Ultraproct rectal suppositories No. 12 - Instructions

Compound

Pharmacological properties of the drug Ultraproct

Fluocortolone has anti-inflammatory, antiallergic and antipruritic effects. As a result of the drug's action, capillary dilatation, intercellular edema and tissue infiltration are reduced, and capillary proliferation is inhibited. The drug Ultraproct contains two fluocortolone esters, the onset of the main action of which occurs at different times, which allows you to achieve a quick effect and maintain it for a long time (two-phase action). Cinchocaine as a local anesthetic reduces pain. Due to the different lipophilicity and molecular weight of fluocortolone pivalate and fluocortolone caproate diffuse at different rates into the site of inflammation, which leads, on the one hand, to a rapid onset of action, and on the other, to an increase in the duration of action. It is assumed that after topical application, both esters are hydrolyzed to free fluocortolone and corresponding acids at the level of the perianal skin or rectal mucosa. Studies of formulations similar to Ultraproct have shown that less than 15% of the applied dose of fluocortolone pivalate is absorbed rectally. Adsorbed fluocortolone is metabolized in the liver, most metabolites are excreted in the urine. Like corticosteroids, cinchocaine has a local analgesic effect. Analgesic effective plasma levels of cinchocaine are not a necessary prerequisite. According to assumptions, the adsorbed dose of cinchocaine is small to detect side effects if Ultraproct is used according to the instructions. After absorption, cinchocaine is biotransformed into a certain number of metabolites. Even under the assumption of complete adsorption, systemic effects can be excluded when using both forms of the drug according to the instructions due to the low dosage of the active ingredients of the drug.

Pharmacodynamics

The combined drug has an anti-inflammatory, antipruritic, antiallergic, local anesthetic effect.

Fluocortolone

The drug contains two forms of fluocortolone, which ensures a rapid onset of action and a longer duration. Fluocortolone, when exposed locally, prevents the marginal accumulation of neutrophils, which leads to a decrease in inflammatory exudate and the production of lymphokines, inhibition of macrophage migration, and a decrease in the processes of infiltration and granulation.

Cinchocaine

Cinchocaine is a local anesthetic. Pain relief is achieved by suppressing the formation and conduction of nerve impulses along afferent nerve fibers by depolarizing sodium channels.

Analogs

Level 4 ATC code matches:
Betiol

Olestesin

Proctosedyl

Relief

Anuzol

Posterisan Forte

Posterisan

Bezornil

Procto-Glyvenol

Glivenol

Proctosan

Hepazolon

Analogues of Ultraproct are represented by local drugs of other groups used in proctology for the treatment of similar pathological conditions:

• Anuzol;
• Bezornil;
• Gepatrombin G;
• Betiol;
• Hemorol;
• Doloproct;
• Posterisan;
• Neo-Anuzol;
• Procto-glivenol;
• Baliz;
• Proctosan;
• Relief;
• Proctosedyl;
• Symetrid , etc.

Pharmacokinetics

Fluocortolone pivalate and fluocortolone hexonate, having different lipophilicity and molecular weight, diffuse at different rates. As a result, on the one hand, a faster effect is achieved, and on the other, its longer duration.

Fluocortolone is hydrolyzed by esterases, enzymes at the site of inflammation to form fluocortolone, 11-ketofluocortolone and trimethylacetic acid. T1/2 from plasma of fluocortolone and its metabolites after rectal administration is approximately 1.3 and 4 hours, respectively.

Fluocortolone is excreted from the body in the form of metabolites mainly by the kidneys.

Ultraprokt price, where to buy

The average price of Ultraproct ointment 10 grams varies around 550 rubles, the average price of Ultraproct in suppositories No. 10 is 620 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in KazakhstanKazakhstan

LuxPharma* special offer

• Ultraproct candles 12 pcs
  2200 rub. order
• Ultraproct ointment 30g

  2150 rub. order

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Use during pregnancy and breastfeeding

A number of epidemiological studies suggest a possible increased risk of developing cleft palate in newborns whose mothers received oral corticosteroids in the first trimester of pregnancy. There is insufficient data on the use of local corticosteroids during pregnancy, but in this case the likelihood of adverse effects is very low due to the minimal bioavailability of corticosteroids when applied topically.

Ultraproct ointment and suppositories should be prescribed with caution to pregnant women in the 2nd and 3rd trimester. When prescribing to pregnant and lactating women, it is necessary to compare the expected benefits of treatment for the mother with the possible risk to the fetus and infant.

When prescribed by a doctor during pregnancy and lactation, the drug should be used for a short time.

Contraindications

The use of Ultraproct is contraindicated in:

• manifestations of syphilis , tuberculosis in the area where the drug is used;
• pregnancy (in the first trimester);
• manifestations of diseases of viral etiology (including chickenpox , response to vaccination ) in the area where the drug is used;
• increased personal sensitivity to fluocortolone , cinchocaine or other drug ingredients.

