The role of magnesium preparations in the management of therapeutic patients

Over 80,000 clinical, biochemical, and cellular molecular studies published over the past 30 years indicate that adequate levels of magnesium in the body are a fundamental indicator of human health.

However, modern lifestyle, which usually includes high levels of stress, an unbalanced diet with the presence of large amounts of artificial foods, inevitably leads to magnesium deficiency.

In this article I will tell you how and why magnesium is needed, which dietary supplements with magnesium to choose and how to take it correctly.

Important facts:
1. The intracellular concentration of magnesium in the body decreases with age1.
2. Magnesium increases the effectiveness of glucose-lowering therapy in patients with type 2 diabetes mellitus2.
3. Magnesium is not produced by the body and can only be obtained from food or supplements3.
4. Magnesium reduces the risk of developing Alzheimer's disease and improves memory. This is due to the fact that this mineral reduces the risk of developing amyloid plaques in the hippocampus and prefrontal cortex, and enhances the work of synaptic nerve endings responsible for the transmission and storage of information (short-term and long-term memory).
5. The three leading factors contributing to the excretion of magnesium are: stress, alcohol, tobacco.

IMPORTANT!

Read also:  Nimika tab. dispers. 100 mg per blister. in pack No. 10x2 (nimesulide)

If you have excess calcium and not enough magnesium, this can lead to the development of tissue calcification. After all, it is magnesium that converts vitamin D into its active form! Therefore, please note: if you are recommended to take large doses of vitamin D, which helps calcium to be absorbed well, taking magnesium is a must!

Symptoms that may indicate low magnesium levels:

• headaches, dizziness;
• constant fatigue, apathy;
• sleep disorder;
• poor quality of nails and hair;
• anxiety, depression;
• indigestion (nausea, heartburn, constipation);
• cramps and spasms in the lower extremities.

In children, deficits may manifest themselves in:

• low concentration;
• increased excitability;
• decreased memory;
• increased irritability;
• hyperactivity.

Magnesium deficiency is dangerous due to the development of:

• urolithiasis and cholelithiasis;
• increased blood cholesterol;
• development of cardiovascular diseases;
• carbohydrate metabolism disorders;
• development of insomnia.

SportExpert Liquid magnesium, 8 doses of 50 ml, Evalar

463 ₽

Dietary supplement NOT A MEDICINE

Magnesium and sports

Some more important and interesting facts about magnesium:

1. In marathon runners, after a 42 km race, a significant decrease in the concentration of magnesium in the blood serum was recorded against the background of an increase in potassium and sodium levels5.
2. In middle- and long-distance runners, an ergometer test showed a significant increase in serum calcium and magnesium levels, however, against the background of an increase in cortisol and thyroid hormone levels, the level of magnesium in red blood cells significantly decreased6. However, magnesium supplementation improves blood glucose metabolism, reduces the inflammatory response, and reduces muscle soreness after exercise7.
3. When swimming, plasma magnesium levels decrease even in experienced swimmers. This is due to the participation of this mineral in thermoregulation, and we know that swimming is a sport that requires constant maintenance of body temperature in water8.

It is important to remember that hormone levels, particularly adrenaline and insulin, change significantly during exercise and require additional magnesium supplementation, since magnesium ions are necessary to maintain normal receptor sensitivity to these hormones.

Chronic magnesium deficiency contributes to impaired fat metabolism, changes in blood sugar levels9, and increased blood pressure during physical activity10.

Reduced levels of magnesium in the blood, associated with insufficient intake, against the background of physical exercise stimulate the development of inflammatory processes and contribute to the development of immunological disorders11.

How to take Mg correctly

Scientific research has proven that each of us needs this trace element. But few people know how to take magnesium, if it is vitamin supplements, how long to take them and whether they can be combined with other medications.

When taking magnesium supplements, it is important to maintain a balance of Mg, Ca, vitamins K2 and D.

