Acipol: recommendations, instructions, is it possible for pregnant women

What is the medicine Acipol for?

Indications for use can be found in the instructions. But this does not mean that a person can determine for himself the advisability of using the drug. Before your appointment, it is recommended to consult with a specialist who can prescribe an individual treatment regimen.

The medication is prescribed for various types of inflammatory reactions in the intestinal area. Such reactions include: dysentery, salmonellosis, adenoviral infections. Acipol is also prescribed for colitis. This medicine is used to treat dysbiosis.

Other indications include the need for long-term antibacterial treatment. The medicine is often used by people with weak immune systems. Acipol has proven itself well in correcting the condition of babies who were born prematurely. The drug is given to correct the gastrointestinal tract. It is in infancy that children often experience gas formation and pain in the abdomen.

Pharmacological action, pharmacodynamics and pharmacokinetics

Acipol belongs to the group of probiotics. It helps maintain the normal composition of microflora in the intestines, so that it functions well.

Kefir grains contain special polysaccharides that negatively affect the reproduction, growth and development of pathogenic microbes. This component also helps to increase the body’s immune strength and better resist foreign microorganisms.

Lactobacilli lower the pH in the intestines, making ammonia easier to bind with hydrogen and more quickly eliminated from the body during bowel movements. Therefore, it does not have time to have a negative impact on human health.

It is no secret that many important processes occur in the intestines: digestion of food, absorption of nutrients and nutrients, synthesis of vitamins. That is why it is so important that he works smoothly and has good motor skills and peristalsis. Acipol helps to normalize all intestinal functions and cope with dysbiosis, which leads to disorders.

Pharmacokinetics have not been described in the literature, because insufficiently studied.

How to use the medicine

Only a specialist can establish a drug treatment regimen. Treatment options depend on the severity of the problem and how the disease progresses. The capsule does not need to be cracked, but swallowed whole and washed down with plenty of drinking water.

If the patient has an acute intestinal disease, then you need to drink 4 capsules per day 25 minutes before meals. The average duration of the treatment course is a week. It is not recommended to take longer than 10 days, while other probiotics are used for a long time. This is a significant advantage of the composition.

Patients claim that the capsules are very convenient and easy to take, they are not large in size.

Acipol

* For dysbacteriosis

1. According to IQUIA Solutions LLC data for January – December 2021. The average retail price for the drug Atsipol is 352 rubles 84 kopecks

2. O. V. Molochkova, O. V. Kladova, A. A. Novokshonov, N. L. Valts, Yu. V. Kompaniets, N. L. Grishkevich. Prevention of antibiotic-associated diarrhea in children with a lactose-containing probiotic. Children's infections 2021, No. 4, S 37-411

