Types of local anesthesia: ointment, gel, cream, spray

Types of local anesthesia: ointment, gel, cream, spray

Bibliography

1 GRLS, r/u LP-004175 dated 03/03/2017

2 Certificate GMP-0036-000221/18

3 Greveling K, Prens EP, Ten Bosch N, van Doorn MB. Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials. Br J Dermatol. 2021 Jul 5. doi:10.1111/bjd.14848 Hernandez E.;

4 J. Cassuto, R. Sinclair, M. Bonderovic, Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand 2006; 50; 265-282]

5 Based on IQVIA report March 2021 - September 2021

6 Russian medical journal. Zhigultsova T.I., Parkaeva L.V., Ilyina E.E., Vissarionov V.A.: “Experience of using 5% Emla cream in the practice of dermatocosmetologists”

7 Instructions for use of the medicinal product for medical use Acriol Pro

8 T.N. Calvey, N.E. Williams. Pharmacology for anesthesiologists. Publishing house Binom, Moscow, 2007, 119-128

9 Based on the report “Anesthetics in injection cosmetology for 2016” Vademecum Analytical Center for sales volume.

10 T.I. Zhigultsova, Ph.D. L.V. Parkaeva, E.E. Ilyina, professor V.A. Vissarionov: “Experience of using 5% Emla cream in the practice of dermatocosmetologists” Cosmetology and plastic surgery. Vol. 16, No. 9, 2008

11 On the Russian market there are so-called cosmetic products containing lidocaine and not registered as medicines

12 Cling film can be used as an occlusive dressing

13 Drug Release Studies on an Oil-Water Emulsion Based on a Eutectic Mixture of Lidocaine and Prilocaine as the Dispersed Phase

14 Federal Law-61 “On the Circulation of Medicines” dated April 12, 2010, Federal Law-323 “On the Fundamentals of Protecting the Health of Citizens in the Russian Federation” dated November 21, 2011 and Federal Law-532 “On Amendments to Certain Legislative Acts of the Russian Federation Regarding Counteraction to Trafficking falsified, counterfeit, substandard and unregistered medicines, medical devices and counterfeit dietary supplements" dated December 31, 2014.

15 Federal Law-532, Technical Regulations of the Customs Union on the safety of perfumery and cosmetic products, Federal Law 61, Federal Law 532, Criminal Code of the Russian Federation, Art. 235, 238, 227

16 V.V. Osipova.MMA named after. I.M. Sechenov. Psychological aspects of pain. Lecture. №1/2010

17 According to GMP News. Analysis of the market for local anesthetics used in cosmetic injections in 2021.

18 One type of occlusive dressing, namely: bandage, cling film, adhesive tape or rubberized fabric

19 The combination of lidocaine and prilocaine in concentrations above 0.5-2% has bactericidal and antiviral properties. In Akriol Pro the concentration is 5%.

20 A.A. Stepanov, G.V. Yatsyk, L.S. Namazova Method of preventing pain in young children during vaccination // Into the practice of pediatricians - 09.14.2006 -

21 N.V. Klipinina, RMJ, Some features of the perception and experience of pain by children: a psychologist’s view, reprint. 2007.1-7

22 E.A. Ranneva. The use of EMLA® cream in the complex correction of cosmetic imperfections. Experimental and clinical dermatocosmetology 2010, No. 2: 48-53.

23 Gonzalez S. Evaluation of Topical Anesthetics by Laser-Induced Sensation. Lasers in Surgery and Medicine 23:167–171(1998));

24 V.G. Lebedyuk et al. Anesthesia in dermatocosmetology. Experimental and clinical dermatocosmetology, 2010 No. 5

25 Meltem F. Söyleva Nilüfer Koçaka Bahar Kuvakia Seyhan B. Özkanb Erkin Ki˙rb; Anesthesia with Cream for Botulinum A Toxin Injection into Eyelids. Ophthalmologica 2002;216:355–358

26 E.V. Matuszewska and authors. Topical local anesthetics in cosmetology. Clinical Dermatology and Venereology. 03.2017 pp. 89-96

27 Therapeutics and Clinical Risk Management 2006:2(1) 99 – 113

28 F. Michael Ferrante, Timothy R. Wade Bopcore Postoperative Pain. Management. Per. from English/Ed. M.: Medicine, 1998.- 640 pp., p. 243