• Ideally, the ratio of Mg to Ca should be 1/1. The fact is that calcium in large quantities reduces the absorption of magnesium. Therefore, if your diet contains a lot of calcium, then, accordingly, it is necessary to increase your Mg intake.
• Vitamin K2 performs a restorative function in diseases of the cardiovascular system and damage to bone tissue. By neutralizing calcium from the lining of blood vessels and moving the mineral into the bones, vitamin K2 prevents congestion and blood clots, while increasing bone strength.
• Vitamin K2 and D have a complex effect on the mucous membrane of the arteries and prevent the formation of calcium crystals. Together with magnesium, vitamin K2 helps lower blood pressure, which increases due to vascular dysfunction.

Vitamin complexes and medications

Among the pharmacy options for magnesium preparations, the most famous and widely used are Magne B6, Magne B6 Forte, Magnelis B6, Magnesia, Asparkam, Panangin, Complivit Magnesium.

1. Magne B 6 is taken 3-4 times a day, 1 ampoule. Its contents are dissolved in half a glass of water. After normalization of Mg concentration in the blood, it is recommended to stop using the drug.
2. Magne B 6 Forte is recommended to drink 3-4 times a day, 1 tablet during meals, with a glass of water. The course of treatment is 1 month.
3. Magnelis B 6 should be taken 6-8 tablets throughout the day. After normalization of Mg levels in the body, it is recommended to stop taking it.
4. Magnesia (magnesium sulfate) has several forms of release - injection solution, powder for suspension, balls. This drug should only be taken as prescribed by a doctor. It is he who determines in what form the medicine should be used and its dosage.
5. Asparkam also has two forms of release - tablets for oral administration and injections for intravenous administration. Only the attending physician can prescribe this drug, choose its form and the correct dosage.
6. Panangin is intended only for intravenous administration via a dropper. The dosage, 1 or 2 ampoules at a time, is prescribed by the doctor. The drug is administered together with glucose.
7. Complivit Magnesium is produced in the form of tablets, which are taken once a day with meals for a month.

Any drug and vitamin-mineral complex has a number of contraindications, so before you start taking this or that drug, you should consult with your doctor.

Magnesium Citrate, 60 Tablets, Solgar

Magnesium citrate (magnesium salt of citric acid) has been used in therapy for more than 50 years and is used to prevent the formation of kidney stones, prevent and treat hypomagnesemia.

Magnesium salt of citric acid has a high safety profile and is acceptable for use in case of kidney problems. Unlike inorganic salts, this form leads to better absorption of magnesium with reduced stomach acidity compared to magnesium lactate and other organic forms of magnesium.

Magnesium chelate, 60 tablets, Evalar

729 ₽

Dietary supplement NOT A MEDICINE

Why is it needed?

One of the main functions of magnesium is the creation of adenosite triphosphate, or ATP, a universal source of energy
for the entire body, the “energy station” of each cell.
In addition, it takes an active part in protein synthesis
and the absorption of certain nutrients.
For example, vitamin B6 (pyridoxine) can only be absorbed in the presence of magnesium. The second, no less important role of magnesium is the regulation of the balance of sodium and calcium
in cells.
This is especially important for the normal functioning of the nervous system and heart muscle. The correct balance of minerals prevents spasms from developing and allows the heart to pump blood without interruption. Thus, magnesium helps regulate heart rhythm and prevent the development of coronary heart disease and heart attacks. Magnesium plays an important role in normalizing blood pressure
.
Thus, a diet rich in fruits and vegetables containing a lot of magnesium significantly reduces the risk of developing hypertension. This mineral takes part in calcium metabolism in the body and helps in the restoration and growth of bone tissue. We can say that without the help of magnesium, the body cannot absorb calcium. Magnesium affects carbohydrate metabolism
by participating in the production of insulin, which controls blood glucose levels. In addition, it is involved in regulating blood clotting, protecting against the formation of blood clots.

