What are Trigan-D tablets for? Instructions for use, effect of the drug, price, overdose, reviews

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Attention! The material contains information about substances, the use of which can cause serious harm to your health!

Article prepared by an expert

Egorova Yulia Viktorovna

Psychologist, diagnostician, author of rehabilitation programs for addicts. Member of the Association of Cognitive Behavioral Psychotherapy. More than 7 years of experience working with addicts and their families.

Reading time: 4 minutes

Read in the article:

Purpose of the drug
Use of Trigan-D by drug addicts
Signs of intoxication
How addiction develops
Health implications
First aid and addiction treatment

The drug Trigan-D is a pain reliever, but in case of overdose it has side effects that attract drug addicts. The easy availability of the drug for different segments of the population has caused a surge in consumption, which is why many experts are calling for the drug to be classified as a narcotic. What effect Trigan-D has on the human body, how addiction develops and how to treat it, read our article.

Pharmacodynamics and pharmacokinetics

There is no information about Trigan-D on Wikipedia, and the interested category of people have questions “Trigan-D, what is it?” or “What is Trigan-D?”

The first component is paracetamol : it has an antipyretic, analgesic and weak anti-inflammatory effect. Inhibits cyclooxygenase of the first and second types in the nervous system and other tissues, as a result, the synthesis of prostaglandins - mediators of pain, regulation of body temperature and inflammation - stops.

The second component is dicycloverine hydrochloride : it has a small non-selective m-anticholinergic and myotropic antispasmodic effect on the smooth muscle cells of internal organs. In therapeutic doses, it has a relaxing effect on smooth muscles, not accompanied by atropine-like side effects.

The combined use of these two components allows for relaxation of the smooth muscle tissue of internal organs and relief of pain.

Pharmacokinetics

Well absorbed from the intestines. The maximum concentration in the blood is recorded after one hour. Paracetamol is transformed in the liver to form a number of metabolites, one of them N-acetyl-benzoquinomine can have a damaging effect on the kidneys and liver.
80% of the drug is excreted by the kidneys and in small amounts with feces.

How is the mephedrone test performed?

Medical examination for mephedrone is carried out in two stages.

First, rapid tests based on the immunochromatography method are carried out. They give a qualitative result: either positive or negative. The accuracy of such analyzes is not very high, but they are time- and labor-efficient, which makes it possible to examine large groups of people. Thanks to test strips, diagnostics can be carried out outside the laboratory.
If the preliminary analysis gives a positive result, then the person is sent for a confirmatory study. It is carried out in laboratories, and the biological material can be not only urine, but also blood. The methods used are thin layer chromatography, gas-liquid chromatography and chromatography-mass spectrometry. The results show the concentration of mephedrone in the biomaterial sample.

Indications for use

Indications for use (for which Trigan-D tablets are usually used):

spasm of smooth muscle internal organs;
algomenorrhea;
hepatic, intestinal or renal colic ;
neuralgia;
toothache or headache ;
myalgia;
fever in infectious and inflammatory diseases .

Contraindications

Sensitization to paracetamol or dicycloverine .
Stomach or duodenal ulcer.
Intestinal diseases complicated by obstruction.
Hypovolemic shock.
Reflux esophagitis.
Myasthenia gravis.
Lactation and pregnancy .
Age less than 15 years.

The components of the drug in patients with liver or kidney disorders, glucose-6-phosphate dehydrogenase , glaucoma , blood diseases, hyperbilirubinemia, viral hepatitis, alcoholism and in old age can worsen the course of these diseases, from which Trigan-D tablets should be used in this category of people with extreme caution.

Symptoms of a mephedrone addict

Signs of using mephedrone are the following symptoms:

facial redness;
huge icons that almost cover the iris of the eye;
very cold and sweaty hands;
slight trembling;
fast pulse;
refusal of food.

Doctors also note that within 3-5 days after taking it, a syndrome of a specific odor of sweat and urine occurs.

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At the beginning of using mephedrone, the addict manages to successfully hide his new addiction, but very quickly the behavior and appearance of the addict begins to raise suspicions for the following reasons:

Under the influence of mephedrone, the addict does not want to sleep or eat. If he uses the drug for several days, his relatives will clearly suspect something is wrong.
The addict becomes very active and talkative. He expresses deep interest in each topic, jumping sharply from one to another.
There are also external signs: shiny eyes, crazy eyes and dilated pupils. Muscle spasms may begin on the face. Behavior is overly emotional and fussy.

Side effects

Reactions from the digestive system: distortion of taste, stomach pain, decreased appetite, increased levels of liver enzymes , constipation, hepatonecrosis.
Reactions from the nervous system: dizziness , drowsiness , agitation and disorientation.
Allergic reactions: Quincke's edema , rash , urticaria , Stevens-Johnson syndrome, itching , Lyell's syndrome.
Reactions from the hormonal system: hypoglycemia.
Reactions from the excretory system: interstitial nephritis, urinary retention, pyuria , papillary necrosis , decreased potency.
Reactions from the hematopoietic system: methemoglobinemia, hemolytic anemia.
Reactions from the vision: mydriasis, paralysis of accommodation, blurred vision, increased intraocular pressure.

Trigan-D tablets, instructions for use (Method and dosage)

Instructions for use on Trigan-D recommend taking the drug orally, 1 tablet up to three times a day. The largest single dose is two tablets, the daily dose is four tablets. Duration of administration is no more than five days when used as an analgesic and three days when used as an antipyretic.

