Experience of using Mildronate in cerebrovascular diseases

Description of the drug

The main active ingredient is meldonium. Produced in Latvia, Poland, Lithuania and Slovakia.

Presented in pharmacy chains in two forms:

1. A transparent solution for injection, 1 ml of which contains 100 mg of the main substance.
2. Gelatin capsules with 250 or 500 mg of meldonium dihydrate. Contents: white powder with a slight odor and sweetish taste.

The solution is sold in ampoules of 5 ml, a cardboard box contains 10 ampoules and instructions for use.

Meldonium is a synthetic drug with an effect similar to the precursor substance hydroxytrimethylaminobutyric acid, related to B vitamins.

The substance is able to improve metabolic processes and provide cells with energy.

Meldonium:

• Increases performance.
• Reduces the manifestations of mental, physical and mental stress.
• Increases the strength of heart contractions.
• Reduces the frequency of angina attacks.
• Increases the body's endurance during physical activity.

The medicine should be stored in a dry place at temperatures up to 25°C for no more than 4 years.

MILDRONATE (solution)

Iem.
The drug Mildronate contains the main component meldonium. To put it in accessible Russian language, this is a remedy that normalizes the metabolic process in the body, in this case it is cellular energy metabolism. After ischemia and hypoxia. Essential for the heart and other organs after severe changes.

Still couldn’t say it in Russian. But speaking exaggeratedly, the drug supports energy and energy metabolism in cells after ischemia and hypoxia.

This is what a typical box of the drug Mildronate from Grindeks looks like. Previously, the exact same drug was produced by the Pharmstandard company, that is, the boxes were indistinguishable except for the trademark. Previously, the companies collaborated and Pharmstandard brought the Latvian medical product to the Russian market, but this year they went their separate ways and now Mildronate can be found in pharmacies only under the Grindeks brand. If you see this drug Pharmstandard, then look at the production date, it is either old imports or a fake. Pay attention to this.

There is also one difference between Grindeks and Pharmstandard; now there is an inscription on the box that it can be administered intramuscularly, this was not the case before. Although I personally didn’t find any more changes in the composition or anything else. The solution for administration of Mildronate contains Meldonium 100 mg. and water solution for injection 1 ml.

The drug is produced in Lithuania; by the way, it was invented there in the 70s.

Shelf life: 4 years.

The drug is produced by Santonika LLC, and owns the patent for it and produces it under its own brand. There are a total of 10 5 mg ampoules in the box. There are quite clear and understandable instructions inside.

Indications for use are quite extensive. In the complex treatment of the heart, coronary disease (infarction, myocardial infarction, senocardia). Also for chronic heart failure and complex therapy for disorders of the blood supply to the brain (stroke), etc. The drug has contraindications for use: intracranial pressure and tumors, age under 18 years, pregnancy and lactation. As well as individual intolerance to the drug. The drug is sold by prescription only. It is also used in the treatment of chronic alcoholism.

We, in turn, buy this drug for my father, as prescribed by a doctor, as part of complex therapy after a stroke, which shows good results every time.

For the course we need 20 ampoules, 2 packages.

Of course, if a doctor prescribed this medicine for you, then I would take a course, since the heart and blood circulation are not to be joked about.

And by the way, this drug is considered prohibited for athletes who have a career, since Meldonium is included in the list of doping agents.

But of course it’s better to be healthy and not get sick!

Why take Mildronate?

The drug is used only in the treatment of adults. Regardless of the dosage form, the indications for prescribing Mildronate are:

1. Heart diseases caused by impaired coronary circulation (in complex therapy).
2. Chronic heart failure and cardialgia.
3. Reduced performance.
4. Pathologies of peripheral arteries.
5. The recovery period after surgery to restore the body.
6. Encephalopathy.
7. Stroke.
8. Bronchial asthma and chronic obstructive pulmonary disease.
9. II and III stages of alcoholism.
10. Violations of the integrity of the vessels supplying blood to the tissues of the eye.

The use of Mildronate slows down the formation of necrotic areas and shortens the rehabilitation period after acute damage to cardiac muscle tissue.

During active training, meldonium restores the balance of oxygen in cells, prevents the accumulation of toxins, and helps restore energy reserves.

The drug is successfully used in sports in healthy people because:

• Increases adaptability to physical activity.
• Improves muscle nutrition, including the heart, and accelerates their recovery.
• Reduces fatigue.
• Increases the effect of sports.

Mildronate is not suitable for gaining muscle mass, but is used to prevent overwork.

Contraindications and side effects

It is prohibited to use Mildronate for:

• Individual intolerance to meldonium or any of the auxiliary components.
• Increased intracranial pressure, caused, among other things, by a tumor and impaired venous outflow.

Undesirable effects from taking the drug may appear in the form of:

• Allergic manifestations - itching, rashes, redness or swelling.
• Rapid heartbeat.
• Reactions from the digestive system - nausea, vomiting, heartburn, belching.
• Excessive stimulation of the nervous system.

In general, Mildronate is a low-toxic drug that does not cause life-threatening conditions. However, Mildronate is not used in pediatrics. Also, the drug is not prescribed during pregnancy and breastfeeding.

Instructions for use of Mildronate

The solution is administered undiluted intravenously according to indications; the capsules are used orally as a whole without crushing.

