneys remove the drug and alcohol, but alcohol is always a priority. The paired organ, in order to quickly cleanse the body, can remove the active substance before processing it.

Instructions for use Bromhexine 8 Berlin-Chemie

The instructions for Bromhexine Berlin-Chemie include oral (oral) administration of tablets (dragées). The tablets should be taken whole immediately after meals and washed down with 200-250 ml of water.

A single dosage of B romhexine for patients over 14 years of age is 1-2 tablets (dragées) taken three times per 24 hours.

For body weights up to 50 kilograms, as well as at the age of 6-14 years, a single dose is equal to 1 tablet (dragée) 8 mg, with a similar frequency of doses per day.

In case of existing / liver pathologies, it may be necessary to reduce the recommended dosage or reduce the number of doses, which requires consultation with a doctor.

The duration of prescribed therapy is determined by the attending physician and depends on the diagnosed disease and the severity of its course. If treatment is necessary for more than 4-5 days, you should consult a doctor.

For the treatment of children from 2 to 6 years old, the Berlin-Chemie company produces bromhexine syrup with a dosage of 4 mg/5 ml, which is taken three times a day, 5 ml.

The most dangerous combinations and consequences

The combination of alcohol and chemical-based drugs can lead to serious disorders in the body, and in some cases to fatal consequences.

List of medications and their side effects in combination with alcohol:

Name of group, drug	Negative results of interaction
Neuroleptics (tranquilizers, anticonvulsants, hypnotics)	Severe intoxication, up to cerebral coma
CNS stimulants (Theophedrine, Ephedrine, Caffeine)	Rapid increase in blood pressure, hypertensive crisis
Antihypertensives (Captofrin, Enalapril, Enap-N), diuretics (Indapamide, Furosemide)	Sudden drop in pressure, collapse
Analgesics, anti-inflammatory	Increased toxic substances in the blood, general poisoning of the body
Acetylsalicylic acid (Aspirin)	Acute gastritis, perforation of gastric ulcer and 12-PC
Paracetamol	Toxic liver damage
Hypoglycemic (Glibenclamide, Glipizide, Metformin, Phenformin), insulin	A sharp decrease in blood sugar levels, hypoglycemic coma

Sources

https://24infomed.ru/populyarnye-stati/alkogol-i-bromgeksin.html
https://mylogovo.ru/mozhno-li-pit-bromgeksin-posle-alkogolja/
https://drugs.medelement.com/drug/%D0%B1%D1%80%D0%BE%D0%BC%D0%B3%D0%B5%D0%BA%D1%81%D0%B8%D0 %BD-8-%D0%B1%D0%B5%D1%80%D0%BB%D0%B8%D0%BD-%D1%85%D0%B5%D0%BC%D0%B8-%D0% B8%D0%BD%D1%81%D1%82%D1%80%D1%83%D0%BA%D1%86%D0%B8%D1%8F/250049821477650954?instruction_lang=RU
https://www.polismed.com/articles-bromgeksin-instrukcija-po-preparatu-primenenie-formy-vypuska.html
https://MyWeak.ru/alkogolizm/lekarstva/bromgeksin-sovmestimost.html

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Overdose

No life-threatening adverse effects were observed when taking excessive doses of bromhexine Possible symptoms of overdose were limited to nausea / vomiting , diarrhea and other dyspeptic symptoms.

The recommended treatment is to induce vomiting and cleanse the gastrointestinal tract (if an overdose is detected in the first 60-120 minutes). Subsequent therapy should be appropriate to the observed symptoms.

Consequences of drinking alcohol

If a person drinks alcohol once during treatment with a mucolytic, no serious adverse reactions will occur.

But if you use the medicine throughout the entire therapy, the following consequences occur:

nausea, vomiting, due to which all the medicine taken is evacuated from the digestive tract, so there is no therapeutic effect;
allergic skin reactions, manifested in the form of a rash, but they disappear after stopping the use of both substances;
high risk of spasm in the bronchi due to the accumulation of exudate, which can lead to a severe attack of suffocation and increased coughing;
alcohol leads to increased kidney function, so fluid is removed from the body faster, dehydration occurs, which thickens the sputum even more;
with constant violation of the rule, gastritis is formed, which transforms into a stomach or duodenal ulcer;
if the patient had inflammation of the gastrointestinal mucosa at the time of treatment, the risk of bleeding increases.

To clarify the possibility of consequences, consult a therapist about the joint use of substances.

Interaction

The drug is not compatible with alkaline solutions .

Due to the difficulty of removing liquefied sputum , the combined use of the drug with drugs that have a depressing effect on the cough center (including codeine-containing drugs ) should be avoided.

In the first 4-5 days of antibiotic therapy using Amoxicillin , Erythromycin , Oxytetracycline , Cephalexin and Ampicillin and simultaneous administration of Bromhexine bronchial secretions may increase .

“Dose” of alcohol and types of alcoholic drinks

The concept of “alcohol” includes various alcoholic beverages such as beer, champagne, red or white wine, vodka or brandy. To calculate the ethyl alcohol taken, a conditional value is used, which is called the “dose”. Dose is the average indicator of an alcoholic drink consumed, corresponding to the onset of an average degree of intoxication for a person weighing 60 kg. For comparison, 1 dose of beer corresponds to 355 ml of drink (5% ethanol by volume), table wine - 150 ml (12% ethanol by volume), port wine - 100 ml (17% ethanol by volume) and vodka or brandy - 45 ml (40 % vol. ethanol). Clinical observations indicate that the absence of the effect of alcohol on the body is usually observed when its concentration in the blood plasma reaches 0.5-3.0‰.

special instructions

During therapy, you need to consume an increased amount of fluid, which helps to increase the secretolytic effectiveness of Bromhexine .

If bronchial motility or if there is a large volume of sputum , caution should be exercised, as these conditions contribute to the retention of secretions .

In case of severe kidney pathologies, Bromhexine .

In order to facilitate the removal of bronchial secretions , it is recommended in childhood to combine Bromhexine with vibration massage of the chest or postural drainage .

In what cases is it recommended to take Bromhexine?

The drug taken orally has a pronounced secretolytic and secretomotor effect on the mucous membrane of the bronchial tract. Accordingly, as a result of the implementation of this effect, the intensity of bronchial secretion increases significantly, the viscosity of mucus (sputum) decreases and the activity of the cilia of the ciliated epithelium increases. All these factors together contribute to the acceleration of the movement of mucus (phlegm) through the respiratory tract.

Please note that Bromhexine is effective only for dry cough. Accordingly, it makes sense to use it (like all other mucolytics) in the initial stage of the disease. If the patient is already expelling large quantities of sputum, then there is no point in enhancing the mucociliary effect - with a high probability this can lead to the syndrome of “flooding” the bronchial tree with sputum, and will worsen the patient’s condition.

Pathologies (diseases) for which it is recommended to take bromhexine include infections of the upper, lower and middle parts of the respiratory tract (bronchitis, laryngitis, pneumonia). Please note that even with the mildest viral infection, Bromhexine is used only in complex therapy, because it does not directly affect the microorganism that caused the disease. This drug only alleviates the patient’s condition by helping to remove phlegm.