Pharmacological properties of the drug Nifuroxazide Richter
Pharmacodynamics . Nifuroxazide is an intestinal antiseptic, a derivative of 5-nitrofuran; active against most pathogens of intestinal infections (including mutant strains resistant to other antimicrobial agents): gram-positive ( Staphylococcus ) and gram-negative ( Enterobacteriaceae : Escherichia, Citrobacter, Enterobacter, Klebsiella, Salmonella, Shigella, Proteus, Yersinia ), as well as Vibrio cholerae . Inactive against bacteria of the genus Pseudomonas and the genus Proteus (species Proteus inconstans ), as well as strains of subgroup A of the species Providentia alcalifaciens . It is assumed that the drug inhibits the activity of dehydrogenases and disrupts protein synthesis in pathogenic bacteria. At moderate therapeutic doses it has bacteriostatic activity, and at higher doses it has a bactericidal effect. The effect appears from the first hours of administration. In therapeutic doses, it practically does not disturb the balance of the saprophytic flora of the large intestine; does not cause the development of resistant strains of pathogenic microorganisms and cross-resistance of bacteria to other antimicrobial agents, which allows, if necessary, in the case of generalized infections, to prescribe it in complex therapy with systemic drugs. In case of intestinal infections of viral origin, it prevents the development of bacterial superinfection. Pharmacokinetics. After oral administration, it is practically not absorbed into the gastrointestinal tract, creating a high concentration of the active substance in the intestine. Trace concentrations of the drug are determined in blood plasma; a small amount is detected in urine unchanged. Due to these pharmacokinetic properties, the drug has an exclusively enteral antiseptic effect, does not have systemic antibacterial activity, and does not cause general toxic effects; excreted from the body with feces.
Use of the drug Nifuroxazide Richter
Tablets The drug is taken orally. Adults and children over 6 years of age are prescribed 2 tablets 4 times a day at equal intervals (every 6 hours). The drug is taken regardless of meal time. The course of treatment is 5–7 days. For children under 6 years of age, it is recommended to prescribe the drug in the form of a suspension. Suspension The drug is taken orally. Before use, the bottle must be shaken thoroughly until a homogeneous suspension is obtained. 5 ml (1 teaspoon) contains 220 mg of nifuroxazide. Children aged 2–6 months are prescribed 2.5–5 ml (1/2–1 teaspoon) 2 times a day; from 6 months to 6 years - 5 ml (1 teaspoon) 3 times a day; over 6 years old - 5 ml (1 teaspoon) 4 times a day; adults - 5 ml (1 teaspoon) 4 times a day.
Buy Nifuroxazide suspension 220mg/5ml 90ml in pharmacies
Instructions for use Nifuroxazide Susp. 220mg/5ml 90ml Dosage forms suspension 200mg/5ml 90ml Synonyms Stopdiar Ecofuril Ersefuril Group Antimicrobial - nitrofuran derivatives International nonproprietary name Nifuroxazide Composition Active substance: Nifuroxazide. Manufacturers Gedeon Richter (Hungary) Pharmacological action Antibacterial. Blocks dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and a number of other biochemical processes in the microbial cell. Destroys the microbial wall or cytoplasmic membrane, reduces the production of toxins by microorganisms. Activates the immune system: increases phagocytosis of microorganisms and complement titer. After oral administration, it is practically not absorbed and has an effect in the intestinal lumen. Effective against most gram-positive (staphylococci, streptococci, clostridia) and gram-negative (Escherichia coli, salmonella, shigella, klebsiella, enterobacter, vibrio cholerae) pathogenic intestinal bacteria. When infected with enterotropic viruses, it prevents the development of bacterial superinfection. The type of effect (bactericidal or bacteriostatic) depends on the intraintestinal concentration. In acute diarrhea of bacterial etiology, it restores intestinal eubiosis. Side effects Allergic reactions. Indications for use
Acute intestinal infections occurring with diarrhea; chronic intestinal infections - colitis and enterocolitis; dysbacteriosis (disturbance of intestinal microflora) - as part of complex treatment; prevention of infectious complications during operations on the gastrointestinal tract.
Contraindications
1. Individual hypersensitivity to the drug (allergy).
2. The child is under two months old. Method of administration and dosage Nifuroxazide is taken orally, without chewing the tablet, but swallowing it whole. Drink with clean water. The suspension also needs to be washed down. You can take the medicine either before or after meals - it doesn’t matter. However, equal time intervals must be observed between doses.