Mildronate injections

Prescribed for progressive angina, vascular pathologies of the fundus, cerebral circulatory disorders, myocardial infarction. In case of a heart attack, it is administered once a day in a volume of 500-1000 mg. Further treatment is carried out with capsules.

For vascular pathologies of the fundus of the eye, the solution is administered behind the eyeball or under its outer shell, 0.5 ml for 10 days.

To persons with acute circulatory disorders in the brain, Mildronate is administered intravenously once a day at a dose of 500 mg. The duration of the course of treatment is 10 days. Then the patient is transferred to capsules at a dosage of 500-1000 mg per day in one or two doses.

Mildronate capsules

Prescribed to patients suffering from diseases of the cardiovascular system as additional therapy at a dose of 500-1000 mg. It can be taken once or divided into two doses. Duration of therapy is 4-6 weeks. You can repeat courses as prescribed by your doctor 2-3 times a year.

For cardialgia, take one tablet of Mildronate 500 mg once a day.

For pathologies of peripheral arteries, the medicine is taken twice a day, 500 mg.

Athletes and people experiencing increased intellectual and physical stress can take 1000 mg in two doses for 10-14 days. After 14-21 days the course can be repeated.

For persons suffering from chronic alcoholism, Mildronate is prescribed 500 mg four times a day for 7-10 days.

The maximum dose of the drug is 2000 mg. It is recommended to take before lunch due to its stimulating effect.

We tell you what chronic fatigue syndrome is and how to get rid of it

Constant weakness and drowsiness, problems with attentiveness, bad mood—is this a familiar situation? Of course, such a broken state can occur after a hard week of work. But if the weekend comes and you still can’t recover, this problem needs to be solved - it won’t go away on its own.

Together with the manufacturer Grindeks and the product Mildronate ® 250, we will understand what asthenia is, or, as it is also called, chronic fatigue, and whether it is possible to get rid of it.

What is asthenia?

Asthenia is not a disease in the usual sense, but a condition that says that something is wrong with the body. It is accompanied by constant fatigue, loss of strength, loss of attentiveness and concentration. A person with asthenia becomes irritable and lethargic, and stops getting enough sleep.

Sometimes the manifestations of asthenia are similar to the onset of the flu - the temperature may rise, photophobia and sensitivity to sharp sounds may occur, and appetite may decrease. But unlike a viral infection, symptoms last longer, and bed rest does not help recovery.

With asthenia, a person cannot recover from exercise, loses concentration and is often irritated.

Asthenia or fatigue: how to distinguish

Often the body is able to recover from stress and fatigue within a few days. For example, if a person has had a hard week at work, it is enough to get enough sleep over the weekend to be fresh and energetic on Monday.

But if stress and tension become faithful companions, then in two days the body simply does not have time to rest. Fatigue accumulates and as a result, even a week may not be enough to recover.

Asthenia, unlike overwork, is not a consequence of physical or mental stress and does not disappear after rest.

With asthenia, it is not enough to just sleep. As a result, the person becomes irritable and absent-minded

Causes of asthenia

• Irregular work schedule. For example, a person should work from 9 to 18, but in fact he arrives at work at 8 and leaves at 21, and sometimes even works on weekends.
• High load. Those at risk are those who combine a lot of things: work and study, raising children, gym, entertainment and self-development. In such a busy schedule, a person simply has no time to rest.
• Constant stress at work. For example, if a person goes to work as if he were going to war, and there are rush jobs or an angry boss waiting for him. All this affects the psychological state and leads to asthenia.
• No vacation. A person may feel that without him everything at work will be lost, so it is better to go on vacation only for a week and once a year. But the body will not be able to recover from a year’s stress in such a short time.
• Malnutrition. We need to find energy for life. But if, instead of a full lunch, we snack on chocolate and coffee, the body simply has nowhere to get strength.

Of course, if you live in a mode of constant work and stress for a week or even a month, you may not feel that anything is wrong with your body. But if fatigue accumulates and a person does not have the resources to recover, then burnout begins and asthenia appears.

Sometimes it occurs along with some disease. For example, a person has been poisoned by something, the body has devoted all its efforts to recovery, but there are not enough resources for recovery.

Unfortunately, people rarely turn to doctors at the first signs of asthenia. It seems that this is all banal fatigue or just laziness. But asthenia can and should be treated

I have asthenia. What to do about it?

Of course, you should not self-medicate. Only a specialist can find out what is happening to you. To determine whether you have asthenia, you need to go to the doctor and get tested.

To recover, you need to remove all the causes of asthenia - start eating right, resting more, doing things not related to work and family.

And in order to support the body, you can start taking vitamins or special medications, such as Mildronate ®250, which supports:

• Cardiovascular system. With stress and fatigue, the heart begins to work to the limit and a lack of oxygen occurs. Thanks to meldonium in the composition, Mildronate ®250 helps deliver oxygen to cells, reduces the risk of damage to the cell membranes of the heart and has a tonic effect
• Nervous system. Mildronate ®250 stimulates the central nervous system and increases motor activity and physical endurance.

Mildronate ®250 is suitable for those who:

• Leads an active lifestyle and wants to recover quickly after training.
• Works in an office and experiences stress or constant fatigue.
• People who want to find time for everything - from work to family and entertainment.

During physical and mental overload, Mildronate® quickly restores energy reserves and increases the body's resistance to stress.