3. List of studies conducted:

Novokshenov A. A., Molochkova O. V. et al. The use of a domestic probiotic containing Lactobacillus acidophilus for the treatment of acute intestinal infections and other pathologies in children. Therapy issues. Children's infections 2021, No. 1. Kladova O. V. et al. Preventive and therapeutic effectiveness of Acipol for antibiotic-associated diarrhea in children // Children's infections. – 2009. – No. 2. – P.44-47. Maev I.V. et al. Possibilities for the prevention of idiopathic antibiotic-associated diarrhea in adults. //Russian Journal of Gastroenterology, Hepatology, Coloproctology. – 2009. – No. 2. – pp. 75-78. Novokshonov A.A., Sokolova N.V., Berezhkova T.V., Sakharova A.A. Clinical effectiveness of the probiotic “Acipol” in the complex therapy of acute intestinal infections of bacterial, viral and viral-bacterial etiology in children // Children's infections. – 2009. – No. 4. – P. 61-65. Barmina O.S., Gorelov A.V., Usenko D.V., Ardatskaya M.D. Clinical and laboratory effectiveness of the multiprobiotic drug Acipol in the complex therapy of “invasive” acute intestinal infections in children // Infectious diseases. – 2009. – T.7, No. 1. – p.76-79. Bulanova I.A. Rationale for the use of lactose-containing probiotics for acute watery diarrhea in young children. Abstract. diss. Ph.D. honey. Sci. - Arkhangelsk, 2008. - 24 p. Yurlova E.V., Grigorovich M.S., Chastoedova I.A. State of enzyme secretion function in acute intestinal infections in children against the background of probiotic correction // Questions of practical pediatrics. – 2011. – T. 6, No. 3. - With. 97–101 Feklisova L.V. The use of lactose-containing probiotics: an assessment of the long-term use of Acipol in pediatric practice // Pediatrics. – 2007. – No. 2. – P. 123-127. Oleinichenko E.V., Mitrokhin S.D., Nonikov V.E., Minaev V.I. The effectiveness of acipol in the prevention of intestinal dysbiosis during antibacterial therapy // Antibiotics and chemotherapy. – 1999. – No. 1. – P.23-25. Volodko N.A., Konstantinova A.V., Klimenko N.Yu. Comparative effectiveness of drugs with different effects on the intestinal biocenosis in patients with respiratory tuberculosis // International Journal on Immunorehabilitation. - 2010. - T. 12. No. 2. - P. 120-121. Tselipanova E.E., Shebekova V.M., Savitskaya K.I., Rusanova E.V., Matveevskaya N.S. Clinical and immunological effectiveness of Acipol in children with acute respiratory infection // Almanac of Clinical Medicine. - 2002. - No. 5. - P. 260-264. Savenkova M.S., Afanasyeva A.A. Treatment of infections: antibacterial and probiotic effects // Pediatrics. - 2008. - No. 1. - P. 38-40. Gordeets A.V., Piskunova S.L., Chernikova A.A. Optimization of ARVI therapy in children during an influenza pandemic // Children's infections. - 2011.- No. 4. -P.52-56. Kushnareva M.V., Dementyeva G.M., Feklisova L.V., Chernogor I.N. The influence of eubiotic drugs on local intestinal immunity in premature infants with infectious and inflammatory diseases. // Pediatrics. - 2003. - No. 3. - P. 11-14. Novikova V.P., Gurova M.M., Tsekh O.M. Complex treatment using probiotics based on lactobacilli in children with chronic gastroduodenitis in remission. Advanced medical technology. - St. Petersburg, 2010. - 24 p. Nikitina L.V., Kalutsky P.V., Lazarev A.I., Besedin A.V. The effectiveness of the use of a probiotic (Acipol) in the complex therapy of chronic gastroduodenitis associated with H. Pylori in children //International Journal on Immunorehabilitation. - 2010. - T. 12. No. 2. - P. 220b-220b. Revnova M. O. Efficacy of Acipol in the treatment of children with celiac disease // Pediatrics. Consilium medicum. – 2009. – No. 1. – p.58-59. Oreshko L.S., Matveeva I.I., Ivanova O.I., Prokofieva N.A., Balagaeva M.S. On the issue of the immunomodulatory effect of the drug Acipol in complex pathogenetic therapy in patients with celiac disease // Diseases of the digestive organs. – 2009.- No. 2.- P.63-65. Kryuchkova T.A. et al. Clinical effectiveness of the probiotic Acipol in children suffering from atopic deramatitis. // Scientific bulletins of BelSU. Series: Medicine. Pharmacy. 2012. No. 22 (141). Shuster A.M. et al. Possibilities for optimizing the use of probiotics in clinical practice using the example of the domestic drug Acipol®. RMJ. 2009, No. 4. Kornienko E.A., Saburova A.V. Experience with the use of the probiotic Acipol in the complex therapy of gastroduodenitis with bacterial overgrowth syndrome in the small intestine. Children's infections. 2021.-N 3.-P.46-50.

Perlamutrov Yu.N., Olkhovskaya K.B., Ivashkina N.Yu., Shuster A.M., Martyanov V.A. The influence of probiotics on the functional state of the epidermal barrier of facial skin // Bulletin of Dermatology and Venereology. - 2008. - No. 4. - P. 80-83.