Nifuroxazide tablets are usually prescribed in the following dosage: Adults - 2 tablets. 4 times a day (i.e. every 6 hours). The dosage of the drug for children over 6 years of age is the same as for adults. Nifuroxazide suspension is prescribed to adults, one measuring spoon (5 ml) 4 times a day. Children over 6 years old receive the medicine in the same dosage. The course of treatment is 5-7 days.
special instructions
During treatment with Nifuroxazide, the patient must follow a diet excluding raw vegetables and fruits, juices, as well as spicy, fatty and indigestible foods. You need to drink a lot of liquid (mineral water, weak unsweetened tea, saline solutions). You should not drink alcohol during treatment, because... Nifuroxazide in combination with alcohol can cause increased diarrhea, vomiting, abdominal pain, difficulty breathing, increased heart rate, a rush of blood to the upper half of the body, and a feeling of fear. Nifuroxazide does not affect the speed of the patient's reactions and ability to concentrate.
Nifuroxazide - instructions for use for children
Features of the use of the drug in pediatrics In pediatric practice, Nifuroxazide is widely used and is considered one of the best medicines for the treatment of intestinal infections. A big plus is the fact that Nifuroxazide does not destroy normal intestinal microflora and, therefore, does not cause the development of dysbiosis.
The second advantage is the rapid action of the drug: the therapeutic effect appears within the first few hours after taking the medicine. And of course, it is important to have a dosage form that is convenient for children - a suspension with a pleasant taste.
Nifuroxazide in children Diarrhea (diarrhea) caused by acute intestinal infections; Intestinal dysbiosis; Prevention of infections during intestinal surgery. Chronic colitis and enterocolitis in children are rare, but if such a pathology exists, then Nifuroxazide can be used to treat it. Contraindications
1. Prematurity.
2. Under two months of age.
3. Allergy to the drug.
Dosage
The dosage of Nifuroxazide suspension for children aged 2-6 months is 2.5 ml or 5 ml twice a day (i.e. every 12 hours). The doctor chooses the dose individually, depending on the severity of the disease. For children from 6 months to 6 years, the dosage is increased: 5 ml of Nifuroxazide suspension three times a day (every 8 hours). For children over 6 years of age, the dosage of the drug is the same as for adults: 5 ml of Nifuroxazide suspension four times a day (every 6 hours). Special instructions In young children (2 months - 1 year), before starting treatment with Nifuroxazide, it is necessary to exclude a congenital disease associated with a deficiency of enzymes that break down sucrose.
Nifuroxazide during pregnancy No studies have been conducted on the use of Nifuroxazide during pregnancy and lactation. In clinical practice, there have been no cases of negative effects of the drug on fetal development. Therefore, treatment of pregnant women with Nifuroxazide is allowed, but only as prescribed by a doctor who evaluates the ratio of the possible benefits of using the drug to the possible risk of the drug affecting the fetus.
Special instructions for the use of the drug Nifuroxazide Richter
The drug is not prescribed as monotherapy for the treatment of intestinal infections complicated by septicemia. If there are symptoms of dehydration, it is necessary to carry out rehydration therapy in combination with treatment (for adults - about 2 liters of fluid per day). Alcohol increases the body's sensitivity to the drug and can provoke a disulfiram-like reaction, expressed by diarrhea, vomiting, abdominal pain, skin flushing, a feeling of heat on the face and upper body, noise in the head, difficulty breathing, tachycardia, and a feeling of fear. Drinking alcoholic beverages while taking Nifuroxazide is contraindicated. Nifuroxazide does not affect the psychomotor reactions of the body. Under the supervision of a doctor, the drug can be prescribed during pregnancy and lactation. During treatment, you should adhere to a certain diet: do not consume raw fruits and vegetables, juices, spicy and indigestible foods.
Nifuroxazide tablets p/o 100 mg No. 10x3
Name
Nifuroxazide tablet 100 mg No. 30
Description
Yellow film-coated tablets, round with a biconvex surface.
Main active ingredient
Nifuroxazide
Release form
pills
Dosage
100 mg
Pharmacological properties
Pharmacodynamics
Nifuroxazide is an intestinal antiseptic, a derivative of 5-nitrofuran, has a local antibacterial effect against gram-positive (Staphylococcus family) and gram-negative (Enterobacteriaceae family: Escherichia spp., Citrobacter spp., Enterobacter spp., Klebsiella spp., Salmonella spp.) bacteria. Nifuroxazide does not exhibit antibacterial activity against bacteria of the species Proteus vulgaris, Proteus mirabilis and Pseudomonas aeruginosa. Nifuroxazide does not destroy saprophytic intestinal flora. Does not cause the emergence of strains resistant to nifuroxazide. The exact mechanism of action is unknown. Nifuroxazide can inhibit the activity of dehydrogenases and disrupt protein synthesis in bacterial cells. Efficiency does not depend on pH in the intestinal lumen.