It is not recommended to exceed the daily dose, since an overdose of the drug causes liver failure, for which Trigan-D (if it is necessary to increase the dose or increase the standard duration of treatment) must be used under the supervision of a physician.

Types of mephedrone

Myofedrine is most often distributed as a fine powder called flour or crystals. But you can also find the following release forms:

In the form of tablets or capsules in a variety of colors (to attract the interest of young people),
Solutions that are administered intravenously or intramuscularly.

Drug Flour

The most common form in which mephedrone is sold is small packets of fine-grained off-white, grayish or yellow powder. When compressed, the powder can be collected into lumps. Powdered mef is usually called flour due to its similar shape. In this form, it is used for inhalation, dissolved in liquids or rubbed into the gums.

Drug Meow

Meow is a slang name that combines all types of the drug Mephedrone. The full name of the chemical composition - methylmethcathinone in the language of drug addicts took the form "meow-meow cat" or abbreviated - "meow". This word is used to avoid arousing suspicion among others, including when speaking within earshot of family members or in the company of others. This is where the slang word “meow” comes from, meaning “to take a dose of mephedrone.”

Drug Myth

Mephedrone sachets may also contain a powder with large grains, similar to washing powder. For this comparison, this form received its name “Myth”.

Drug Battery

The figurative name “Battery” was given to tablets with mephedrone, since after their use there is a sharp surge of energy and good mood. To enhance the effect or obtain new sensations, other narcotic drugs, for example, amphetamines, are added to the composition. Mephedrone tablets are often sold in nightclubs and other places where young people have fun. To increase interest, they are made multi-colored and given the most unusual shapes.

Drug Crystal

Mephedrone can be sold in the form of small clear or cloudy crystals, similar to sugar grains.

Overdose

Overdose of Trigan-D, symptoms: tachypnea, tachycardia, fever, convulsions, agitation, pain in the stomach, decreased appetite, thrombocytopenia, anemia, nephrotoxicity, hemolytic or aplastic anemia, pancytopenia, methemoglobinemia, hepatonecrosis.

Therapy: stop using the drug, perform gastric lavage, take adsorbents , agents that stimulate the formation of glutathione (for example, acetylcysteine ) and activate conjugation ( methionine ).

Interaction

The effects of dicycloverine are stimulated by first class antiarrhythmic drugs benzodiazepines, narcotic painkillers, MAO inhibitors, sympathomimetics, nitrates, nitrites, tricyclic antidepressants.

Dicycloverine increases the level of dioxin in the blood.

Enhancers of microsomal oxidation ( ethanol, barbiturates, rifampicin, tricyclic antidepressants ) stimulate the synthesis of hydroxylated metabolites in the liver, this can lead to the development of severe intoxication even with mild overdoses of paracetamol .

Inhibitors of microsomal oxidation reduce the possibility of hepatotoxicity .

Adrenergic stimulants and anticholinergic drugs increase the risk of unwanted effects.

Paracetamol activates the action of indirect anticoagulants.

Consequences of using mephedrone: harm to the body

Negative effects from using mephedrone include:

Changes in heart rate (palpitations).
Sleep disorder (insomnia).
Short-term amnesia.
Spasms in the muscles of the jaw and legs.
Narrowing of capillaries and blood vessels.
Pain, swelling, bleeding from the throat and nose.
Severe rhinitis (runny nose), sinusitis.

Due to the constantly changing formulas of mephedrone, it is difficult to test it and find out what kind of toxic effects the drug has.

Analogs

Level 4 ATC code matches:
Phenacetin

Combiflu

Chlorphenamine

Coldflu

Calpol

Fervex

Panadol Extra

Panadol for children

Panadol

Solpadeine

Efferalgan

Milistan

Coldrex Maxgripp

Coldrex Hotrem

Coldrex

AntiGrippin

Unispaz

Pentalgin Plus

Rapidol

Maxicold

Duspatalin, Mebsin Retard, Moreaze SR, Trimpa.

Reviews about Trigan-D

According to reviews, the product helps to effectively relieve spasms and pain in the vast majority of cases.

paracetamol are also known . As a result, after consuming the resulting substance, side effects occur on the psyche and nervous system, called “highs.” You should know that this is an extremely harmful effect that can lead to irreparable consequences. On specialized forums, you often encounter questions like “how to remove paracetamol from Trigan to get the drug?” We strongly advise you not to engage in such experiments with medications and your body.

What to do if you have drug addiction

All forms and analogues of Trigan D are drugs that are dangerous due to their imaginary harmlessness. Psychological dependence on the drug develops, which cannot be completely eliminated by traditional drug courses of treatment designed for 12 or 28 days.

The Narconon social adaptation program is radically different from them. Drug addicts taking Trigan D do not receive drug treatment, which is especially important for psychological dependence. The program includes stages that eliminate the causes and consequences of addiction and return the patient to normal social life:

communication skills are restored;
a clear outlook on life is gained;
a person acquires the skill of understanding people, distinguishing friends from enemies;
a person realizes his obligations, stops looking for a return to the past, feels the desire to get Trigun D, buy it;
the skill of creative problem solving in life is formed.

After completing the last stage, the patient receives tools that will allow him to give up the drug forever. The technique helps overcome addiction and maintain the positive effect forever.

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