Veins are blood vessels that carry blood to the heart. In turn, blood is collected in the veins from capillaries. With healthy arteries, the circulatory system works stably. But what happens if problems arise with the veins? Swelling, pain in the legs, slight numbness, goosebumps, heaviness, impaired sensitivity in the form of paresthesia, convulsions, trophic disorders. These signs, repeated day after day, are most likely recognized by the doctor as venous insufficiency.
Excess body weight can lead to varicose veins
Pharmacodynamics, pharmacokinetics
The medicine has a venotonic, angioprotective effect. After its use, venostasis, capillary permeability, and vein distensibility decrease.
In addition, taking the medicine helps:
- Improving microcirculation
- Lymphatic drainage
- Increased tone of venous walls
- Reducing the interaction of leukocytes and endothelium
Basically, active substances are excreted through the intestines, a small part of them through the kidneys.
Analogues of the drug Detralex
For problems with veins and varicose veins, it is possible to use Detralex analogues. They can have a similar therapeutic effect, but have their own contraindications, dosages and possible side effects. Be sure to consult a specialist!
So the pharmaceutical market offers us the following analogues of Detralex:
Venozol
The main active ingredients, like Detralex, are diosmin and hesperidin. Pharmacological action is similar to Detralex. Release form: tablets, gel and cream.
Vasocket
The active substance (diosmin) reduces the distensibility and increases the tone of the veins, thereby preventing the appearance of edema. Available in tablet form.
Antistax
Bioflavonoid drug belongs to the group of venotonic drugs. Available in tablet form.
Troxevasin
Produced under the trade names Venoruton, Troxerutin. Improves the condition of the walls of blood vessels and has an anti-edematous effect. Main forms of release: capsules, gel for topical use, solution for injection in ampoules.
Analogues of the drug Detralex
Anavenol
Combined venoprotective drug. Available in tablet form. Side effects: bleeding, dizziness, nausea. Contraindicated for children under 15 years of age.
Venoruton
Angioprotective drug. The active ingredient is hydroxyethylrutoside. Release form: tablets and gel for external use. Possible use in the second and third trimesters of pregnancy.
Ginkor fort
Venotonic and venoprotective drug It contains a standardized extract of ginkgo biloba, heptaminol hydrochloride and troxerutin. Available in the form of capsules and gel for external use. In case of overdose, blood pressure may increase. According to indications, the drug can be prescribed in the second and third trimesters of pregnancy. Contraindicated in hyperthyroidism and concomitant use of MAO inhibitors.
Detralex or Venarus?
Venarus is a generic drug. That is, it is based on the same active ingredients (diosmin and hesperidin), but the original drug (Detralex) always contains components of a higher degree of purification. Therefore, its effectiveness is higher and its tolerability is better. In addition, Venarus is characterized by lower bioavailability and more often provokes adverse reactions in the body. The drug is also contraindicated during lactation. The pharmacological action is similar to the drug Detralex. There is no fundamental difference between them. Recommendations for taking medications for varicose veins and hemorrhoids are identical.
Detralex or Phlebodia?
The active ingredient of the drug Phlebodia 600 is diosmin. But its concentration in Detralex is 450 mg/tablet (plus its enhancing hesperidin 50 mg/tablet), and Phlebodia 600 is available in the form of tablets with a diosmin concentration of 600 mg/tablet.
The medicine has a therapeutic effect similar to Detralex. It also increases the tone of the venous wall, improves blood flow, and normalizes the permeability of vascular walls.
Nevertheless, Detralex is absorbed into the body faster than its analogue, and its concentration in the blood plasma reaches its maximum after three to four hours.
In what cases are Detralex tablets prescribed?
The use of Detralex is advisable for venolymphatic insufficiency of the legs, in which the following occurs:
- pain and swelling
- heaviness in the legs
- convulsive manifestations
- trophic disorders
The pharmaceutical agent is prescribed for the treatment of acute hemorrhoidal attack.
Important to know: Detralex for hemorrhoids and varicose veins is used as a symptomatic drug, most often used as a complex treatment.
Side effects
When taking the drug Detralex, in rare cases, the following adverse reactions may develop:
- from the gastrointestinal tract: dyspepsia, diarrhea, nausea, vomiting, colitis;
- from the central nervous system: headache, dizziness, general malaise;
- from the skin: urticaria, itching, rash, isolated swelling of the face, eyelids, lips, angioedema.
If any side effects occur, you should consult your doctor and adjust your treatment.