Magnesium B6 solution, 100 ml, Evalar

Pay attention to the liquid form of Magnesium from the Evalar company, which can be given to both children from three years old and pregnant/lactating women, because it contains metal ions, a natural thickener, purified water and citric acid as a stabilizer. It has a high safety profile, and due to its liquid form it is effective. This form is also suitable for vegetarians.

Magnesium B6 solution, 100 ml, Evalar

389 ₽

Dietary supplement NOT A MEDICINE

What foods contain magnesium?

Eating foods containing magnesium can increase the amount of magnesium in the body. Eating a variety of whole grains, legumes (such as peas and beans), and dark green leafy vegetables every day will help you get the recommended daily allowance of magnesium. You can also get magnesium by drinking water. Water, including tap, mineral and bottled water, can contain up to 120 mg of magnesium, depending on the manufacturer of the water and its place of origin. The table below lists foods and the amount of magnesium in each.

*N/A - not applicable

**CH = Daily Value (DV). This column shows the percentage of the recommended daily intake. Foods that provide 20% of your DV per serving are foods high in magnesium.

to come back to the beginning

Panangin

In addition to magnesium, this drug also contains potassium, so Panangin is usually prescribed for heart problems, in particular for rhythm disturbances. This remedy is indicated for elderly people with arterial hypertension. The fact is that while taking blood pressure medications with a diuretic effect, potassium is “washed out” of the body. The medicine should be taken only on the recommendation of a doctor. The maximum daily dose of Panangin is three tablets three times a day, and the course of treatment is a month. In addition to tablets, Panangin is also available in the form of injections for treatment in a hospital. This magnesium and potassium supplement is well tolerated and is quite affordable. Contraindications include renal failure, elevated levels of magnesium and potassium in the blood, as well as severe atrioventricular block. Pregnant women, especially in the first trimester, need to take Panangin with caution to prevent excess potassium.

Panangin

Gedeon Richter, Hungary

As part of complex therapy for heart failure, acute myocardial infarction, cardiac arrhythmias (mainly ventricular arrhythmias, as well as arrhythmias caused by an overdose of cardiac glycosides);
- to improve the tolerability of cardiac glycosides; — replenishment of potassium and magnesium deficiency when their content in the diet is reduced (for tablets). from 115

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Magnesium Rich Foods

Photos from open sources

What does magnesium do in the body?

1. Magnesium is necessary to provide the cell with energy.
2. Without magnesium, B vitamins and vitamin C cannot be synthesized (that is, without magnesium, these vitamins do not enter the body).
3. Magnesium interacts with calcium, strengthening bones, magnesium is necessary for muscle tone, it eliminates cramps and joint pain.
4. Magnesium makes blood vessels strong, reduces blood pressure and regulates heart contractions (necessary for normal rhythm).
5. Magnesium reacts with insulin, helping it penetrate cells, thereby regulating glucose levels.
6. Magnesium helps skin heal after cuts and burns.

This is not a complete list of processes involving magnesium, but it is sufficient to understand how necessary the microelement is for our body.

Magnesium helps:

• in the prevention of headaches;
• cope with insomnia, stress and fatigue;
• relax the muscles;
• cope with depression faster;
• work of the musculoskeletal system;
• keep bones and teeth healthy. Read also How to strengthen the immune system: top 10 vitamins for schoolchildren The best vitamins for schoolchildren. Increases physical and mental endurance, strengthens the immune system, nervous system, bones and teeth.