29 Lakhin R.E. Local anesthetics. Department of Anesthesiology and Reanimatology of the Military Medical Academy named after. S.M.Kirova, St. Petersburg, 2013, Committee on Ultrasound Technologies of the All-Russian public organization “Federation of Anesthesiologists and Resuscitators.” Clinical guidelines “Intensive therapy for systemic toxicity with local anesthetics. Moscow - St. Petersburg 2015 Page. 10 https://www.far.org.ru/recomendation

30 Wetter DA et al. J American Acad. Dermatol. 2010;63(5):789-98

31 https://www.1nep.ru/articles/issledovanie-sostava-populyarnykh-mestnykh-anestetikov/

32 ORDER OF THE MINISTRY OF HEALTH OF THE RUSSIA dated 08.10.2015 No. 707n

33 Davydov O.S. Peripheral and central mechanisms of the transition of acute pain to chronic pain and the possible role of cyclooxygenase 2 inhibition in the prevention of chronic pain syndrome. Neurology, neuropsychiatry, psychosomatics. 2016;8(2):10-16.

34 J. ALASTAIR CARRUTHERS, MD, JEAN DA CARRUTHERS, MD. Safety of Lidocaine 15% and Prilocaine 5% Topical Ointment Used as Local Anesthesia for Intense Pulsed Light Treatment. Dermatologic Surgery 2010;36:1130–1137

35 Ya-Xian et al. The number of cells in the stratum corneum of normal skin depending on the anatomical location on the body, age, gender and physical parameters Archives Dermatol Res 1999; 291:555–559.

36 J. Morgan, Magid S. Michael. Clinical anesthesiology, Book 1. Binomial. Moscow St. Petersburg, 2001

37 Arendt-Nielsen L, Bjerring P, Nielsen J. Acta Derm Venereol 1990;70:314-318

38 Belarusian State Medical University. 2nd Department of Therapeutic Dentistry. Therapeutic dentistry. Part 1. Ed. A.G. Tretyakovich, L.G. Borisenko.

39 Dermatol Surg 1999;25:950-954

40 K. Greveling et al. Br J Dermatol 176(1), 81-86. 2021 Dec 10

41 Juhlin and Evers Adv Dermatol 1990;5:75-92

42 Arendt-Nielsen L, Bjerring P, Nielsen J. Acta Derm Venereol 1990;70:314-318

43 Study Desensor 001. Wahlgren CF, Quiding H. J Am Acad Dermatol 2000;42:584-8.

44 https://www.1nep.ru/estetic/articles/13952/

45 Guide to dermatocosmetology, edited by E.R. Arabia and E.V. Sokolovsky. St. Petersburg: Foliant Publishing House LLC, 2008 - 632 pp.

46 https://www.1nep.ru/estetic/articles/132197/

47 https://medside.ru/dikain

48 https://medi.ru/instrukciya/novokain_9473/

49 https://medside.ru/anestezin

50 https://grls.rosminzdrav.ru/Default.aspx

51 Radman et al.2002, Yamashita., 2003

52 https://www.krasotaimedicina.ru/diseases/hematologic/methemoglobinemia

53 Evers H, Scott B, Dahlquist AC. Dermal analgesia after epicutaneous application of 5% cream, 5% prilocaine cream, 5% lidocaine cream and placebo cream, to volunteers. Study 89EM03 (n= 21, cross-over). CSR 802-10AC088-2,1989.

54 MASMI. A study of users of skin anesthetics. June 2018

55 O.M. Burylina, A.V. Karpova. Cosmetology. Clinical guidelines. GEOTAR-Media. Moscow, 2018

56 Postoperative pain: the role of peripheral and central sensitization mechanisms. https://rsra.rusanesth.com/publ/posleoperatcionnaya_bol.html

57 Paul M. Friedman, MD, Jushua P. Fogelman, MD and others. Comparative Study of the Efficacy of Four Topical Anesthetics. Dermatolog Surg 1999; 25:950-954

58 https://www.1nep.ru/articles/rynok-kosmeticheskikh-anestetikov-dlya-kozhi/

59 https://www.rlsnet.ru/mnn_index_id_879.htm

60 https://yandex.ru/health/pills/product/ultrakain-ds-2195

61 https://grls.rosminzdrav.ru/Default.aspx on 02/15/2021

62 Ziganshin O.R. Comparison of the effectiveness and safety of topical local anesthetics for superficial surgical interventions in dermatology. Clinical dermatology and venereology. 2018;17(6):53-60. https://doi.org/10.17116/klinderma 20181706153

