Zinerit powder for preparing a solution with a solution fl 30ml buy in Perm, description and instructions for use of the medicine, buy Zinerit powder for preparing a solution with a solution fl 30ml order on Apteka-ot

From this article you will learn:

drug Zenerit – composition, analogues,
detailed instructions for use,
reviews of Zinerit from dermatologists.

Zineryt for acne (Zineryt) is an antibacterial drug in the form of a solution for external use, containing the antibiotic erythromycin + zinc acetate complex. The drug is used to treat papulopustular acne (pimples). It is produced in the Netherlands, but the trademark on Zineryt® already belongs to (Denmark).

Zinerit is available in pharmacies without a doctor's prescription. It can be used in adults and children over 12 years of age. The antibiotic erythromycin is a long-known macrolide antibiotic and has been used to treat acne for more than half a century. This is due to its high activity against the bacteria Propionibacterium acnes and Streptococcus epidermidis, which are involved in the development of acne.

Reviews of the drug Zinerit from dermatologists have always been good, until recently, but recently there have been many reports of increasingly frequent cases of resistance of Propionibacterium acnes bacteria to macrolide antibiotics (according to the most authoritative textbook on dermatology, Fitzpatrick's Dermatology). Exactly the same data is reflected in many monographs and scientific works of Russian doctors.

How much does Zinerit cost in pharmacies:

The price for the drug Zinerit in pharmacies starts from 587 rubles (the price is indicated for 2021). Moreover, this is significantly lower than just a few years ago. Of course, the reason for this is the smaller number of prescriptions of this drug by dermatologists to their patients with acne. However, the drug cannot be considered completely irrelevant.

Composition of Zenerite

Zinerit contains two bottles with a complex of drugs and a solvent, intended for further mixing.
The first bottle of the drug complex includes 1200 mg of erythromycin and 360 mg of micronized zinc acetate dihydrate

– active ingredients.

The second bottle of solvent includes 8.36 ml of diisopropyl sebacate and 21.6 ml of ethanol - additional components.

1 milliliter of prepared lotion consists of 40 mg of erythromycin and 12 mg of micronized zinc acetate dihydrate

, as well as 250 mg of diisopropyl sebacate and 550 mg of ethanol.

Zenerit: composition and release form

Zinerit instructions for use tell us that the packaging of the drug consists of 2 bottles, as well as an applicator for applying the drug. The bottles must be mixed immediately before the 1st use. Keep in mind that after mixing the components of the drug, the finished solution can be stored (at a temperature of 15° to 25°C) and used for no more than 5 weeks.

Composition of bottles 1 and 2 –

Bottle No. 1 (dry mixture): antibiotic erythromycin - 1.2 g, zinc acetate - 360 mg.

Bottle No. 2 (solvent): ethanol – 17.1 ml, diisopropyl sebacate – 7.8 ml.

After diluting the dry mixture, we get 30 ml of the finished solution. Thus, the content of active components in 1.0 ml of solution will be –

antibiotic erythromycin – 40 mg,
zinc acetate – 12 mg,
ethanol – 0.55 g,
diisopropyl sebacate – 0.25 g.

→ Zinerit instructions for use (official, in FDF format)

Composition analysis –

Erythromycin belongs to the macrolide group of antibiotics. This antibiotic is especially effective against the bacteria Propionibacterium acnes and Streptococcus epidermidis, which play an important role in the development of inflammation and the formation of acne (papules and pustules). It should be noted that after application, only a very small part of erythromycin enters the systemic circulation (24stoma.ru).

Zinc helps reduce the production of sebaceous gland secretions (sebum), and also increases the sensitivity of pathogenic bacteria to erythromycin. In general, the addition of zinc to the composition allowed the manufacturer to reduce the number of cases of the formation of resistance of Propionibacterium acnes bacteria to erythromycin. Nevertheless, statistics clearly indicate that cases of resistance to erythromycin (even with zinc) are much more common than cases of resistance to drugs based on the antibiotic clindamycin.

Pharmacodynamics and pharmacokinetics

Zenerite is an erythromycin-zinc

a complex preparation characterized by
anti-acne effectiveness, which is manifested due to the combined effect of its active ingredients.
Effects of the antibiotic erythromycin

are aimed at suppressing the replication
of microorganisms (bacteriostatic effect) that cause acne
(
acne
):
epidermal streptococcus
(Streptococcus epidermidis) and
propionibacterium acne (Propionibacterium acne).
Zinc activity

lies in its
astringent
effect and reducing
the secretion of the sebaceous glands
(sebum).

The complex combination of all the ingredients of the drug creates good conditions for their penetration into the skin. The bulk of zinc binds to follicular epithelial cells

and does not penetrate into the systemic circulation.
A small fraction of erythromycin undergoes systemic absorption and is subsequently excreted from the human body.

Zinerit: analogues of the drug

An analogue of Zenerit for acne is cheaper - this is a drug from the Russian pharmaceutical company Arpimed, which produces a similar product - “2% erythromycin solution” for external use. However, this solution has only a 2% concentration of erythromycin, which corresponds to a dosage of 20 mg per 1 ml (this is 2 times lower than in the drug Zinerit), and in addition, the drug does not contain zinc. Accordingly, all this will mean a very rapid development of bacterial resistance to erythromycin.

Side effects -

In some cases, slight redness, dryness and flaking of the skin, tingling or burning may occur at the site of use of the drug. Such effects are normal and do not require discontinuation of the drug.

Contraindications for use –

You should not use Zinerit if you have a hypersensitivity (allergy) to erythromycin or other macrolide antibiotics, as well as to zinc or other components of the drug.