Magnesium as a medicine

Magnesium

(lat.
magnesium
) - chemical element, atomic number 12, alkaline earth element, metal.
Designation - Mg
.
Magnesium plays a vital role in human physiology. Magnesium and its compounds are included in many medications used in the treatment of the gastrointestinal tract. Antacids should be placed in first place in terms of frequency of their use, and osmotic laxatives in second place. Content

• Basic functions and norms of magnesium consumption
• Magnesium deficiency in the body and means of compensating for it
• Magnesium compounds - antacids
• Magnesium compounds are laxatives
• Magnesium and cardiovascular disease
• Mineral waters with high magnesium content
• Possible effects of magnesium-containing products on the human body
• Publications for healthcare professionals addressing the role of magnesium in the treatment of gastrointestinal diseases
• Magnesium content in the human body
• Patient Materials
• Appendix 1. Magnesium compounds in the Anatomical Therapeutic Chemical Classification (ATC)
• Appendix 2. Magnesium content in some products

Basic functions and norms of magnesium consumption

According to Methodological Recommendations MP 2.3.1.2432-08 “Norms of physiological needs for energy and nutrients for various groups of the population of the Russian Federation”, approved by Rospotrebnadzor on December 18, 2008, magnesium is a cofactor of many enzymes, including energy metabolism, and is involved in protein synthesis , nucleic acids, has a stabilizing effect on membranes, and is necessary to maintain the homeostasis of calcium, potassium and sodium.
A lack of magnesium leads to hypomagnesemia, an increased risk of developing hypertension and heart disease. The average magnesium consumption in different countries is 210-350 mg/day, in the Russian Federation - 300 mg/day. Magnesium requirement levels are 200-500 mg/day. The upper acceptable level has not been established. The physiological need for magnesium for adults is 400 mg/day. The physiological need for children is from 55 to 400 mg/day. The 2015–2020 Dietary Guidelines for Americans (official publication of the US Department of Health) recommends the following daily intakes of magnesium:

• children 1-3 years old - 80 mg, 4-8 years old - 130 mg, 9-13 years old - 240 mg
• girls 14-18 years old - 360 mg, boys 14-18 years old - 410 mg
• females 19-30 years old - 310 mg, over 30 years old - 320 mg
• males 19-30 years old - 400 mg, over 30 years old - 420 mg

Magnesium deficiency in the body and means of compensating for it

Magnesium deficiency, accompanied by minor sleep disturbances, increased irritability, mild anxiety, increased fatigue, spasms of the calf muscles, can be compensated by taking medications, vitamin-mineral complexes, dietary supplements or mineral water with a high magnesium content.
Magnesium deficiency manifests itself in a variety of clinical symptoms and syndromes. Since the heterogeneity of the distribution of magnesium in the tissues of the body makes the determination of its content in serum or red blood cells less informative, magnesium deficiency can be suspected based on a combination of individual clinical signs of magnesium deficiency, especially if they affect different systems and are observed against the background of a significant provoking factor, such as alcohol abuse. A consequence of magnesium deficiency may be the development of atherosclerosis, arterial hypertension, tachycardia and various arrhythmias; with magnesium deficiency, the mortality rate in myocardial infarction increases; magnesium deficiency has been found in patients with mitral valve prolapse.

Most often, a rapidly developing lack of magnesium in the body leads to a state of increased nervous excitability of the cell. This is especially noticeable in muscle cells, in which depolarization is the main function. With magnesium deficiency, they experience impaired depolarization, which manifests itself in the redundancy of contraction processes in relation to relaxation processes. Clinically, these are muscle twitching and cramps, most often in the calf muscles, which is a common problem during pregnancy. Arrhythmia in pregnant women is also often associated with magnesium deficiency. For cardiomyocytes this is expressed in low efficiency of diastole, for smooth muscles - in spastic processes (Gromova O.A.).

Intramuscular administration of some magnesium preparations, so widespread in Russia, is not used in developed countries for ethical reasons due to severe pain at the injection site and a real threat of abscess formation. Parenteral magnesium therapy is indicated only in urgent situations of magnesium deficiency. The usual dose is 100 mg/hour intravenously or via auto-syringe for 4–6 hours per day. For eclampsia, slow intravenous administration of 25% magnesium sulfate in a dose of 10–20 ml is acceptable. With rapid administration of magnesium, hypermagnesemia is possible. Parenteral magnesium therapy, in case of urgent need, should be carried out only in hospital settings. The drugs of choice for long-term prevention and treatment of magnesium deficiency are oral dosage forms. At the same time, organic magnesium salts (magnesium citrate, magnesium pidolate, magnesium lactate and others) are not only much better absorbed, but also easier to tolerate by patients. They are less likely to cause side effects from the gastrointestinal tract and better compensate for magnesium deficiency (Gromova O.A.).