63 Comparison of Topical Anesthetics for Radiofrequency Ablation of Achrocordons: Eutectic Mixture of Lignocaine/Prilocaine versus Lidocaine/Tetracaine Pratik Gahalaut,1 Nitin Mishra,1 Sandhya Chauhan,2 and Madhur Kant Rastogi11Department of Dermatology, Venereology and Leprosy, Shri Ram Murti Smarak Institute of Medical Sciences, Nainital Road, Bareilly 243001, India2Department of Pediatrics, Shri Ram Murti Smarak Institute of Medical Sciences, Nainital Road, Bareilly 243001, India

64 https://www.gazeta.ru/science/2012/11/01_kz_4837701.shtml

65 https://www.kp.md/daily/23716.3/53610/

66 https://doktorbel.livejournal.com/29873.html

67 https://politeka.net/zdorovye/870023-uchenye-vyjasnili-kak-muzhchiny-i-zhenshhiny-zapominajut-bol-kto-vynoslivee/

68 https://spacefacts.ru/news/people-and-medicine/psychology/792-udovolstvie-ili-bol.html

69 https://tattooinfo.ru/raznoe/foto-prokolotoj-guby-vidy-kak-delat-uxod-za-mestom-prokola.html

70 https://tatuazhpro.ru/pirsing/indastrial.html

71 https://sprs-therapy.ru/faq/V-kakih-sluchayah-nuzhno-primenyat-SPRS-terapiyu_i-v-kakih-nelzya

72 https://sprs-therapy.ru/faq/Kakim-obrazom-provoditsya-SPRS-terapiya

73 https://cosmetology-info.ru/6425/Metody-udaleniya-vtorogo-podborodka/

74 https://beauty.net.ru/public/inektsionnaya_konturnaya_plastika_nososleznoy_borozdy/

75 https://www.1nep.ru/articles/131016/

76 Morrison A.V., Bocharova Yu.M., Morrison V.V. Botulism toxin - a therapeutic effect in cosmetology (review). Saratov Scientific and Medical Journal 2016; 12(3):521–524.

77 A.V. Gara, V.G. Zolotareva, Features of botulinum therapy for aesthetic indications for patients over 45 years old, Injection methods in cosmetology No. 4-2011 – 54-60 s

78 Methodological manual on mesotherapy for students of postgraduate and additional professional education. / Shamov B.A., Dyadkin V.Yu., Zhelonkina T.I./ – Kazan: KSMU, 2011. – 60 p.

79 https://www.1nep.ru/estetic/articles/119953/

80 Evers H, Scott B, Dahlquist AC. Dermal analgesia after epicutaneous application of EMLA 5% cream, 5% prilocaine cream, 5% lidocaine cream and placebo cream, to volunteers. Study 89EM03 (n= 21, cross-over). CSR 802-10AC088-2,1989.

81 https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=019941

82 Superficial, medium or deep peeling: what to choose - https://medbooking.com/blog/post/

83 Features of medium peels – https://www.1nep.ru/estetic/articles/190169/

84 Facial peeling – https://cosmetology-info.ru/668/Piling-litsa/

85 Plastic surgery of cheekbones with fillers – https://cheap-fillers.ru/articles/plastika-skul-fillerami

86 Ozone therapy (O3) for the face - a revolutionary beauty technology - https://plastichno.com/cosmetology/ozonoterapiya-dlya-litsa#i-7

87 Effective face lift with liquid mesothreads: what is it and what are the popular brands? – https://beautyexpert.pro/kosmetologiya/inektsionnaya/tredlifting/vidy-nitej/zhidkie-mezoniti.html

88 Mesotherapy of the periorbital area using peptide cocktails – https://www.manuolog.ru/info/about/articles/stati-po-kosmetologii/mezoterapiya-periorbitalnoy-oblasti-s-primeneniem-peptidnykh-kokteyley/

89 Enzyme hair removal: getting rid of excess vegetation – https://plastikaplus.ru/kosmetologiya/epilyaciya/enzimnaya.html

90 Liquid mesothreads and traditional threadlifting: advantages and disadvantages – https://aesthetic-futures.com.ua/zhidkie-mezoniti-i-tradicionnyj-tredlifting-preimushhestva-i-nedostatki

91 Cannula in cosmetology and medicine – https://ladysdream.ru/kanyulya.html

92 7 myths about anesthesia: what are we afraid of? – https://www.psychologies.ru/articles/7-mifov-o-narkoze-chego-myi-boimsya/

93 Medium peeling - an uncompromising method of rejuvenation - https://plastichno.com/cosmetology/sredinnyj-piling#i-3

94 Khunger N. Standard guidelines of care for chemical peels. Indian J Dermatol Venereol Leprol 2008;74(Suppl):S5-S12 – https://pro.bhub.com.ua/cosmetology/himiceskie-pilingi-standartnye-rekomendacii-po-primeneniu#

