Pharmacodynamics and pharmacokinetics
The effect of this combination drug is determined by the components that are present in its composition.
Paracetamol is able to exhibit an analgesic and antipyretic effect by influencing central thermoregulation in the hypothalamus. This also lowers body temperature and eliminates headaches and other painful sensations.
Ascorbic acid is one of the regulators of redox processes, tissue regeneration, GCS production, blood , carbohydrate metabolism, procollagen and collagen , and helps normalize capillary permeability. The use of this vitamin increases the body's resistance by stimulating the immune system.
The substance pheniramine is a H1-histamine receptor blocker. With its help, the manifestations of rhinorrhea, nasal congestion, lacrimation, sneezing, redness and itching of the eyes are reduced.
Inside the body, the drug undergoes rapid and complete absorption. Its maximum concentration in plasma is detected 30-60 minutes after application. Good distribution in tissues and physiological fluids, but also penetration through the BBB was noted. The connection with plasma proteins is completely insignificant. Metabolism occurs within the liver, resulting in the formation of inactive metabolites . The components of Fervex are excreted through the kidneys.
Pharmacokinetics
Fervex for children
Paracetamol.
Absorption of paracetamol is complete and rapid. Peak plasma concentrations are reached 30–60 minutes after administration. The distribution of paracetamol in tissues occurs quickly. Comparable drug concentrations are achieved in blood, saliva and plasma. Plasma protein binding is low, 10–25%. Penetrates through the BBB.
Metabolism occurs in the liver, 80% enters into conjugation reactions with glucuronic acid and sulfates to form inactive metabolites; 17% undergoes hydroxylation to form 8 active metabolites, which conjugate with glutathione to form inactive metabolites. With a lack of glutathione, these metabolites can block the enzyme systems of hepatocytes and cause their necrosis. The isoenzyme CYP2E1.T1/2 is also involved in the metabolism of the drug - 1–4 hours. It is excreted by the kidneys in the form of metabolites, mainly conjugated. Less than 5% is excreted unchanged.
Pheniramine maleate.
Well absorbed from the digestive tract. T1/2 from blood plasma is 1–1.5 hours. It is excreted from the body mainly through the kidneys.
Ascorbic acid.
Well absorbed from the digestive tract. Tmax after oral administration is 4 hours. Metabolized primarily in the liver. It is excreted by the kidneys, through the intestines, with sweat - unchanged and in the form of metabolites.
Contraindications
Contraindications to the use of Fervex:
- sensitivity to the drug;
- erosions and ulcers of the gastrointestinal tract;
- renal failure;
- alcoholism;
- portal hypertension;
- deficiency of the enzyme glucose-6-phosphate dehydrogenase;
- age up to 15 years;
- lactation, pregnancy.
Fervex for children is contraindicated for:
- sensitivity to it;
- severe liver and kidney disorders;
- lactation , pregnancy ;
- deficiency of the enzyme glucose-6-phosphate dehydrogenase;
- blood diseases;
- children under 6 years of age.
Use with extreme caution is allowed for benign hyperbilirubinemia and diabetes mellitus .
Side effects
When treated with Fervex, side effects develop quite rarely, especially if you follow the recommended dosages. However, the manifestation of: nausea, abdominal pain, allergic reactions - skin rash, itching, urticaria, Quincke's edema is possible.
Side effects
Fervex
Fervex for children
The drugs are well tolerated in recommended doses.
Nausea, pain in the epigastric region, allergic reactions (skin rash, itching, urticaria, Quincke's edema).
Rarely - hematopoietic disorders (anemia, thrombocytopenia, methemoglobinemia), dry mouth, accommodation paresis, urinary retention, drowsiness. With long-term use (in doses significantly higher than recommended), the likelihood of liver and kidney dysfunction increases; monitoring of the peripheral blood picture is necessary. All side effects of the drug should be reported to your doctor. If adverse reactions occur, you should stop taking the drug and consult a doctor.
Instructions for use of Fervex (Method and dosage)
This drug is intended for oral administration. First, the contents of the sachet are completely dissolved in a glass of water and immediately drunk. The optimal time to take it is between meals.
It is recommended to take 1 sachet no more than 2-3 times a day. In this case, an interval of 4 hours must be observed. For elderly patients and those suffering from liver or kidney disorders, this interval is 8 hours.
The course of treatment is no more than 5 days.