Magnesium deficiency in the body is not always accompanied by a low level of magnesium in the blood serum. A lack of magnesium in the blood is called hypomagnesemia.

Magnesium compounds - antacids

Many magnesium salts are used as antacids (see Appendix 1).
Antacids are divided into two large classes - absorbable (soluble in the blood) and non-absorbable (insoluble). Absorbed antacids are those that either themselves or the products of their reaction with gastric acid dissolve in the blood. Absorbable antacids are characterized by the rapid onset of the effect of taking the medication. Disadvantages of absorbed antacids: short duration of action, acid rebound (increased secretion of hydrochloric acid after the end of their action), the formation of carbon dioxide during their reaction with hydrochloric acid, which stretches the stomach and stimulates gastroesophageal reflux. Among magnesium salts there are absorbable antacids (magnesium carbonate and magnesium oxide) and non-absorbable ones (magnesium hydroxide, magnesium trisilicate and others). To date, due to their shortcomings, absorbable antacids have, for the most part, given way to non-absorbable ones. The only widely used absorbable antacid today is Rennie tablets with the active ingredient calcium carbonate + magnesium carbonate.

Today, monotherapy with antacids – metal salts – is practically not used. Modern antacids contain a balanced complex of active substances that compensate for each other's deficiencies. Most often, they combine magnesium salts, which have a laxative effect, and aluminum salts, which have a fixing effect. Examples of such drugs are “Almagel”, “Altacid”, “Alumag”, “Gastratcid”, “Maalox”, “Maalukol” and “Palmagel” (active ingredient “aluminum hydroxide + magnesium hydroxide”). Often simethicone (Almagel Neo, Antareit, Gestid, Relzer) is added to magnesium and aluminum compounds to prevent flatulence or benzocaine (Almagel A, Palmagel A) to relieve pain. There are also combinations of magnesium hydroxide and hydrotalcide (Gastal) and others.

Magnesium salts, which are part of non-absorbable antacids (magnesium hydroxide and others), are absorbed in the stomach and intestines only in minimal quantities. However, any significant increase in the level of magnesium in the blood serum occurs only in patients with severe renal failure (Ilchenko A.A., Selezneva E.Ya.).

Magnesium compounds are laxatives

Many magnesium salts (see Appendix 1) are osmotic laxatives. The therapeutic effect of osmotic laxatives is to attract water into the intestinal lumen along an osmotic gradient. This is accompanied by an increase in the volume of contents and easier movement, the consistency of stool becomes softer, and the frequency of bowel movements increases. The undesirable side of the action of saline osmotic laxatives, which include magnesium sulfate, magnesium phosphate, magnesium oxide, magnesium hydroxide, magnesium citrate, is that their action spreads throughout the intestines and carries the risk of electrolyte disorders, whereas the point of application of the “ideal laxative” "There must be a large intestine. In patients with cardiovascular and renal failure, salt osmotic laxatives can provoke volume and electrolyte overload (Shulpekova Yu.O.).

Magnesium and cardiovascular disease

Magnesium and magnesium salts have been used in the treatment of cardiac and vascular diseases since the last century.
The greatest effects from the use of magnesium preparations in complex therapy are associated with the treatment of combined arterial hypertension with hyperlipidemia, manifestations of myocardial ischemia; combined arterial hypertension with impaired glucose tolerance or type 2 diabetes mellitus; prevention and treatment of stress-induced cardiovascular complications. In cardiology, the anti-ischemic, antiarrhythmic, hypotensive, diuretic effects of magnesium are used, which are achieved in the absence of obvious signs of magnesium deficiency and, most likely, are a consequence of antagonism with calcium, but are far from being limited to this mechanism. Magnesium preparations are active both in urgent situations (intravenous administration) and with continuous oral administration in combination therapy for cardiovascular pathology. One of the magnesium preparations used in the treatment of cardiovascular diseases is magnesium orotate (see).

