Compound
The active substance is ketotifen in the form of ketotifen fumarate .
Ketotifen tablets contain 1 mg of active ingredient. Additional substances: lactose monohydrate, starch, magnesium stearate.
The syrup contains 1 mg/5 ml of active ingredient.
Eye drops contain 0.25 mg/ml of active substance. Additional substances: sodium hydroxide, benzalkonium chloride, Trilon B, dextran , sodium chloride, purified water, citric acid.
Indications for use
Eye drops are widely used by ophthalmologists to treat the following allergic reactions:
- acute or subacute allergic conjunctivitis;
- the occurrence of keratoconjunctivitis;
- development of chronic conjunctivitis, expressed in an allergic form;
- seasonal allergic conjunctivitis.
The drug is used in courses for the treatment and prevention of the listed pathologies.
Pharmacodynamics and pharmacokinetics
The drug acts as follows: it inhibits the release of histamine, as well as other mediators from mast cells, it also blocks histamine H1 receptors , while inhibiting the PDE enzyme. of cAMP increases in mast cells . Ketotifen suppresses the effects of platelet-activating factor. If the drug is used independently, then attacks of bronchial asthma are not stopped. At the same time, the drug prevents their occurrence and significantly reduces the intensity and duration of these attacks. In some cases they stop completely. In blood plasma, the maximum concentration of the drug is observed after 2–4 hours. Metabolization of most of the drug dose occurs in the liver.
Pharmacological properties of the drug Ketotifen
Antiallergic and antiasthmatic agent. Exhibits antiallergic activity, suppressing the action of endogenous inflammatory mediators; does not have a bronchodilator effect. Ketotifen suppresses the release of allergy mediators (histamine, leukotrienes), inhibits the sensitization of eosinophilic granulocytes by cytokines, leading to suppression of the migration of eosinophilic granulocytes to areas of inflammation; suppresses the development of bronchial hyperreactivity, caused both by activation of platelets when exposed to platelet activating factor, and stimulation by sympathomimetics or allergens. In addition, ketotifen inhibits the enzyme phosphodiesterase, resulting in an increase in the level of cAMP in tissues. These properties of ketotifen determine its anti-asthmatic effect. Ketotifen also has a pronounced antiallergic effect, is able to non-competitively block H1 receptors and therefore can be used instead of their classical antagonists. After oral administration, ketotifen is almost completely absorbed, its bioavailability is about 50% due to metabolism during the first pass through the liver. The maximum concentration in blood plasma is achieved within 2–4 hours. Binding to blood plasma proteins is 75%. The elimination of ketotifen from the body is biphasic with a half-life of 3–5 hours and 21 hours. After instillation into the conjunctival sac, the antihistamine effect begins quickly and lasts 8–12 hours. Ketotifen reduces the severity of symptoms of allergic conjunctivitis (itching, hyperemia, etc.).
Side effects
During treatment with this drug, some side effects may develop. Quite often a state of drowsiness, dry mouth, increased drowsiness, and dizziness appears. There may be problems with the gastrointestinal tract - constipation , nausea, vomiting. These phenomena disappear spontaneously during treatment. Also, due to increased appetite, weight may increase. Symptoms of irritability and agitation and hypersensitivity occur less frequently. Children may experience seizures. hepatitis , cystitis , jaundice , and dark colored urine may occur Overdose may cause drowsiness, hypotension , dizziness, vomiting and nausea, and convulsions in children. In this situation, urgent gastric lavage and taking symptomatic medications are necessary.
Overdose of the drug Ketotifen, symptoms and treatment
Manifested by drowsiness, confusion, disorientation, tachycardia and arterial hypotension, increased excitability, convulsions, especially in children, coma. In case of overdose, gastric lavage is recommended; if necessary, symptomatic treatment and monitoring of the state of the cardiovascular system are carried out; for agitation or convulsions, short-acting barbiturates and benzodiazepines are prescribed.
List of pharmacies where you can buy Ketotifen:
- Moscow
- Saint Petersburg
Instructions for use of Ketotifen (Method and dosage)
Ketotifen tablets, instructions for use
Consume during meals, with a small amount of water. One tablet contains 1 mg of the drug. Adults take one tablet twice a day. Those patients who experience severe sedation should gradually increase the dose of the drug. This is done over seven days, you need to start with 0.5 mg. This dose is taken before bedtime, and the amount of the drug is gradually increased to a therapeutic dose. Children over three years old take 1 tablet twice a day - morning and evening. The drug is taken in the same way during meals.
Ketotifen Sopharma is used similarly.
Ketotifen syrup, instructions for use
Children from one to three years old can take Ketotifen exclusively in the form of syrup, which is prescribed at a dose of 0.25 ml per kg of the child’s weight twice a day. Children over 3 years old should take 5 ml of syrup twice a day with food.
Instructions for eye drops
Starting from 3 years, you can instill one drop twice a day into the conjunctival sac.