Instructions for use of Fervex for children also recommend taking it orally, after thoroughly dissolving the powder in 200 ml of water.
In this case, children's Fervex is prescribed taking into account the age of the small patient. Therefore, Fervex for children 6-10 years old is recommended in a daily dosage of 1 sachet for 2 doses. At the age of 10-12 years you can take one sachet 3 times a day, and at 12-15 years old - one sachet up to 4 times a day.
The instructions for children advise maintaining an interval of 4 hours between doses. The duration of therapy is no more than 3 days.
special instructions
Fervex
If you are taking metoclopramide, domperidone or cholestyramine, you should also consult your doctor.
It is possible to distort laboratory test results when quantifying the concentration of uric acid and glucose in plasma. To avoid toxic liver damage, paracetamol should not be combined with alcoholic beverages, or taken by persons prone to chronic alcohol consumption. The risk of developing liver damage increases in patients with alcoholic hepatosis.
If the drug is taken by patients suffering from diabetes or on a low-sugar diet, it should be taken into account that each sachet contains 11.5 g of sugar, which corresponds to 0.9 XE.
Additionally for Fervex lemon without sugar: the drug does not contain sugar and can be used by patients suffering from diabetes.
Fervex for children
The drug should not be used simultaneously with other medications containing paracetamol.
When using the drug for more than a week, monitoring the functional state of the liver and peripheral blood patterns is necessary.
If the drug is taken by children with diabetes or on a low-sugar diet, it should be taken into account that each sachet contains 2.4 g of sucrose.
Paracetamol distorts the results of laboratory tests of glucose and uric acid in blood plasma.
If there is no therapeutic effect (fever persists for more than 3 days and pain persists for more than 5 days), a doctor’s consultation is required.
Overdose
When taking Fervex for a long time in an increased dosage, symptoms such as pale skin, decreased appetite , hepatonecrosis, nausea, and vomiting may appear. , liver failure may occur .
Treatment includes mandatory measures in such cases: gastric lavage, use of SH-group donors or precursors for the production of glutathione-methionine 8-9 hours after the overdose. If the overdose period is 12 hours, then N-acetylcysteine is administered. At the same time, other accompanying measures are carried out, which depend on the symptoms that appear.
Interaction
Combination with antidepressants, antiparkinsonian and antipsychotic drugs may increase the risk of side effects.
Simultaneous use with inducers of microsomal oxidation in the liver, for example, with Phenytoin, barbiturates, Rifampicin, Phenylbutazone and tricyclic antidepressants , can increase the production of hydroxylated active metabolites, which may result in the development of severe intoxications .
Fervex's analogues
Level 4 ATC code matches:
Phenacetin
Combiflu
Chlorphenamine
Coldflu
Calpol
Panadol Extra
Panadol for children
Panadol
Solpadeine
Efferalgan
Milistan
Coldrex Maxgripp
Coldrex Hotrem
Coldrex
AntiGrippin
Unispaz
Pentalgin Plus
Rapidol
Maxicold
Perfalgan
The main analogues of Fervex: Bioparox, Sinupret, Teraflu, Coldrex.
Which is better – Fervex or Theraflu?
Each of these drugs has a similar composition and indications for use. However, Theraflu effect is not reduced.
In this case, the antipyretic and analgesic effect manifests itself almost equally.
What is Fervex?
The drug Fervex is a dry powder for preparing a solution, which includes:
- Paracetamol is an antipyretic, analgesic and anti-inflammatory agent.
- Ascorbic acid or vitamin C is a supplement that strengthens the walls of blood vessels and improves immunity.
- Pheniramine is an antihistamine (antiallergic) component.
The main substance in the drug is paracetamol, the action of which does not pose a danger to the developing fetus from a certain stage of development.
It can be argued that Fervex is a mixture of regular paracetamol and ascorbic acid in powder, packaged in bright packaging.
Pheniramine has antiallergic properties, eliminates nasal congestion and itching, but it does not cure, but blocks severe symptoms. Doctors do not have reliable information about the safety of Fervex during pregnancy, so you should not use it often.
Reviews about Fervex
There are a lot of reviews about Fervex on medical forums. According to users, if you take this drug at the first sign of a cold, the development of the disease can be quickly stopped. At the same time, great importance is given to bed rest, drinking plenty of fluids and proper rest - all this, together with the drug, provides good support to the body, increasing its resistance to viral infection.