On the other hand, the inclusion of certain magnesium salts in the composition of cardiovascular drugs reduces the risk of gastroenterological adverse events such as drug ulcers and gastric erosions. Such a drug, for example, is the antiplatelet drug Cardiomagnyl, which contains, in addition to acetylsalicylic acid, magnesium hydroxide, which acts as an antacid.

Possible effects of magnesium-containing products on the human body

Antacids containing aluminum and magnesium are additionally capable of adsorbing pepsin, bile acids, and lysolecithin, which has an additional protective effect.
It is important that the adsorption of these components of duodenal contents may also have an additional therapeutic effect in relation to the suppression of pancreatic secretion in pancreatitis. Magnesium compounds have antipeptic activity (mainly due to inhibition of pepsin release), a stimulating effect on the production of gastric mucus, and the ability to enhance gastrointestinal motility; a protective effect on the gastric mucosa is expressed. Drugs containing magnesium should be taken for a long time (over several months) with caution, even in therapeutic doses. It has been shown that magnesium compounds can interfere with the absorption of folic acid in the intestine, the absorption of potassium (which must be especially taken into account if the patient suffers from arrhythmia or is taking cardiac glycosides) (Shulpekova Yu.O., Ivashkin V.T.). One of the features of the action of magnesium-containing antacids is an increase in intestinal motor function, which can lead to normalization of stool, but if taken in excess, it can lead to the development of diarrhea. An overdose of magnesium-containing antacids increases the magnesium content in the body of patients, which can cause bradycardia and/or renal failure (Vasiliev Yu.V.).

Accumulation of magnesium in the body leads to hypermagnesemia followed by bradycardia in children with renal failure (Belmer S.V.).

Absorbable magnesium-containing antacids are not recommended for use in pregnant women and in patients with renal failure due to the possible development of neurological and cardiovascular disorders (Fadeenko G.D.).

Mineral waters with high magnesium content

Many mineral waters contain magnesium in therapeutically significant amounts. Below, the table lists some of them.

Magnesium cations present in mineral waters, like calcium cations, reduce the permeability of cell membranes and, therefore, have an anti-inflammatory effect. They have a sedative, choleretic and laxative effect (especially in combination with sulfate anions) (Baranovsky A.Yu. et al.).

Publications for healthcare professionals addressing the role of magnesium in the treatment of gastrointestinal diseases

• Belmer S.V., Kovalenko A.A., Gasilina T.V. Antacid drugs in modern clinical practice // Doctor.ru. – 2004. – No. 4. – p. 19–22.
• Kolganova K.A. Modern aspects of the use of antacid drugs in the practice of a gastroenterologist // RMZh. Diseases of the digestive system. – 2008. – volume 10. – No. 2. – p. 80–82.
• Shulpekova Yu.O., Ivashkin V.T. Antacids and their place in the treatment of pancreatitis // Russian Medical Journal. Diseases of the Digestive Organs. – 2004. – T.6. – No. 2.
• Antropova O.N., Pyrikova N.V., Osipova I.V. Atrial fibrillation and gastroesophageal disease: mechanisms of relationship, approaches to treatment. Russian Journal of Cardiology. 2019;24(7):103–109..

On the website GastroScan.ru in the “Literature” section there is a subsection “Antacids”, containing articles devoted to the treatment of diseases of the gastrointestinal tract with antacids, including various magnesium compounds.