Detralex, how much to drink
It is wise to take Detralex only as prescribed by a doctor; self-medication can lead to undesirable consequences. Based on the complexity of the situation and the course of the disease, the doctor must determine the duration of the therapeutic course. It is useful to know that even taking several tablets can lead to drug addiction.
If necessary, the doctor may prescribe a second course of medication.
For chronic hemorrhoids, tablets are usually taken for 2-3 months.
Contraindications and adverse reactions
The medicine has practically no contraindications. You should avoid taking it if you are allergic to any of the ingredients.
Negative effects from taking appear in extremely rare cases. They usually present with nausea and stomach upset. Sometimes dizziness, headache, and deterioration in general health may occur. An allergy may appear in the form of a skin rash.
To date, there have been no cases of drug overdose. In the chronic stage of the disease, experts usually advise taking the medicine in courses of 2-3 months. In case of acute form, take in weekly courses.
If after this time the symptoms have not disappeared, the patient should schedule an examination with a specialist.
Instructions for use
For varicose veins, the doctor may prescribe 2 tablets per day. The medicine should be taken one at a time, during lunch and dinner.
In the acute stage of hemorrhoids, doctors prescribe 6 tons of tablets per day in the first 4 days of treatment, and in the next 3 days you need to drink 4 tablets every day. The daily dosage must be divided into several doses; the medication should be taken during meals. After taking the medicine for a week, the dose is reduced by 2 times, taken only once a day.
Medicine Detralex
Detralex is produced by the French company Servier, whose production complex is located, among other things, in Russia.
The main principle of the company producing Detralex is environmental friendliness, naturalness and safety. Therefore, all Servier products are a guarantee of high quality. Detralex is no exception. THIS IS INTERESTING: one of the components of Detralex - hesperidin - is extracted from the peel of unripe oranges. Moreover, the choice of unripe fruits is approached with special care - their size should not exceed 2.5 cm in diameter. Because the smaller the fruit, the more valuable substances it contains. The main countries for orange production are Mexico, Egypt, China and Morocco. First, the orange peels are dried and crushed. This is how the basis for Detralex is obtained - a complex of flavonoids or a flavonoid fraction, which is then sent for refinement and production of the drug we are familiar with.
Can Detralex be used by pregnant women?
In the first trimester of pregnancy, the medicine can be prescribed only in exceptional cases when the risk of blood clots is high.
In other situations, according to the doctor’s decision, the drug is prescribed after the 20th week of pregnancy.
Detralex is also prescribed to pregnant women for hemorrhoids and varicose veins; it helps cope well with swelling of the legs.
Obstetricians and gynecologists are of the opinion that the drug does not have a negative effect on the body of the woman and the fetus. Therefore, if necessary, they consider it advisable to use it.
Detrolex reduces the risk of developing thrombophlebitis or exacerbation of hemorrhoids in pregnant women.
Chronic venous insufficiency
Chronic venous insufficiency is a common peripheral vascular disease that occurs as a result of impaired blood flow through the veins of the lower extremities and changes in the permeability of the vascular wall. Most often, venous insufficiency develops in women. The disease occurs when the valves that close the veins are unable to prevent blood from flowing back due to increased pressure on them. As a result, this leads to stretching of the walls of the venous vessels. The permeability of the vascular wall for blood and plasma proteins increases, swelling and compaction of adjacent tissues appear. Where small vessels are compressed, areas of ischemia (insufficient blood supply with oxygen) occur, which contributes to the formation of trophic ulcers.
The main risk factors for the development of chronic venous insufficiency include:
- weakness of the muscular wall of the veins (hereditary);
- overweight and obesity;
- pregnancy and childbirth;
- long-term constant work in a standing or sitting position, with limited movement (cooks, office workers, surgeons, etc.);
- chronic constipation;
- fluctuations in hormonal levels in women (contraception with hormonal drugs, hormonal treatment during menopause, etc.);
- wearing tight underwear and clothing, corsets.
The following stages of development of varicose veins are distinguished:
- Stage 0 – no major symptoms upon examination.
- Stage I - “morning fatigue” of the legs, complaints of intermittent swelling in the evenings (disappears in the morning).
- Stage II – persistent swelling, skin pigmentation disorders; some areas of the skin become thicker, the skin above them cannot be folded (lipodermatosclerosis), redness appears on the skin, accompanied by itching and weeping (eczema).
- Stage III – the formation of trophic ulcers (active or healed), difficult to treat with medication.
The disease is accompanied by pain of varying intensity and the presence of evening cramps. In the treatment of varicose veins in the early stages, compression with elastic bandages and compression hosiery, physiotherapy and therapy in a sanatorium are used.