Users often discuss Fervex for children, which can be taken by young patients from 6 years of age. At this age, it is difficult for children to give pills, but they take drugs in the form of suspensions, sweet solutions and syrups more willingly. The effectiveness of this drug is also maximal when it is started when the first symptoms of the disease appear.
Among the positive opinions, there are reviews of Fervex that report the development of side effects. drowsiness is especially often mentioned , which, however, is also typical for viral infections.
You can also find reports that treatment with this drug turned out to be completely useless. After therapy for several days, the cold symptoms not only did not decrease, but, on the contrary, became more complicated. In addition, inflammation in the throat, muscle aches and headaches increased.
Unfortunately, many people consider colds to be commonplace and do not make special efforts to treat them. They often try to suppress the symptoms that appear, but this approach often leads to complications, the treatment of which requires radical measures, including taking antibiotics .
Therefore, if it was not possible to reduce the manifestation of a cold within 2-3 days, you need to consult a doctor. The specialist will prescribe appropriate medications and additional examination, which will help to achieve a quick recovery.
Fervex
Fervex por d/prig solution vn lemon with sugar 500 mg+25 mg+200 mg x8 Release form, packaging and composition of Fervex®
Powder for preparing a solution for oral administration (lemon with sugar) is light beige in color, inclusions of brown are allowed, the prepared solution is light yellow with a grayish tint, opalescent.
1 pack
paracetamol 500 mg
pheniramine maleate 25 mg
ascorbic acid 200 mg
Excipients: sucrose - 11.555 g, citric acid - 0.2 g, acacia gum - 0.1 g, sodium saccharinate dihydrate - 0.02 g, lemon-rum flavoring * - 0.5 g.
Powder for preparing a solution for oral administration (raspberry with sugar) from light pink to light beige, dark pink inclusions are allowed, the prepared solution is pink, slightly opalescent.
1 pack
paracetamol 500 mg
pheniramine maleate 25 mg
ascorbic acid 200 mg
Excipients: sucrose - 11.555 g, citric acid - 0.2 g, acacia gum - 0.1 g, sodium saccharinate dihydrate - 0.02 g, raspberry flavor** - 0.15 g.
* composition of lemon-rum flavor: maltodextrin, acacia gum, α-pinene, β-pinene, limonene, γ-terpinene, linalool, neral, α-terpineol, geranial, dextrose, silicon dioxide, butylated hydroxyanisole. ** composition of raspberry flavor: ethyl acetate, isoamyl acetate, acetic acid, benzyl alcohol, triacetin, vanillin, p-hydroxy-benzylacetone, maltodextrin, E1450 modified corn starch, E129 charming red dye, E133 brilliant blue dye, E110 sunset yellow dye, permastabil 505528 RI, raspberry 054428 A, sodium chloride and/or sodium sulfate.
Clinical-pharmacological group: Drug for symptomatic treatment of acute respiratory diseases Pharmaco-therapeutic group: Drug for eliminating the symptoms of acute respiratory infections and “colds” (analgesic non-narcotic drug + vitamin + H1-histamine receptor blocker)
pharmachologic effect
Fervex® is a combination drug that contains paracetamol, pheniramine and ascorbic acid.
Paracetamol is a non-narcotic analgesic that blocks cyclooxygenase, mainly in the central nervous system, affecting the centers of pain and thermoregulation, and has an analgesic and antipyretic effect.
Pheniramine is a histamine H1 receptor blocker, reduces rhinorrhea and lacrimation, eliminates spastic phenomena, swelling and hyperemia of the mucous membrane of the nasal cavity, nasopharynx and paranasal sinuses.
Ascorbic acid is a cofactor in some hydroxylation and amidation reactions - it transfers electrons to enzymes, providing them with a reducing equivalent. Participates in the reactions of hydroxylation of proline and lysine residues of procollagen with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), oxidation of lysine side chains in proteins with the formation of hydroxytrimethyllysine (in the process of carnitine synthesis), oxidation of folic acid to folinic acid, metabolism of drugs in liver microsomes and hydroxylation dopamine to form norepinephrine. Increases the activity of amidating enzymes involved in the synthesis of oxytocin, adrenocorticotropic hormone and cholecystokinin. Participates in steroidogenesis in the adrenal glands.