Magnesium content in the human body

67% of the total amount of magnesium in the human body is contained in bone tissue, 31% in cells, 1–2% in extracellular fluid. The daily requirement for magnesium is 300 mg for women, 350 mg for men, and approximately 150 mg more for pregnant women, nursing mothers, and young adolescents. The need for magnesium increases with heavy muscle load. Only 30–40% of this amount is absorbed, mainly in the duodenum and distal jejunum. Magnesium excretion is mainly carried out by the kidneys and averages 6–12 mEq/day. Magnesium reabsorption in the kidneys is extremely efficient: 25% of magnesium filtered in the glomeruli is reabsorbed in the proximal renal tubules, and another 50–60% in the thick segment of the ascending limb of the loop of Henle.

The content of magnesium Mg2+ in the blood is determined using a biochemical analysis.
Normal values ​​depend on the patient’s age and are within the limits indicated in the table on the right (Ingerleib M.G.). Deviations from the norm to a lesser extent are called hypomagnesemia, and to a greater extent - hypermaginemia. To determine the content of microelements and, in particular, magnesium in the body, hair is a convenient material. The normal value is 25–100 mcg of magnesium per gram of hair biosubstrate. At the same time, in patients with chronic gastroduodenitis and peptic ulcer of the stomach and duodenum, the level of magnesium in the biosubstrate increases to approximately 140 and 155 mcg/g, respectively, which is explained by the increased need for them in patients with chronic gastroduodenitis and peptic ulcer, and, as a consequence of their compensatory metabolic “ relocation" in the biosubstrates of the body (Sergeev V.N.).

Disorders of magnesium metabolism in the human body according to the International Classification of Diseases ICD-10 belong to “Class IV. Diseases of the endocrine system, nutritional disorders and metabolic disorders" and are presented in blocks:

• “E50-E64 Other types of malnutrition”, heading “E61.3 Magnesium deficiency”
• “E70-E90 Metabolic disorders”, heading “E83.4 Disorders of magnesium metabolism”, including hypermagnesemia and hypomagnesemia.

Patient Materials

The GastroScan.ru website contains materials for patients on various aspects of gastroenterology:

• “Advice from doctors” in the “Patients” section of the site
• “Popular gastroenterology” in the “Literature” section
• “Popular gastroenterology” in the “Video” section

Appendix 1. Magnesium compounds in the Anatomical Therapeutic Chemical Classification (ATC)

The importance of magnesium compounds for pharmacotherapy of the digestive tract is emphasized by a significant number of positions of the Anatomical Therapeutic Chemical Classification (ATC) - magnesium compounds belonging to the ATX section “A.”
Drugs affecting the digestive tract and metabolism.” Including: Subsection ATC "A02A Antacids" contains a separate group "A02AA Magnesium Preparations", which includes the following items: A02AA01 Magnesium carbonate A02AA02 Magnesium oxide A02AA03 Magnesium peroxide A02AA04 Magnesium hydroxide A02AA05 Magnesium silicate A02AA10 Combination of magnesium preparations Subsection ATC "A06 Laxatives" " includes the group "A06AD Osmotic laxatives", which, among others, contains the following entries: A06AD01 Magnesium carbonate A06AD02 Magnesium oxide A06AD03 Magnesium peroxide A06AD04 Magnesium sulfate A06AD19 Magnesium citrate

Subsection ATC "A12 Mineral Supplements" includes the group "A12CC Magnesium Preparations", consisting of the following items: A12CC01 Magnesium chloride A12CC02 Magnesium sulfate A12CC03 Magnesium gluconate A12CC04 Magnesium citrate A12CC05 Magnesium aspartate A12CC06 Magnesium lactate A12CC07 Magnesium levulinate A12CC08 Magnesium pidolate A12CC09 Magnesium orotate A12CC10 Magnesium oxide A12CC30 Combination of various magnesium salts

In addition to section “A”, magnesium preparations are also available in other sections of the ATC, in particular:

• in section "B. Drugs affecting hematopoiesis and blood”, subsection “B05 Plasma replacement and perfusion solutions”, magnesium salts are assigned the following codes:
• in the group “B05CB Saline solutions”:
• B05CB03 Magnesium citrate