Pharmacokinetics
Absorption of nifuroxazide is extremely low, provided there are no changes in the intestinal mucosa. Excreted by the intestines.
Indications for use
Treatment of acute diarrhea of bacterial origin in the absence of signs of invasion (for example, deterioration in general condition, fever, signs of toxic infection). Concomitant rehydration therapy is determined by the severity of diarrhea, age, gender, body weight of the patient, as well as the presence of concomitant diseases.
Directions for use and doses
The medicine is intended for adults and children over 6 years of age. Take the tablets orally, without chewing, with a drink? glasses of chilled boiled water. Adults: 800 mg per day (4 tablets 2 times a day; or 2 tablets 4 times a day). Children over 6 years old: 600-800 mg per day (2 tablets 3 times a day; or 2 tablets 4 times a day). For children under 6 years of age, a different dosage form of nifuroxazide should be used. The duration of use of nifuroxazide is limited to 7 days.
Use during pregnancy and lactation
It is not recommended to use the drug during pregnancy and lactation.
Precautionary measures
During treatment, it is necessary to replenish fluid loss orally or parenterally (depending on the patient’s condition). Drinking alcoholic beverages during treatment with nifuroxazide may cause a disulfiram-like reaction. Nifuroxazide is not prescribed as monotherapy for the treatment of intestinal infections accompanied by septicemia. In the case of infectious diarrhea with clinical manifestations of generalized infection, it is necessary to prescribe systemic antibacterial drugs. If symptoms of dehydration appear during treatment with the drug, it is necessary, depending on the clinical condition of the patient, to carry out rehydration therapy (for adults - about 2 liters of fluid per day). In case of ongoing diarrhea after 3 days of treatment, it is necessary to carry out an in-depth diagnosis, the purpose of which is to determine the cause of the symptoms, and consider starting antibiotic therapy. If hypersensitivity reactions occur, such as shortness of breath, skin rash, itching, you should stop using the drug. Nifuroxazide should be used in compliance with a strict diet, excluding juices, raw fruits and vegetables, spicy and indigestible foods from the diet.
Interaction with other drugs
When treating with nifuroxazide, simultaneous administration of oral medications should be avoided due to the strong adsorption properties of the drug. Because Nifuroxazide is not absorbed from the gastrointestinal tract; the possibility of interaction with other systemic drugs is unlikely. It is not recommended to take the drug with medications that can cause withdrawal symptoms or antidepressants.
Contraindications
- children under 6 years of age;
- hypersensitivity reactions to 5-nitrofuran derivatives;
- pregnancy.
Compound
One tablet contains: active ingredient? nifuroxazide - 100 mg; excipients: anhydrous colloidal silicon dioxide, gelatin, talc, magnesium stearate, potato starch, opadry II (contains: polyvinyl alcohol, partially hydrolyzed; macrogol 3350 (polyethylene glycol); talc; titanium dioxide E 171; aluminum varnish based on yellow quinoline E 104 ; iron oxide yellow E 172).
Overdose
Symptoms of drug overdose are not described. In case of overdose, gastric lavage and symptomatic treatment are recommended.
Side effect
Nifuroxazide is usually well tolerated. However, the following adverse reactions may occur. From the hematopoietic and lymphatic systems: one case of granulocytopenia has been described. From the gastrointestinal tract: in cases of individual hypersensitivity to nifuroxazide, abdominal pain, nausea and exacerbation of diarrhea may occur. If these symptoms of minor intensity appear, there is no need to use special therapy or discontinue the drug. If the above symptoms are significantly intense, you should stop taking the drug. In the future, the patient should not take nitrofuran derivatives. From the skin and subcutaneous tissue: allergic reactions may develop (skin rash, urticaria, Quincke's edema, anaphylactic reactions). If hypersensitivity reactions develop, such as shortness of breath, skin rash, itching, you should stop taking the drug.
Storage conditions
In a place protected from light and moisture, at a temperature from 15 ° C to 25 ° C. Keep out of the reach of children.