Also, Ultraproct is not recommended for use in childhood and adolescence (due to the lack of reliable clinical data).

Directions for use and doses

Ultraproct is recommended for use after defecation. Before using the drug, you should perform hygiene of the anus (anus).

Rectal ointment

Typically, the ointment should be applied 2 times a day, on the first day for rapid relief of symptoms - up to 4 times.

Squeeze a small amount of ointment (about the size of a pea) onto your finger and lubricate the area around the anus and inside the anal ring. To overcome sphincter resistance, you need to apply the ointment with your fingertip. Before introducing the ointment into the rectum, you must screw the attached applicator onto the tube and insert it into the anus. Then, pressing lightly on the tube, squeeze a small amount of ointment into the rectum.

Rectal suppositories

Typically, you should use 1 supp daily, injecting it deep into the rectum. In severe cases, on the first day 1 supp. is administered 2 or 3 times.

For severely inflamed and therefore painful hemorrhoids, it is recommended to start treatment with ointment.

Protruding hemorrhoids should be generously lubricated with ointment, gently pushing them back with your finger.

If the suppositories have softened under the influence of heat, they should be placed in cold water without removing the packaging, then they will return to their previous shape.

There is usually rapid improvement, but this should not be a reason to stop treatment too soon. To avoid relapses, you should continue to use Ultraproct for at least 1 more week, although with less frequency (ointment - 1 time per day or 1 supp. - every other day), even with complete disappearance of symptoms. However, the duration of treatment should not exceed 4 weeks.

special instructions

If the patient has a concomitant fungal infection, he should be prescribed additional antimycotic therapy .

When using any of the dosage forms of the drug, it is necessary to exclude the possibility of contact with the eyes and/or ingestion.

After using suppositories or ointments, the patient is advised to wash their hands with special care.

To give the candles their previous solid form, lost under the influence of heat, the suppositories in the package must be immersed in cold water.

Overdose

In accordance with the results of studies of the acute toxicity of fluocortolone and cinchocaine esters, acute intoxication is unlikely to occur with a single rectal or perianal use of Ultraproct, even with an accidental overdose. In case of accidental oral administration of the drug (for example, when swallowing several grams of ointment or several suppositories), it is likely that the side effects of cinchocaine are mainly of a somatic nature, which, depending on the dose, can manifest as severe cardiovascular symptoms (decreased cardiac activity up to cardiac arrest) , and symptoms of dysfunction of the central nervous system (convulsions, inhibition of respiratory function up to respiratory arrest).

Reviews about Ultraprokt

Reviews of Ultraproct ointment, as well as reviews of Ultraproct suppositories, are either positive or neutral. In other words, the effectiveness of the drug receives either a positive assessment (including the rapid onset of action of the drug and long-term remission of the disease), or indifferent (including insufficient or zero effectiveness of treatment ). In both cases, mentions of any side effects are extremely rare.

Such a discrepancy in assessing the effectiveness of the drug most likely arises due to the formation of proctological pathologies ( anal fissures , hemorrhoids , etc.) for various reasons and due to various external or internal influences ( traumatic injuries , poor nutrition metabolic disorders , etc. .). In this regard, there is no single effective treatment that alleviates the patient’s painful condition. If treatment is necessary, the patient should consult a proctologist to find out the exact reasons for the development of the pathology observed in him and to select an effective therapeutic agent in this case.

Manufacturer

Intenlis GmbH, Germany.

10589, Berlin, st. Max-Dorn, 10, Germany.

produced by Intendis Manufacturing SpA, Italy.

20090, Segrate, Milan, Italy, st. E. Sheringa, 21.

Intendis GmbH, Germany.

Max-Dohrn-Str. 10, D-10589 Berlin, Germany.

manufactured by Intendis Manufacturing SpA, Italy, ViaE. Schering, 21. 20090 Segrate, Milano, Italy.

Additional information can be obtained at:

107113, Moscow, 3rd Rybinskaya st., 18., building 2.

Tel.; fax:+7.

Therapeutic effects and indications

The therapeutic effect of the drug is ensured by the characteristics of the components that make up it. Fluocrotolone is a glucocorticosteroid hormone and has anti-inflammatory and anti-edematous effects.

Cinchocaine is a local anesthetic that inhibits the conduction of impulses along nerve fibers.

For external hemorrhoids, it is recommended to use the product in the form of an ointment, since suppositories can injure hemorrhoids.

Indications for the use of Ultraproct include proctitis, hemorrhoids, fungal infections of the anus and rectum, cracks and irritations of the mucous membrane. Suppositories quickly and effectively eliminate the symptoms of pathologies, reduce discomfort, eliminate inflammation and alleviate the general condition of patients.

The list of contraindications includes fungal and viral infections at the site of application, and side effects include skin itching, burning, dry skin and allergic reactions. Ultraproct is considered an effective and fairly safe drug, but requires caution when used, especially if the patient requires long-term treatment.