4. The drug Atsipol, capsules LS-001915 has been registered in the Russian Federation since 2006, according to the State Register of Medicines of the Russian Federation. Consumer loyalty has been confirmed according to data from Mediaskop JSC, January-June 2019

How to take Acipol for children

Children from 3 months to 3 years are prescribed 1 tablet per day. The contents of the capsule must be dissolved in water or milk. Some parents mix the powder with food. You can take the medicine again after 48 hours.

A child from 3 years of age is prescribed 3-4 capsules per day, preferably 30 minutes before meals. The medicine has many positive reviews for constipation in children. The composition of the drug is completely safe, has no toxic effect, and is perfectly absorbed by the body.

Indications and contraindications for the use of Acipol

Conditions for which the use of the drug is recommended:

• Acute intestinal infectious diseases caused by both gram- and gram+ microorganisms.
• Dysbiosis of an acute or chronic nature, which is accompanied by a decrease in the body's resistance to infections, a feeling of weakness, frequent constipation or diarrhea.
• Colitis, enteritis or enterocolitis.
• Irritable bowel syndrome.
• Allergy.
• Taking medications that cause disturbances in the normal intestinal microflora (for example, antibiotics).

The only absolute contraindication to taking Acipol is individual intolerance to the components of the drug.

Pharmacological properties of the drug Acipol

The drug is a mixture of a microbial mass of living antagonistically active acidophilic lactobacilli, lyophilized in a culture medium and heat-inactivated kefir grains containing a water-soluble polysaccharide. The contents of the capsule are dry biomass from light cream to cream color with a sour milk smell. Immunobiological and biological properties. The therapeutic effect of Acipol is determined by the live acidophilic lactobacilli present in it and the polysaccharide of kefir mushrooms. According to the mechanism of action, Acipol is a multifactorial drug with antagonistic activity against opportunistic microorganisms, which has a corrective effect on the intestinal microflora, increasing the overall reactivity of the body.

Drug analogues

The most common Acipol substitutes on the pharmaceutical market:

• Lactobacterin;
• Hilak Forte;
• Linux;
• Bifidumbacterin;
• Probifor;
• Colibacterin.

Analogues may be cheaper and more expensive, and also differ from Acipol in effectiveness. One way or another, only a specialist can select the most suitable and effective drug in your case.

Recommendations for use of Acipol

The drug should be prescribed by the attending physician; its dosage and frequency of administration depend on the characteristics and severity of the disease. The capsule is taken orally with a sufficient amount of liquid (water).

Most often, Acipol is recommended for use for intestinal diseases. In this case, it should be consumed 15-20 minutes before meals, 1 capsule 4 times a day. The course of treatment lasts from 5 to 8 days.

For preventive purposes, Acipol is prescribed for 2 weeks, 1 capsule per day. A repeated course is possible no earlier than after 1 month.

Special instructions for the use of the drug Acipol

The drug cannot be used:

• with a violation of the integrity of the packaging (cracked can);
• unmarked or unclearly marked;
• with altered physical properties (the integrity or shape of the capsule is damaged);
• in the presence of foreign inclusions;
• due to the expiration date of the drug.

Use during pregnancy and lactation: not studied. Impact on the ability to drive vehicles: no effect.

Indications for use of the drug Acipol

Dysbacteriosis and conditions leading to its development:

• acute intestinal infections (dysentery, salmonellosis, rotavirus gastroenteritis, etc.);
• chronic colitis, enterocolitis of infectious and non-infectious origin;
• long-term antibacterial therapy.

Dysbacteriosis and insufficient weight gain caused by:

• active antibiotic therapy for purulent-septic diseases in infants;
• chronic, protracted recurrent diseases of the respiratory system (bronchitis, pneumonia, including pneumocystis);
• atonic dermatitis and other allergic manifestations.

Prevention of dysbacteriosis:

• increasing the overall resistance of the body.