• B05XA05 Magnesium sulfate
• B05XA10 Magnesium phosphate
• B05XA11 Magnesium chloride

Appendix 2. Magnesium content in some products

The table below shows the magnesium content in some foods (Skalny A.V.):
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Among vegetable oils, camelina oil has a high magnesium content. Back to section

The most important

Magnesium is necessary for the functioning of all body systems: it helps cells receive energy, regulates the functioning of the heart and nervous system, and participates in the formation of bone tissue.
A lack of magnesium is caused by an unbalanced diet, addiction to diuretics and laxatives, as well as an addiction to alcohol and coffee. Tags:

• Alcohol
• Metabolism
• Avitaminosis
• Caffeine
• Calcium
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Magnerot

Magnerot is a magnesium orotate that is usually prescribed to patients with cardiac problems, although the drug can be taken for other symptoms of magnesium deficiency. “Magnerot” is indicated for people who have had a heart attack, with coronary heart disease, heart failure, arrhythmias, muscle pain, atherosclerosis, and lipid metabolism disorders. Magnerot is not cheap and has the same contraindications as previous drugs. In addition, Magnerot should not be taken if you have cirrhosis of the liver or urolithiasis. You need to take the drug 6 tablets per day (for a week). Then - one tablet three times a day.

Magnerot

Woerwag Pharma GmbH & Co. KG, Germany

Magnerot is a magnesium preparation containing magnesium orotate dihydrate.
Magnesium is a macroelement that takes part in energy, protein, lipid and carbohydrate metabolism, as well as the metabolism of nucleic acids. Magnesium inhibits neuromuscular transmission by regulating neuromuscular excitation. Magnesium is a natural calcium antagonist, takes part in the regulation of myocardial contractile function, and is necessary to maintain normal cardiomyocyte function. from 218

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Magne Express

This drug contains magnesium citrate and vitamin B6. This combination is very effective - these two substances enhance each other’s effects. "Magne Express" is prescribed for a slight lack of magnesium, as well as for the prevention of its deficiency. You can buy “Magnesium Express” in the form of a sachet (bags of granules for resorption). The drug is taken after meals (one sachet twice a day), there is no need to wash it down with water. The course of treatment is one month. The granules taste sweet and sour, with the aroma of tropical fruits. This magnesium citrate has high bioavailability, but is recommended to be taken as a dietary supplement. If there is a serious lack of magnesium, it is better to choose another drug (magnesium lactate), which will be prescribed by your doctor. Magne Express should not be taken during pregnancy, breastfeeding, kidney failure or while taking medications for Parkinson's disease. One of the disadvantages of this magnesium supplement is its high cost.

Magne Express

Pontroy Vitarmonil Industry, France

Magne Express is a dietary supplement that helps normalize the functioning of the nervous system and increases stress resistance.
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What prevents it from being absorbed?

Magnesium deficiency occurs in areas where people drink water that is too soft and lacks minerals. Magnesium is very well excreted from the body through fluids, and its deficiency easily occurs when using diuretics or laxatives
, including those included in weight loss products.
Magnesium is lost in large quantities when drinking alcohol
. Moreover, its loss does not depend on the strength of alcohol - any alcohol-containing drink is a strong diuretic. By the way, excessive coffee consumption also leads to magnesium deficiency. This drink also promotes the active removal of fluid from the body. A lack of magnesium is observed both in people who eat mainly refined foods and in those whose diet consists mainly of meat products.

Which magnesium supplement should you choose?

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Content

• Why does the body need magnesium?
• What does magnesium do in the body?
• Symptoms of magnesium deficiency
• Top 5 magnesium preparations
• Magne Express
• Magne B6
• Magnerot
• Complivit Magnesium
• Panangin
• What foods are high in magnesium?

Magnesium is found in all tissues of the human body, because this essential element ensures the proper functioning of cells. Today we will tell you in what processes magnesium is involved, what are the symptoms of its deficiency and how to choose a good magnesium supplement.