95 Kim Lawless - 10 secrets of successful hair removal - https://www.cosmo.ru/beauty/body/10-sekretov-udachnoy-epilyacii/

96 All about Sugaring - https://www.gabbi-shugaring.ru/vse-o-shugaringe#rec61612476

97 Hirsutism – https://www.krasotaimedicina.ru/diseases/zabolevanija_endocrinology/hirsutism

98. Intralesional interferon therapy for recurrent warts, G. E. Bagramova, T.G. Sedova, A.N. Khlebnikova // Russian Journal of Skin and Venereal Diseases No. 1, 2013 – 23-26 p.

99. Korolkova T.N., Goma S.E. Study of the effect of mesotherapy with pineal gland peptides on skin moisture and elasticity, Russian Journal of Skin and Venereal Diseases. 2017; 20(5) – 305-310 p.

100. S.V. Klyuchareva, S.M. Nikonova, I.V. Ponomarev, Laser treatment of benign pigmented skin tumors, experimental and clinical dermatocosmetology No. 3, 2006 – 22-31 p.

101. Photorejuvenation in the complex correction of age-related skin changes, N.I. Tsisanova, Journal of Applied Aesthetics No. 1, 2007

102. https://plastichno.com/cosmetology/fotoomolozhenie

103. Current state of the problem of human papillomavirus infection / L. A. Yusupova, E. I. Yunusova, Z. Sh. Garayeva, G. I. Mavlyutova, K. A. Salakhutdinova // Attending physician No. 7/2019; Page numbers in the issue: 64-67 – https://www.lvrach.ru/2019/07/15437345

104. Human papillomavirus infection of the genitals in women, S.I. Rogovskaya, V.N. Prilepskaya, E.A. Mezhevitinova, M.N. Kostava // Bulletin of Dermatology and Venereology, N 6-1998, pp. 48-51. – https://nature.web.ru/db/msg.html?mid=1178539&uri=index.html

105. https://www.1nep.ru/estetic/articles/183501/

106. https://www.1nep.ru/articles/208888/

107. https://cosmetology-info.ru/6925/salon-procedures-Lipolitiki-dlya-litsa/

108. https://www.1nep.ru/articles/204894/

109. https://www.verywellhealth.com/stratum-corneum-anatomy-1069189

110. Turkin P.Yu., Rodionov S.V., Somov N.O., Mirgatia I.O. Venous trophic ulcers: current state of the issue // General Medicine. 2021. No. 1. URL: https://cyberleninka.ru/article/n/venoznye-troficheskie-yazvy-sovremennoe-sostoyanie-voprosa

111. Kruglova Larisa Sergeevna, Panina Anastasia Nikolaevna, Strelkovich Tatyana Igorevna Trophic ulcers of venous origin // Russian Journal of Skin and Venereal Diseases. 2014. No. 1. URL: https://cyberleninka.ru/article/n/troficheskie-yazvy-venoznogo-geneza

112. Yu.M. Stoiko, A.I. Kirienko, I.I. Zatevakhin, A.V. Pokrovsky, A.A. Karpenko et al., Russian clinical guidelines for the diagnosis and treatment of chronic venous diseases // Phlebology No. 3, 2021 – 143-240 pp. — https://webmed.irkutsk.ru/doc/pdf/ven2009.pdf

113. Dovnar R.I., Smotrin S.M. Trophic ulcers of the lower extremities: modern aspects of etiology and pathogenesis // Journal of GrSMU. 2009. No. 4 (28). URL: https://cyberleninka.ru/article/n/troficheskie-yazvy-nizhnih-konechnostey-sovremennye-aspekty-etiologii-i-pathogeneza

114. Burleva E.P., Babushkina Yu.V. Experience in outpatient treatment of trophic foot ulcers that complicated the course of diabetes mellitus // Hospital-replacing technologies: Outpatient surgery. 2021. No. 3-4. URL: https://cyberleninka.ru/article/n/opyt-ambulatornogo-lecheniya-troficheskih-yazv-stop-oslozhnivshih-techenie-saharnogo-diabeta

115. Kutsenko I.V., Andrashko Yu.V. Conservative treatment of trophic ulcers of the lower extremities in chronic venous insufficiency // Methodological recommendations. 2007. https://medinfo.center/wp-content/uploads/2019/12/metodichka-tya.pdf