Use during pregnancy and breastfeeding –

The use of the drug during breastfeeding and pregnancy is possible if the recommended dosage of application is observed (no more than 0.5 ml per 1 application). The safety of the drug is due to the fact that erythromycin practically does not penetrate the skin and does not enter the systemic bloodstream. Studies have not revealed a negative effect of the drug on the fetus.

Zinerit, instructions for use

To use Zinerit correctly, you should mix the complex preparation

and
solvent
, which are in different bottles to extend the shelf life of the drug. Before mixing both components of the future lotion, you need to make sure that the shelf life of the drug and the integrity of both bottles correspond. Below are recommendations on how to make a Zenerit solution for acne at home, suitable for further direct use.

Preparation of lotion:

· first of all, you need to unscrew the caps (lids) from both bottles and at the same time keep the cap from the bottle with the complex of drugs;

· pour out the solvent

into a bottle of
powder
and screw the lid tightly on;

· immediately and thoroughly shake the mixture (for 60 seconds);

· remove the cap;

· remove the applicator

;

· insert applicator

into the neck of the lotion bottle and screw on the cap.

The solution prepared in this way is ready for use and can be stored at a temperature of 15-20°C for 5 weeks. To control the expiration date, you can write the date of manufacture on the lotion bottle.

Further instructions for the use of Zinerit involve its external application only. After unscrewing the cap from the bottle with the prepared lotion, you need to attach the applicator

to the affected areas of the skin and apply the drug in a thin layer, lightly pressing on the base of the inclined bottle.
Applications
made to previously cleaned areas of the skin with a frequency of 2 times every 24 hours (morning and evening).
The speed of application
depends on the force of pressure on the base of the bottle. The average single dose is 0.5 ml. The duration of the full treatment course can reach 10-12 weeks.

Photos before and after using Zenerit for 10 weeks:

The data on whether Zinerit helps against acne in a shorter period of use is purely individual. In some cases, an improvement in the condition of the patient's skin was observed after only 14 days of using the drug.

How to use the drug: instructions

Before the first procedure, it is necessary to properly prepare the solution:

unscrew the caps from the bottles;
pour the solvent into a container with antibiotic and zinc powder;
screw the bottle on and shake vigorously until all components are mixed;
open the preparation again and screw the applicator.

Apply the prepared solution onto the skin, moistening all inflammatory elements and nodules, then close tightly. After the first use, the drug remains active for about 5 weeks. It must then be disposed of. Store the liquid tightly closed, preferably in a cool place away from sunlight.

The solution is applied to the acne areas by placing the applicator on the skin and lightly pressing the bottle.

After moistening the rash with liquid, you need to refrain from water procedures and the use of cosmetics for 2 hours. After drying, Zinerite becomes transparent and is not visible visually, so you should not be afraid of additional cosmetic problems.
The procedure is repeated twice a day, applying the drug to cleansed skin. You can reapply Zenerite before going to bed.
Duration of treatment: from 4 to 10 weeks; if the rash is eliminated earlier, the course can be completed ahead of schedule. Too long use can provoke the development of microbial resistance to macrolide antibiotics.

When using the solution, it is important to be careful not to allow it to come into contact with the mucous membranes of the eyes and skin of the lips, otherwise severe irritation may occur.

special instructions

After applying the drug to the skin and completely drying, the lotion becomes invisible.

With long-term use of Zenerit, it is theoretically possible to develop cross-resistance

in relation to other
macrolides
,
Clindamycin
and
Lincomycin
.

When carrying out applications

precautions should be taken to prevent application of the drug to
the mucous membranes of the eyes
,
nose and mouth
, in order to avoid
irritation
and/or
burns
.

Zinerit: reviews from a dermatologist

On the drug Zinerit for acne - reviews from dermatologists and researchers at medical universities increasingly boil down to the fact that every year more and more strains of the bacteria Propionibacterium acnes are discovered that are insensitive to this drug. The reason for this is largely due to the over-the-counter availability of the drug (this means the possibility of advertising on TV), which potentiates the uncontrolled use of this drug by patients - as a means of self-treating acne at home.

You may suspect Propionibacterium acnes bacteria are resistant to Zinerit if you do not notice an effect from therapy within 2 weeks of use. The downside is the possibility of developing cross-resistance - when the development of resistance to erythromycin can automatically lead to microflora resistance to other antibiotics, for example, clindamycin.

There is a large list of scientific papers on Propionibacterium acnes resistance to erythromycin. For example, Barinova A.N. “Modern methods of treatment and rehabilitation of patients with acne vulgaris” (Federal State Budgetary Educational Institution of Higher Education “North-Western State Medical University named after Mechnikov” of the Ministry of Health of Russia, St. Petersburg). We quote: “The use of erythromycin is currently limited due to the large number of resistant strains of Propionibacterium acnes.” And there are a lot of studies with the same conclusions.

Important: In addition, we do not recommend using this medication for patients with dry or sensitive skin. The drug contains ethyl alcohol as a solvent, therefore we will get even more drying of the skin. The drug is better suited for patients with oily skin.

Note!

The description of the drug Zinerit on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Side effects of Zinerit

On the part of the immune system, the following hypersensitivity reactions can very rarely be observed:

rash;
angioedema;
labored breathing;
swelling of the mouth, lips or tongue.

On the part of the skin and subcutaneous tissue, the following may rarely be observed:

itching;
dry skin;
peeling.

You may also notice burning, skin irritation and redness. But these effects are minor and temporary.

Zinerite powder for preparing a solution with a solution fl 30 ml