Pharmacokinetics
Paracetamol
Absorption is high. The time required to achieve the maximum concentration (TCmax) is 30-60 minutes, the maximum concentration (Cmax) is 5-20 μg/ml. Plasma protein binding - 15%. Penetrates the blood-brain barrier (BBB).
Metabolized in the liver in three main ways: conjugation with glucuronides, conjugation with sulfates, oxidation by microsomal liver enzymes. In the latter case, toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine and mercapturic acid. The main isoenzymes of cytochrome P450 for this metabolic pathway are the isoenzyme CYP2E1 (mainly), CYP1A2 and CYP3A4 (minor role). With glutathione deficiency, these metabolites can cause damage and necrosis of hepatocytes.
Additional metabolic pathways include hydroxylation to 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates.
Conjugated metabolites of paracetamol (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity. T1/2 - 1-4 hours. Excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged.
In elderly patients, drug clearance decreases and T1/2 increases.
Pheniramine
Well absorbed in the digestive tract. T1/2 from blood plasma is from 1 to 1.5 hours. It is excreted from the body mainly through the kidneys.
Ascorbic acid
Well absorbed in the digestive tract. The time to create the maximum therapeutic concentration (TCmax) after oral administration is 4 hours. Metabolized primarily in the liver. It is excreted by the kidneys, through the intestines, with sweat, unchanged and in the form of metabolites.
Plasma protein binding - 25%. Easily penetrates into leukocytes, platelets, and then into all tissues, the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye, penetrates the placental barrier. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations.
Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic acid and ascorbate-2-sulfate.
It is excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and in the form of metabolites. Excreted during hemodialysis.
Indications for Fervex®
As a symptomatic therapy for acute respiratory viral infections to relieve the following symptoms:
rhinorrhea, nasal congestion, headache, fever, lacrimation, sneezing. ICD-10 codes
Dosage regimen
Orally, 1 sachet 2-3 times/day. Before use, the contents of the sachet must be dissolved in a glass (200 ml) of warm water. The maximum duration of treatment is 5 days.
The maximum daily dose of paracetamol for a body weight of more than 50 kg should not exceed 4 g (or 8 sachets of Fervex®), in children or patients weighing 40-50 kg, the maximum daily dose of paracetamol should not exceed 3 g, for a body weight of less than 40 kg - no more than 2 g.
The interval between doses of the drug should be at least 4 hours.
In patients with impaired renal function (creatinine clearance (CC) <.10 ml/min), the interval between doses of the drug should be at least 8 hours.
In patients with chronic or decompensated liver diseases, in patients with liver failure, chronic alcoholism, in malnourished patients and in cases of dehydration, the daily dose of paracetamol should not exceed 3 g.
The drug should not be taken for more than 3 days as an antipyretic and for more than 5 days as an analgesic.
If there is no relief of symptoms within 5 days after starting to take the drug, the body temperature remains elevated, or after an initial decrease it suddenly rises again, the patient should consult a doctor.
Side effect
The drug is well tolerated in recommended doses. When using the drug, the following side effects were observed (frequency not established).
From the hematopoietic system: anemia, leukopenia, agranulocytosis, thrombocytopenia.
From the immune system: allergic reactions (erythema, skin rash, itching, Quincke's edema, anaphylactic shock).
From the nervous system: drowsiness, confusion, hallucinations, impaired concentration (more often in elderly patients), agitation, nervousness, insomnia, coordination dysfunction, tremor.
On the part of the organ of vision: disturbance of accommodation.
From the cardiovascular system: palpitations, orthostatic hypotension, dizziness.
From the digestive system: dry mouth, nausea, vomiting, abdominal pain, constipation.
From the urinary system: difficulty urinating.
If adverse reactions occur, the patient should stop taking the drug and consult a doctor.
Contraindications for use
erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), liver failure, angle-closure glaucoma, urinary retention associated with prostate diseases and urinary disorders, portal hypertension, alcoholism, phenylketonuria, glucose-galactose malabsorption, sucrase/isomaltase deficiency, fructose intolerance, children age (up to 15 years), pregnancy (safety has not been studied), lactation (safety has not been studied), hypersensitivity to paracetamol, ascorbic acid, pheniramine or any other component of the drug.
With caution: renal failure, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), viral hepatitis, alcoholic hepatitis, old age, diabetes mellitus.