Treatment with Ketotifen takes a long period. In this case, a noticeable effect after taking it will be achieved after 2-3 weeks of therapy. The general course of treatment can be two to three months. Those patients who did not experience any visible effect after several weeks of taking the medication should take this medication for a particularly long period. Treatment with this drug is stopped gradually over several weeks. This is done to avoid recurrence of asthmatic symptoms .
Existing contraindications
Ketotifen eye drops should not be used in the following cases:
- the patient has individual hypersensitivity to any ingredient of the drug;
- women while bearing and feeding a child, since the components of the drug can penetrate the body of the fetus and baby;
- The patient's age is under 12 years.
It is recommended to use eye drops with caution if the patient has a history of liver and kidney failure, seizures and epilepsy.
special instructions
The drug is not used to relieve asthmatic attacks . When starting therapy with this drug, treatment with other anti-asthma drugs should not be abruptly stopped. This is especially true for systemic GCS . People who are dependent on steroids may develop adrenal insufficiency.
This drug has the property of lowering the seizure threshold, therefore, it is carefully prescribed to those patients who exhibit seizures. During pregnancy, this drug is prescribed only when there are direct indications and the benefits of taking it outweigh the risk to the woman and fetus. When taking the drug, you must stop breastfeeding. Due to the possible manifestation of drowsiness, ketotifen is recommended to be used very carefully by drivers and people working with potentially dangerous units.
According to the Sportsweeks website, the drug increases the sensitivity of beta-2 adrenergic receptors, as a result of which it is often used in bodybuilding and for weight loss. We advise you to consult your doctor about the possibility of using this medication.
Ketotifen's analogs
Level 4 ATC code matches:
Polynadim
Vizin Alergy
Zaditen
Cromohexal
Lecrolin
Opatanol
An analogue can be called the medicine Zaditen .
Ketotifen price
The price of Ketotifen in 1 mg tablets is 50 rubles per pack of 30 pieces.
The price of Ketotifen eye drops is 170 rubles.
The cost of syrup is 70 rubles.
You can buy the drug in Ukraine at the following prices:
- tablets - 10 UAH.
- syrup - 20 UAH.
- eye drops – 15 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Zaditen (Ketotifen) tablets 1 mg No. 30
RUB 2,150 order
ZdravCity
- Ketotifen tablets 1 mg 30 pcs. OzonOzon LLC
72 RUR order
- Ketotifen Sopharma tablets 1 mg 30 pcs. Sopharma AD
84 rub. order
- Ketotifen sopharma syrup 1mg/5ml 100mlSopharma AD
128 rub. order
- Ketotifen tablets 1 mg 30 pcs. JSC Irbitsky HFZ
67 RUR order
Pharmacy Dialogue
- Ketotifen tablets 1 mg No. 30 Irbitsky HFZ
62 RUR order
- Ketotifen tablets 1 mg No. 30Sopharma
72 RUR order
- Ketotifen syrup 100mlSopharma
111 rub. order
- Ketotifen tablets 1 mg No. 30 Shanghai Hengshan Pharmaceutical
79 RUR order
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Pharmacy24
- Ketotifen 100 ml syrup PAT NEC "Borshchagivsky chemical-pharmaceutical plant", Kiev, Ukraine
29 UAH. order - Ketotifen 0.001 g No. 10 tablets AT "Lekhim-Kharkiv", Ukraine
5 UAH order
- Ketotifen 1 mg No. 30 tablets AT "Lekhim-Kharkiv", Ukraine
12 UAH order
- Ketotifen Sopharma 1mg N30 tablets PAT "Vitamin" Ukraine
29 UAH order
- Ketotifen 50 ml syrup PAT NEC "Borshchagivsky chemical-pharmaceutical plant", Kiev, Ukraine
22 UAH order
PaniPharmacy
- KETOTIFEN tablets Ketotifen Sopharma tablets 1 mg No. 30 Bulgaria, Sopharma
32 UAH order
- KETOTIFEN tablets Ketotifen tablets. 1mg No. 30 Ukraine, OZ GNTsLS LLC
13 UAH order
- KETOTIFEN tablets Ketotifen tablets. 1mg No. 10 Ukraine, Lekhim-Kharkov CJSC
6 UAH order
- KETOTIFEN liquid Ketotifen h/c 0.025% 5ml Ukraine, OZ GNTsLS LLC
34 UAH order
- KETOTIFEN tablets Ketotifen tablets. 1mg No. 30 Ukraine, Lekhim-Kharkov CJSC
13 UAH order
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Drug interactions
When using Ketotifen eye drops simultaneously with other antihistamines, potentiation of the therapeutic effects is possible. If the drug is prescribed during therapy with oral antidiabetic medications, thrombocytopenia may occur.
If an acute allergic reaction develops, it is permissible to prescribe eye drops simultaneously with corticosteroids. However, in such situations, the attending physician should warn about the need for regular use of the drug.