Interaction
No special studies have been conducted to identify the interaction of Detralex with other drugs. However, to date there are no reports of negative interactions between the drugs and other medications.
Special studies regarding drug and other forms of drug interaction have not been conducted. However, given the extensive experience of post-registration use of Detralex, to date there are no statements about its adverse interaction with other drugs.
Detralex during pregnancy and lactation
Detralex is not recommended for pregnant women
The use of Detralex by pregnant women and children during breastfeeding is not recommended due to insufficient research and clinical data. There is no information on the occurrence of side effects in pregnant women, nor has there been any information recorded on the ability of the active ingredients - diosmin and hesperidin - to pass into breast milk during breastfeeding, as well as in children during breastfeeding.
Composition of Detralex
The main active ingredients of Detralex are diosmin 900 mg (90%) and hesperidin 100 mg (10%). As well as excipients to ensure better absorption of active substances and their transportation to their destination, that is, to the vascular system. Both active ingredients of Detralex are flavonoids, which are obtained from orange peel. Detralex is a semi-synthetic drug with proven effectiveness and numerous clinical studies.
An important component in the production of Detralex is the process of micronization (grinding) of the active substance. This is an expensive stage of production. Few enterprises include it in the drug manufacturing cycle. But it is this procedure that minimizes the effect of the drug on the gastrointestinal tract and promotes good bioavailability, that is, absorption in the body. Thus, the good tolerability of Detralex is one of its main advantages over other phlebotonics.
Release form and dosage of Detralex
Detralex tablets
The tablet form of the drug Detralek is available in dosages of 500 mg and 1000 mg.
The number of tablets in packages is 30 and 60 pcs. For the treatment and prevention of varicose veins for 1 month and 3 months, respectively (1 tablet 1 time per day). The drug is also available in a package of 18 tablets at a dosage of 1000 mg - for the treatment of hemorrhoids. Detralex suspension
Detralex suspension is ready for use, easy to swallow, does not require dilution or washing down with water - you just need to squeeze the suspension from the bag directly into your mouth/spoon and swallow. This form is perfect for people leading an active lifestyle, for those who are often on the road and flying. 1 sachet contains 1000 mg of active ingredient. There are 30 sachets in one package.
Detragel
Detralex gel (Detragel) for topical use in complex therapy for the treatment and prevention of varicose veins. As an independent remedy, it can be used for fatigue and heaviness in the legs, as well as pain, swelling, contusions and bruises. Does not leave marks on clothes and skin. In the production of the gel, an innovative substance delivery system is used, due to which the active substances quickly penetrate the body. Can be used either alone or in combination with the venotonic Detralex in the form of tablets or suspension. Available in volumes of 40 mg and 80 mg.
Indications for Detralex
The drug Detralex is indicated for eliminating and alleviating the symptoms of venous diseases of varying severity. A course of Detralex eliminates the symptoms of venous-lymphatic insufficiency:
- pain and discomfort in the limbs;
- cramps in the legs and feet;
- feeling of heaviness and fullness;
- "tired" legs.
It also effectively fights the visible manifestations of venous-lymphatic insufficiency:
- swelling;
- trophic changes in the skin and subcutaneous tissue;
- venous trophic ulcers.
- spider veins
Treatment of varicose veins
Regimen for taking Detralex for varicose veins
In order to prevent swelling and heaviness, varicose veins and venous insufficiency, if there is a risk (sedentary/standing work, increased stress), the recommended dose is 1 tablet per day for 3-6 months. After a break, the course of the drug can be repeated. Monotherapy using only detragel is also suitable as a preventive measure.
Treatment of hemorrhoids
Hemorrhoids are the result of impaired blood circulation and an inflammatory process in the choroid plexus of the rectum, which is accompanied by thrombosis, varicose veins, as well as sclerosis of the veins with frequent complications in the form of bleeding and pain during defecation. Detralex for hemorrhoids is prescribed in a short course, lasting 7 days.
Dosage regimen for hemorrhoids
Contraindications
The drug Detralex has one main contraindication - individual intolerance to the active substances and components of the drug. In rare cases, during clinical studies, side effects such as nausea, vomiting and stool upset, allergic reactions in the form of urticaria and itching were observed (therefore, persons with a tendency to allergies of various origins should take the drug with caution), headaches and weakness.
Before you start taking Detralex orally, you should notify your doctor about all the existing characteristics of your body in order to draw up the most successful treatment regimen with Detralex.