Use during pregnancy and breastfeeding
There have been no adequate and well-controlled studies of Fervex® in pregnant women, so the use of the drug in this group of patients is not recommended.
It is not known whether the active substances of the drug pass into breast milk. The drug should not be used during lactation.
Use for liver dysfunction
The drug should be used with caution in case of liver failure, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), viral hepatitis, alcoholic hepatitis.
Use for impaired renal function The drug should be used with caution in case of renal failure.
Use in children The use of the drug in children under 15 years of age is contraindicated.
Use in elderly patients The drug should be used with caution in elderly patients.
special instructions
Fervex® should not be used simultaneously with other drugs containing paracetamol.
To avoid toxic liver damage, paracetamol should not be combined with alcoholic beverages, or taken by persons prone to chronic alcohol consumption.
The risk of developing liver damage increases in patients with alcoholic hepatosis.
If the recommended doses are exceeded and with prolonged use, mental dependence on the drug may appear.
To avoid an overdose of paracetamol, you should ensure that the total daily dose of paracetamol contained in all medications taken by the patient does not exceed 4 g.
Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood and urine glucose, bilirubin, liver transaminase and LDH activity).
If the drug is taken by patients with diabetes or on a low-sugar diet, it should be taken into account that each sachet contains 11.555 g of sucrose, which corresponds to 0.9 XE.
Impact on the ability to drive vehicles and operate machinery
Considering the possibility of developing undesirable effects such as drowsiness and dizziness, it is recommended to refrain from driving a car or using machinery during treatment with the drug.
Overdose
Symptoms due to paracetamol
In case of overdose, intoxication is possible, especially in elderly patients, children, patients with liver diseases (caused by chronic alcoholism), in patients with malnutrition, as well as in patients taking inducers of microsomal liver enzymes, in which fulminant hepatitis, liver failure, cholestatic hepatitis, in the above cases - sometimes fatal. The overdose threshold may be lower in these categories of patients. The clinical picture of acute overdose develops within 24 hours after taking paracetamol.
Symptoms: gastrointestinal disorders (nausea, vomiting, loss of appetite, abdominal discomfort and (or) abdominal pain), pale skin. When administered simultaneously to adults of 7.5 g or more or to children of more than 140 mg/kg, cytolysis of hepatocytes occurs with complete irreversible liver necrosis, the development of liver failure, metabolic acidosis and encephalopathy, which can lead to coma and death. 12-48 hours after the administration of paracetamol, there is an increase in the activity of microsomal liver enzymes, lactate dehydrogenase, bilirubin concentration and a decrease in prothrombin concentration. Clinical symptoms of liver damage appear 2 days after an overdose of the drug and reach a maximum on days 4-6.
Treatment: immediate hospitalization. Determination of the quantitative content of paracetamol in blood plasma before starting treatment as early as possible after an overdose. Administration of SH-group donors and precursors of glutathione synthesis - methionine and acetylcystine - is most effective in the first 8 hours. The need for additional therapeutic measures (further administration of methionine, intravenous administration of acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as time elapsed after its introduction. Symptomatic treatment. Laboratory tests of the activity of microsomal liver enzymes should be carried out at the beginning of treatment and then every 24 hours. In most cases, the activity of microsomal liver enzymes normalizes within 1-2 weeks. In very severe cases, a liver transplant may be required.
Symptoms caused by the action of ascorbic acid
Symptoms: nausea, diarrhea, irritation of the gastrointestinal mucosa, flatulence, spastic abdominal pain, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia.
Treatment: Stop using the drug immediately and consult a doctor. Treatment is symptomatic, forced diuresis.
Symptoms caused by the action of pheniramine
Symptoms: convulsions, disturbances of consciousness, coma.
Treatment: Stop using the drug immediately and consult a doctor. It is recommended to lavage the stomach, take enterosorbents (activated carbon, hydrolytic lignin), intravenous or oral administration of the antidote acetylcysteine (if possible, in the first 10 hours after an overdose), and symptomatic treatment.
Drug interactions
Ethanol enhances the sedative effect of antihistamines (pheniramine), so its use should be avoided during treatment with Fervex®. In addition, ethanol, when used simultaneously with pheniramine, contributes to the development of acute pancreatitis.