116. Trophic ulcers of the lower extremities in outpatient clinic practice//Methodological recommendations for fourth-year students of the Faculty of Medicine. 2020 https://rsmu.ru/fileadmin/templates/DOC/Faculties/LF/fsurg2/algoritm_dignost/UP/3._UP_Troficheskie_rasstroi__stva_kozhi_nizhnikh_konechnostei__.pdf

117. Russian clinical guidelines for the diagnosis and treatment of chronic venous diseases. Phlebology, issue No. 2. 2013 https://www.mrckb.ru/files/flebologii.pdf

118. I. L. Mikitin, G. Z. Karapetyan, L. V. Kochetova, S. V. Yakimov, R. A. Pakhomova Modern view on the treatment of trophic ulcers // Creative surgery and oncology. 2013. No. 4. URL: https://cyberleninka.ru/article/n/sovremennyy-vzglyad-na-lechenie-troficheskih-yazv

119. Aralova M.V. Personalized technology for regional treatment of patients with trophic ulcers of the lower extremities. dis. for the academic degree of Doctor of Medical Sciences Voronezh, 2019

120. Lok et al. J Amer Acad Derm 1999;40:208-13. (Study EM9405)

121. Hansson C et al. Acta Derm Venereol (Stockh) 1993;73:231-233.

122. Order of the Ministry of Health of Russia dated October 13, 2017 No. 804n “On approval of the range of medical services.

123. Order of the Ministry of Health dated October 8, 2018 No. 707n “On approval of qualification requirements for medical and pharmaceutical workers with higher education in the field of training “Health and Medical Sciences”

124. 124. Starostina L.S. Helping control pain in children: advice from a pediatrician. Medical advice. 2021;(1):263–268. doi: 10.21518/2079-701X-2021-1-263-268

Akriol Pro, 2.5%+2.5%, cream for local and external use, 30 g, 1 pc.

Locally,

on the skin or mucous membrane.

Superficial anesthesia of intact skin

Table 1

Superficial anesthesia of trophic ulcers of the lower extremities

For surgical treatment (mechanical cleaning) of trophic ulcers of the lower extremities: a single dose of about 1–2 g/10 cm2; Apply the cream in a thick layer to the ulcer surface, no more than 10 g of cream per procedure. Apply an occlusive dressing. Application time: minimum 30 min.

An opened tube of cream is intended for single use; the tube with any remaining cream should be discarded after use on one patient.

In the case of treating ulcers, into the tissues of which penetration of the drug is difficult, the duration of application can be increased to 60 minutes. Mechanical cleaning must begin no later than 10 minutes after removing the cream.

When manipulating ulcers of the lower extremities, the drug was used up to 15 times over 1–2 months without reducing the effectiveness and increasing the incidence of local reactions.

Superficial anesthesia of the genital organs

Skin of the genital organs.

Anesthesia before injections of local anesthetics: men - 1 g/10 cm2; women - 1–2 g/10 cm2. Apply the cream in a thick layer to the skin. Application time is 15 minutes (for men) or 60 minutes (for women).

Superficial anesthesia of the mucous membrane of the genital organs.

When removing condylomas and for pain relief before injections of local anesthetics: approximately 5–10 g of cream, depending on the area of ​​the treated surface. The cream should be applied to the entire surface of the mucous membrane, including the folds of the mucous membrane. No occlusive dressing is required. Application time: 5–10 min. Carry out the procedure immediately after removing the cream.

Children

Anesthesia during needle insertion (including vaccination), when curettage of molluscum contagiosum and other minor superficial surgical procedures. Apply the cream in a thick layer to the skin and cover with an occlusive dressing. The dose should correspond to the surface being treated and should not exceed 1 g of cream per 10 cm2.

table 2

A strip of Acriol Pro 3.5 cm long approximately corresponds to a dose of 1 g.

Increasing the application time reduces anesthesia. In children with atopic dermatitis, the application time should be reduced to 30 minutes. Apply the cream in a thick layer to the skin and cover with an occlusive dressing.

Recommendations for applying the drug

Pierce the protective membrane of the aluminum tube using the screw cap, squeeze out a sufficient amount of cream from the tube and apply to the site of the intended procedure.

When anesthetizing the skin, it is possible to use occlusive stickers. When anesthetizing trophic ulcers of the lower extremities, an occlusive PVC dressing should be used. It is necessary to cover the applied cream with a bandage so that the layer of cream underneath is thick and does not squeeze out from under the bandage. Gently smooth the edges of the bandage to avoid cream leakage.

After the recommended time has passed, remove the bandage and any remaining cream from the surface.