Pheniramine enhances the effect of sedatives: morphine derivatives, barbiturates, benzodiazepines and other tranquilizers, neuroleptics (meprobamate, phenothiazine derivatives), antidepressants (amitriptyline, mirtazapine, mianserin), centrally acting antihypertensive drugs, sedatives belonging to the group of histamine H1 receptor blockers, baclofen, this not only increases the sedative effect, but also increases the risk of developing side effects of the drug (urinary retention, dry mouth, constipation).
The possibility of enhancing central m-anticholinergic effects when used in combination with other drugs with m-anticholinergic activity (other histamine H1 receptor blockers, tricyclic antidepressants, phenothiazine neuroleptics, antispasmodics and antiparkinsonian drugs with m-anticholinergic activity, disopyramide) should be taken into account.
When using the drug together with inducers of microsomal oxidation: barbiturates, tricyclic antidepressants, anticonvulsants (phenytoin), flumecinol, phenylbutazone, rifampicin and ethanol, the risk of hepatotoxicity (due to paracetamol included in the composition) significantly increases.
GCS, when used simultaneously, increases the risk of developing glaucoma.
Concomitant use with salicylates increases the risk of nephrotoxicity.
When used simultaneously with chloramphenicol (chloramphenicol), the toxicity of the latter increases.
Paracetamol enhances the effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.
Ascorbic acid increases the concentration of benzylpenicillin and tetracyclines in the blood, and at a dose of 1 g/day increases the bioavailability of ethinyl estradiol (including that included in oral contraceptives).
Ascorbic acid improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron), and can increase the excretion of iron when used simultaneously with deferoxamine.
Ascorbic acid reduces the effectiveness of heparin and indirect anticoagulants.
When used simultaneously with acetylsalicylic acid (ASA), the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%. Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.
Ascorbic acid increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.
Quinoline drugs, calcium chloride, salicylates, corticosteroids, when used for a long time, deplete ascorbic acid reserves.
When used simultaneously, ascorbic acid reduces the chronotropic effect of isoprenaline.
With long-term use or use in high doses, ascorbic acid may interfere with the interaction of disulfiram and ethanol.
In high doses, ascorbic acid increases the excretion of mexiletine by the kidneys.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Ascorbic acid reduces the therapeutic effect of neuroleptics - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.
Storage conditions for Fervex®
The drug should be stored out of the reach of children at a temperature of 15° to 25°C.
Shelf life of Fervex® Shelf life - 3 years. Do not use the drug after the expiration date indicated on the package.
Terms of sale The drug is available without a prescription.
Fervex price, where to buy
The price of Fervex for children starts from 250 rubles.
The price of Fervex (1 sachet) varies between 25-35 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Fervex powder for intravenous injection solution.
approx. with sah. raspberries 13.1g 8 pcs. Bristol-Myers Squibb/UPSA SAS RUR 366 order - Fervex powder for intravenous injection solution. approx. with sah. lemon 13.1g 8 pcs. Bristol-Myers Squibb/UPSA SAS
350 rub. order
- Fervex powder for intravenous injection solution. approx. without sugar lemon 4.95/13.1g 8 pcs. Bristol-Myers Squibb/UPSA SAS
RUB 214 order
- Fervex for children powder for injection solution for internal use. approx. raspberry 8 pcs.UPSA SAS
RUB 294 order
Pharmacy Dialogue
- Fervex sachets No. 8 with sugarBristol Myers
RUB 353 order
- Fervex bags No. 8 with raspberry sugarBristol Myers
RUB 343 order
- Fervex sachets No. 8 without sugarUPSA
RUB 211 order
- Fervex sachets No. 8 with raspberry sugarUPSA
RUB 359 order
- Fervex sachets No. 8 with sugarUPSA
RUB 344 order
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PaniPharmacy
- Fervex Fervex for adults.
package No. 8 France, BMS 137 UAH. order - Fervex Fervex for adults. raspberry package No. 8 France, UPSA
146 UAH order
- Fervex for children. package No. 8 Ukraine, BMS
138 UAH order
- Fervex Fervex for adults. used sugar package No. 8 France, UPSA
146 UAH order
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Description of the dosage form
Fervex
Raspberry with sugar:
powder from light pink to light beige. Blotches of dark pink color are allowed.
Lemon with sugar:
light beige powder with a characteristic odor. Brown inclusions are allowed.
Lemon without sugar:
light beige powder with a characteristic odor. Brown inclusions are allowed.
Fervex for children
Powder of light yellow color interspersed with yellow color with a characteristic odor.
